Markedly reduced ventricular arrhythmia during the peripartum period in a pregnant woman with Andersen-Tawil syndrome
Andersen-Tawil syndrome (ATS), also known as long QT syndrome type 7, is a rare autosomal dominant disease caused by a KCNJ2 mutation. The characteristic triad of ATS is periodic paralysis, dysmorphic features, and ventricular arrhythmia. We describe a case of a woman with Andersen-Tawil syndrome an...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-12-01
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| Series: | Journal of Arrhythmia |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1880427612001342 |
| _version_ | 1828327487735595008 |
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| author | Chizuko A. Kamiya Wataru Shimizu Yoshinari Kabayashi Takekazu Miyoshi Chinami Horiuchi Takashi Umekawa Kaoru Yamanaka Reiko Neki Shinji Katsuragi Jun Yoshimatsu Tomoaki Ikeda |
| author_facet | Chizuko A. Kamiya Wataru Shimizu Yoshinari Kabayashi Takekazu Miyoshi Chinami Horiuchi Takashi Umekawa Kaoru Yamanaka Reiko Neki Shinji Katsuragi Jun Yoshimatsu Tomoaki Ikeda |
| author_sort | Chizuko A. Kamiya |
| collection | DOAJ |
| description | Andersen-Tawil syndrome (ATS), also known as long QT syndrome type 7, is a rare autosomal dominant disease caused by a KCNJ2 mutation. The characteristic triad of ATS is periodic paralysis, dysmorphic features, and ventricular arrhythmia. We describe a case of a woman with Andersen-Tawil syndrome and a history of syncope whose pregnancy was complicated with frequent premature ventricular contractions (PVCs) and nonsustained ventricular tachycardia (NSVT). Her PVCs and NSVT were significantly decreased during the peripartum period, especially during labor. We treated her with beta-blockers throughout her pregnancy, and she experienced no complications. Although the mechanism underlying the decreased PVCs and NSVT in pregnancy has not been elucidated, women with ATS may have less arrhythmic event risk during pregnancy. |
| first_indexed | 2024-04-13T19:55:51Z |
| format | Article |
| id | doaj.art-cc539d42ccd745c680e388d604c5edab |
| institution | Directory Open Access Journal |
| issn | 1880-4276 |
| language | English |
| last_indexed | 2024-04-13T19:55:51Z |
| publishDate | 2012-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Arrhythmia |
| spelling | doaj.art-cc539d42ccd745c680e388d604c5edab2022-12-22T02:32:21ZengWileyJournal of Arrhythmia1880-42762012-12-0128636036310.1016/j.joa.2012.08.002Markedly reduced ventricular arrhythmia during the peripartum period in a pregnant woman with Andersen-Tawil syndromeChizuko A. Kamiya0Wataru Shimizu1Yoshinari Kabayashi2Takekazu Miyoshi3Chinami Horiuchi4Takashi Umekawa5Kaoru Yamanaka6Reiko Neki7Shinji Katsuragi8Jun Yoshimatsu9Tomoaki Ikeda10Departments of Perinatology and Gynecology, National Cerebral and Cardiovascular Center, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, JapanDepartment of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, JapanDepartments of Perinatology and Gynecology, National Cerebral and Cardiovascular Center, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, JapanDepartments of Perinatology and Gynecology, National Cerebral and Cardiovascular Center, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, JapanDepartments of Perinatology and Gynecology, National Cerebral and Cardiovascular Center, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, JapanDepartments of Perinatology and Gynecology, National Cerebral and Cardiovascular Center, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, JapanDepartments of Perinatology and Gynecology, National Cerebral and Cardiovascular Center, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, JapanDepartments of Perinatology and Gynecology, National Cerebral and Cardiovascular Center, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, JapanDepartments of Perinatology and Gynecology, National Cerebral and Cardiovascular Center, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, JapanDepartments of Perinatology and Gynecology, National Cerebral and Cardiovascular Center, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, JapanDepartments of Perinatology and Gynecology, National Cerebral and Cardiovascular Center, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, JapanAndersen-Tawil syndrome (ATS), also known as long QT syndrome type 7, is a rare autosomal dominant disease caused by a KCNJ2 mutation. The characteristic triad of ATS is periodic paralysis, dysmorphic features, and ventricular arrhythmia. We describe a case of a woman with Andersen-Tawil syndrome and a history of syncope whose pregnancy was complicated with frequent premature ventricular contractions (PVCs) and nonsustained ventricular tachycardia (NSVT). Her PVCs and NSVT were significantly decreased during the peripartum period, especially during labor. We treated her with beta-blockers throughout her pregnancy, and she experienced no complications. Although the mechanism underlying the decreased PVCs and NSVT in pregnancy has not been elucidated, women with ATS may have less arrhythmic event risk during pregnancy.http://www.sciencedirect.com/science/article/pii/S1880427612001342 |
| spellingShingle | Chizuko A. Kamiya Wataru Shimizu Yoshinari Kabayashi Takekazu Miyoshi Chinami Horiuchi Takashi Umekawa Kaoru Yamanaka Reiko Neki Shinji Katsuragi Jun Yoshimatsu Tomoaki Ikeda Markedly reduced ventricular arrhythmia during the peripartum period in a pregnant woman with Andersen-Tawil syndrome Journal of Arrhythmia |
| title | Markedly reduced ventricular arrhythmia during the peripartum period in a pregnant woman with Andersen-Tawil syndrome |
| title_full | Markedly reduced ventricular arrhythmia during the peripartum period in a pregnant woman with Andersen-Tawil syndrome |
| title_fullStr | Markedly reduced ventricular arrhythmia during the peripartum period in a pregnant woman with Andersen-Tawil syndrome |
| title_full_unstemmed | Markedly reduced ventricular arrhythmia during the peripartum period in a pregnant woman with Andersen-Tawil syndrome |
| title_short | Markedly reduced ventricular arrhythmia during the peripartum period in a pregnant woman with Andersen-Tawil syndrome |
| title_sort | markedly reduced ventricular arrhythmia during the peripartum period in a pregnant woman with andersen tawil syndrome |
| url | http://www.sciencedirect.com/science/article/pii/S1880427612001342 |
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