Biomarkers in Advanced Colorectal Cancer: Challenges in Translating Clinical Research into Practice
The growing number of therapeutic agents and known molecular targets in oncology makes the study and clinical use of biomarkers imperative for improving response and survival, reducing toxicity and ensuring economic sustainability. Colorectal cancer, among others, is at the forefront of development...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2011-04-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-6694/3/2/1844/ |
| _version_ | 1797764480249102336 |
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| author | Hendrik-Tobias Arkenau Charlotte Lemech |
| author_facet | Hendrik-Tobias Arkenau Charlotte Lemech |
| author_sort | Hendrik-Tobias Arkenau |
| collection | DOAJ |
| description | The growing number of therapeutic agents and known molecular targets in oncology makes the study and clinical use of biomarkers imperative for improving response and survival, reducing toxicity and ensuring economic sustainability. Colorectal cancer, among others, is at the forefront of development of predictive and prognostic biomarkers; however, the difficulty lies in translating potential biomarkers garnered from retrospective analyses in small numbers of patients to generalizable and affordable biomarkers used worldwide. This review outlines the progress made in prognostic and predictive biomarkers in advanced colorectal cancer (ACRC) from the early use of carcinoembryonic antigen (CEA) to the KRAS mutation and beyond. Future challenges are to incorporate standardized and validated methods preferentially during early phases of drug development linked with sophisticated biostatistical support. New trial designs focusing on biomarkers will be essential not only for better understanding of mechanisms of action, but also to make confident ‘go or no-go’ decisions. |
| first_indexed | 2024-03-12T19:56:19Z |
| format | Article |
| id | doaj.art-cc580985a53049f184f95db80a39dd9c |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T19:56:19Z |
| publishDate | 2011-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-cc580985a53049f184f95db80a39dd9c2023-08-02T02:48:10ZengMDPI AGCancers2072-66942011-04-01321844186010.3390/cancers3021844Biomarkers in Advanced Colorectal Cancer: Challenges in Translating Clinical Research into PracticeHendrik-Tobias ArkenauCharlotte LemechThe growing number of therapeutic agents and known molecular targets in oncology makes the study and clinical use of biomarkers imperative for improving response and survival, reducing toxicity and ensuring economic sustainability. Colorectal cancer, among others, is at the forefront of development of predictive and prognostic biomarkers; however, the difficulty lies in translating potential biomarkers garnered from retrospective analyses in small numbers of patients to generalizable and affordable biomarkers used worldwide. This review outlines the progress made in prognostic and predictive biomarkers in advanced colorectal cancer (ACRC) from the early use of carcinoembryonic antigen (CEA) to the KRAS mutation and beyond. Future challenges are to incorporate standardized and validated methods preferentially during early phases of drug development linked with sophisticated biostatistical support. New trial designs focusing on biomarkers will be essential not only for better understanding of mechanisms of action, but also to make confident ‘go or no-go’ decisions.http://www.mdpi.com/2072-6694/3/2/1844/prognostic biomarkerpredictive biomarkercolorectal cancerkras mutation |
| spellingShingle | Hendrik-Tobias Arkenau Charlotte Lemech Biomarkers in Advanced Colorectal Cancer: Challenges in Translating Clinical Research into Practice Cancers prognostic biomarker predictive biomarker colorectal cancer kras mutation |
| title | Biomarkers in Advanced Colorectal Cancer: Challenges in Translating Clinical Research into Practice |
| title_full | Biomarkers in Advanced Colorectal Cancer: Challenges in Translating Clinical Research into Practice |
| title_fullStr | Biomarkers in Advanced Colorectal Cancer: Challenges in Translating Clinical Research into Practice |
| title_full_unstemmed | Biomarkers in Advanced Colorectal Cancer: Challenges in Translating Clinical Research into Practice |
| title_short | Biomarkers in Advanced Colorectal Cancer: Challenges in Translating Clinical Research into Practice |
| title_sort | biomarkers in advanced colorectal cancer challenges in translating clinical research into practice |
| topic | prognostic biomarker predictive biomarker colorectal cancer kras mutation |
| url | http://www.mdpi.com/2072-6694/3/2/1844/ |
| work_keys_str_mv | AT hendriktobiasarkenau biomarkersinadvancedcolorectalcancerchallengesintranslatingclinicalresearchintopractice AT charlottelemech biomarkersinadvancedcolorectalcancerchallengesintranslatingclinicalresearchintopractice |