The role of innovative modeling and imaging techniques in improving outcomes in patients with LVAD
Heart failure remains a significant cause of mortality in the United States and around the world. While organ transplantation is acknowledged as the gold standard treatment for end stage heart failure, supply is limited, and many patients are treated with left ventricular assist devices (LVADs). LVA...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1248300/full |
| _version_ | 1797737539368386560 |
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| author | Shannon I. Wilson Katelyn E. Ingram Albert Oh Michael R. Moreno Mahwash Kassi |
| author_facet | Shannon I. Wilson Katelyn E. Ingram Albert Oh Michael R. Moreno Mahwash Kassi |
| author_sort | Shannon I. Wilson |
| collection | DOAJ |
| description | Heart failure remains a significant cause of mortality in the United States and around the world. While organ transplantation is acknowledged as the gold standard treatment for end stage heart failure, supply is limited, and many patients are treated with left ventricular assist devices (LVADs). LVADs extend and improve patients' lives, but they are not without their own complications, particularly the hemocompatibility related adverse events (HRAE) including stroke, bleeding and pump thrombosis. Mainstream imaging techniques currently in use to assess appropriate device function and troubleshoot complications, such as echocardiography and cardiac computed tomography, provide some insight but do not provide a holistic understanding of pump induced flow alterations that leads to HRAEs. In contrast, there are technologies restricted to the benchtop—such as computational fluid dynamics and mock circulatory loops paired with methods like particle image velocimetry—that can assess flow metrics but have not been optimized for clinical care. In this review, we outline the potential role and current limitations of converging available technologies to produce novel imaging techniques, and the potential utility in evaluating hemodynamic flow to determine whether LVAD patients may be at higher risk of HRAEs. This addition to diagnostic and monitoring capabilities could improve prevention and treatment of LVAD-induced complications in heart failure patients. |
| first_indexed | 2024-03-12T13:29:50Z |
| format | Article |
| id | doaj.art-cc5554ac8b304677a1083b50be8d6f5e |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-03-12T13:29:50Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-cc5554ac8b304677a1083b50be8d6f5e2023-08-24T21:13:14ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-08-011010.3389/fcvm.2023.12483001248300The role of innovative modeling and imaging techniques in improving outcomes in patients with LVADShannon I. Wilson0Katelyn E. Ingram1Albert Oh2Michael R. Moreno3Mahwash Kassi4Department of Biomedical Engineering, Texas A&M University, College Station, TX, United StatesDeBakey Heart and Vascular- Heart Center Research, Houston Methodist Research Institute, Houston, TX, United StatesSchool of Engineering Medicine, Texas A&M University, Houston, TX, United StatesJ. Mike Walker ‘66 Department of Mechanical Engineering, Texas A&M University, College Station, TX, United StatesCardiology, DeBakey Heart and Vascular, Houston Methodist Hospital, Houston, TX, United StatesHeart failure remains a significant cause of mortality in the United States and around the world. While organ transplantation is acknowledged as the gold standard treatment for end stage heart failure, supply is limited, and many patients are treated with left ventricular assist devices (LVADs). LVADs extend and improve patients' lives, but they are not without their own complications, particularly the hemocompatibility related adverse events (HRAE) including stroke, bleeding and pump thrombosis. Mainstream imaging techniques currently in use to assess appropriate device function and troubleshoot complications, such as echocardiography and cardiac computed tomography, provide some insight but do not provide a holistic understanding of pump induced flow alterations that leads to HRAEs. In contrast, there are technologies restricted to the benchtop—such as computational fluid dynamics and mock circulatory loops paired with methods like particle image velocimetry—that can assess flow metrics but have not been optimized for clinical care. In this review, we outline the potential role and current limitations of converging available technologies to produce novel imaging techniques, and the potential utility in evaluating hemodynamic flow to determine whether LVAD patients may be at higher risk of HRAEs. This addition to diagnostic and monitoring capabilities could improve prevention and treatment of LVAD-induced complications in heart failure patients.https://www.frontiersin.org/articles/10.3389/fcvm.2023.1248300/fullLVADimagingHRAEshemodynamicsoutcomes |
| spellingShingle | Shannon I. Wilson Katelyn E. Ingram Albert Oh Michael R. Moreno Mahwash Kassi The role of innovative modeling and imaging techniques in improving outcomes in patients with LVAD Frontiers in Cardiovascular Medicine LVAD imaging HRAEs hemodynamics outcomes |
| title | The role of innovative modeling and imaging techniques in improving outcomes in patients with LVAD |
| title_full | The role of innovative modeling and imaging techniques in improving outcomes in patients with LVAD |
| title_fullStr | The role of innovative modeling and imaging techniques in improving outcomes in patients with LVAD |
| title_full_unstemmed | The role of innovative modeling and imaging techniques in improving outcomes in patients with LVAD |
| title_short | The role of innovative modeling and imaging techniques in improving outcomes in patients with LVAD |
| title_sort | role of innovative modeling and imaging techniques in improving outcomes in patients with lvad |
| topic | LVAD imaging HRAEs hemodynamics outcomes |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1248300/full |
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