Multiorgan eosinophilic infiltration after initiation of clozapine therapy: a case report
Abstract Background The eosinophilic response to clozapine is well described in the literature, causing a variety of responses, from serositis to colitis. However, there are not case reports describing a clozapine-induced marked eosinophilia resulting in multiorgan dysfunction. Case presentation In...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2017-07-01
|
| Series: | BMC Research Notes |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13104-017-2662-1 |
| _version_ | 1819068904738127872 |
|---|---|
| author | Dorota Marchel Anita L. Hart Patricia Keefer Jennifer Vredeveld |
| author_facet | Dorota Marchel Anita L. Hart Patricia Keefer Jennifer Vredeveld |
| author_sort | Dorota Marchel |
| collection | DOAJ |
| description | Abstract Background The eosinophilic response to clozapine is well described in the literature, causing a variety of responses, from serositis to colitis. However, there are not case reports describing a clozapine-induced marked eosinophilia resulting in multiorgan dysfunction. Case presentation In this case report, we describe a 24 year old Caucasian male who presented with severe systemic eosinophilia resulting in eosinophilic GI tract infiltration, myocarditis, pericardial and pleural effusions with dramatic improvement following drug withdrawal. Conclusions Clozapine associated eosinophilia should be suspected in the setting of eosinophilic infiltration of multiple organs. |
| first_indexed | 2024-12-21T16:41:34Z |
| format | Article |
| id | doaj.art-cc53862d7d51485888bc65a72534aefa |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-12-21T16:41:34Z |
| publishDate | 2017-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-cc53862d7d51485888bc65a72534aefa2022-12-21T18:57:05ZengBMCBMC Research Notes1756-05002017-07-011011310.1186/s13104-017-2662-1Multiorgan eosinophilic infiltration after initiation of clozapine therapy: a case reportDorota Marchel0Anita L. Hart1Patricia Keefer2Jennifer Vredeveld3Pediatric Primary Care Clinic, Rutledge TowerUniversity of Michigan Health SystemUniversity of Michigan Health SystemUniversity of Michigan Health SystemAbstract Background The eosinophilic response to clozapine is well described in the literature, causing a variety of responses, from serositis to colitis. However, there are not case reports describing a clozapine-induced marked eosinophilia resulting in multiorgan dysfunction. Case presentation In this case report, we describe a 24 year old Caucasian male who presented with severe systemic eosinophilia resulting in eosinophilic GI tract infiltration, myocarditis, pericardial and pleural effusions with dramatic improvement following drug withdrawal. Conclusions Clozapine associated eosinophilia should be suspected in the setting of eosinophilic infiltration of multiple organs.http://link.springer.com/article/10.1186/s13104-017-2662-1Case reportClozapineEosinophiliaEosinophilic infiltrationMultiorgan dysfunction |
| spellingShingle | Dorota Marchel Anita L. Hart Patricia Keefer Jennifer Vredeveld Multiorgan eosinophilic infiltration after initiation of clozapine therapy: a case report BMC Research Notes Case report Clozapine Eosinophilia Eosinophilic infiltration Multiorgan dysfunction |
| title | Multiorgan eosinophilic infiltration after initiation of clozapine therapy: a case report |
| title_full | Multiorgan eosinophilic infiltration after initiation of clozapine therapy: a case report |
| title_fullStr | Multiorgan eosinophilic infiltration after initiation of clozapine therapy: a case report |
| title_full_unstemmed | Multiorgan eosinophilic infiltration after initiation of clozapine therapy: a case report |
| title_short | Multiorgan eosinophilic infiltration after initiation of clozapine therapy: a case report |
| title_sort | multiorgan eosinophilic infiltration after initiation of clozapine therapy a case report |
| topic | Case report Clozapine Eosinophilia Eosinophilic infiltration Multiorgan dysfunction |
| url | http://link.springer.com/article/10.1186/s13104-017-2662-1 |
| work_keys_str_mv | AT dorotamarchel multiorganeosinophilicinfiltrationafterinitiationofclozapinetherapyacasereport AT anitalhart multiorganeosinophilicinfiltrationafterinitiationofclozapinetherapyacasereport AT patriciakeefer multiorganeosinophilicinfiltrationafterinitiationofclozapinetherapyacasereport AT jennifervredeveld multiorganeosinophilicinfiltrationafterinitiationofclozapinetherapyacasereport |