Synthesis of DNA/RNA and Their Analogs via Phosphoramidite and H-Phosphonate Chemistries
The chemical synthesis of DNA and RNA is universally carried out using nucleoside phosphoramidites or H-phosphonates as synthons. This review focuses on the phosphorus chemistry behind these synthons and how it has been developed to generate procedures whereby yields per condensation approach 100% w...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2013-11-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/18/11/14268 |
| _version_ | 1811254697259958272 |
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| author | Subhadeep Roy Marvin Caruthers |
| author_facet | Subhadeep Roy Marvin Caruthers |
| author_sort | Subhadeep Roy |
| collection | DOAJ |
| description | The chemical synthesis of DNA and RNA is universally carried out using nucleoside phosphoramidites or H-phosphonates as synthons. This review focuses on the phosphorus chemistry behind these synthons and how it has been developed to generate procedures whereby yields per condensation approach 100% with very few side products. Additionally the synthesis and properties of certain DNA and RNA analogs that are modified at phosphorus will also be discussed. These analogs include boranephosphonates, metallophosphonates, and alkylboranephosphines. |
| first_indexed | 2024-04-12T17:10:31Z |
| format | Article |
| id | doaj.art-cc53788fce7c468a9898d89157eba64e |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-12T17:10:31Z |
| publishDate | 2013-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-cc53788fce7c468a9898d89157eba64e2022-12-22T03:23:48ZengMDPI AGMolecules1420-30492013-11-011811142681428410.3390/molecules181114268molecules181114268Synthesis of DNA/RNA and Their Analogs via Phosphoramidite and H-Phosphonate ChemistriesSubhadeep Roy0Marvin Caruthers1Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USADepartment of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USAThe chemical synthesis of DNA and RNA is universally carried out using nucleoside phosphoramidites or H-phosphonates as synthons. This review focuses on the phosphorus chemistry behind these synthons and how it has been developed to generate procedures whereby yields per condensation approach 100% with very few side products. Additionally the synthesis and properties of certain DNA and RNA analogs that are modified at phosphorus will also be discussed. These analogs include boranephosphonates, metallophosphonates, and alkylboranephosphines.http://www.mdpi.com/1420-3049/18/11/14268DNARNAphosphoramiditesH-phosphonatesboranephosphonatesmetallophosphonatesboranealkylphosphines |
| spellingShingle | Subhadeep Roy Marvin Caruthers Synthesis of DNA/RNA and Their Analogs via Phosphoramidite and H-Phosphonate Chemistries Molecules DNA RNA phosphoramidites H-phosphonates boranephosphonates metallophosphonates boranealkylphosphines |
| title | Synthesis of DNA/RNA and Their Analogs via Phosphoramidite and H-Phosphonate Chemistries |
| title_full | Synthesis of DNA/RNA and Their Analogs via Phosphoramidite and H-Phosphonate Chemistries |
| title_fullStr | Synthesis of DNA/RNA and Their Analogs via Phosphoramidite and H-Phosphonate Chemistries |
| title_full_unstemmed | Synthesis of DNA/RNA and Their Analogs via Phosphoramidite and H-Phosphonate Chemistries |
| title_short | Synthesis of DNA/RNA and Their Analogs via Phosphoramidite and H-Phosphonate Chemistries |
| title_sort | synthesis of dna rna and their analogs via phosphoramidite and h phosphonate chemistries |
| topic | DNA RNA phosphoramidites H-phosphonates boranephosphonates metallophosphonates boranealkylphosphines |
| url | http://www.mdpi.com/1420-3049/18/11/14268 |
| work_keys_str_mv | AT subhadeeproy synthesisofdnarnaandtheiranalogsviaphosphoramiditeandhphosphonatechemistries AT marvincaruthers synthesisofdnarnaandtheiranalogsviaphosphoramiditeandhphosphonatechemistries |