Triglyceride-glucose index level and variability and outcomes in patients with acute coronary syndrome undergoing percutaneous coronary intervention: an observational cohort study
Abstract Background The associations between the long-term triglyceride-glucose (TyG) index level and variability and clinical outcomes in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) have not been well studied. Methods A total of 1,694 ACS patients...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-12-01
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| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12944-022-01731-w |
| _version_ | 1811177900183912448 |
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| author | Yue Wang Yue Wang Shuaifeng Sun Xinyan Liu Wenxin Zhao Wenzheng Li Min Suo Zheng Wu Xiaofan Wu |
| author_facet | Yue Wang Yue Wang Shuaifeng Sun Xinyan Liu Wenxin Zhao Wenzheng Li Min Suo Zheng Wu Xiaofan Wu |
| author_sort | Yue Wang |
| collection | DOAJ |
| description | Abstract Background The associations between the long-term triglyceride-glucose (TyG) index level and variability and clinical outcomes in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) have not been well studied. Methods A total of 1,694 ACS patients with at least three postbaseline TyG index measurements within 2 years after PCI were included in the present study. The TyG index was defined as ln (fasting triglycerides [mg/dL] × fasting plasma glucose [mg/dL]/2). Multivariable-adjusted Cox proportional hazard models were used to examine the association between baseline and mean TyG index levels and TyG index variability and the risk of major adverse cardiovascular and cerebrovascular events (MACCEs). Results During the median follow-up of 31 months, the overall incidence of MACCE was 5.9%. Both high baseline and mean TyG index levels were independently associated with an increased risk of MACCEs after adjustment for multiple potential confounders (hazard ratio [HR) 1.76 95% confidence interval [CI] 1.06–2.93; and HR 2.73 95% CI 1.57–4.74). Similarly, higher TyG index variability by successive variation (SD) was well related to a higher prevalence of MACCEs (HR 2.17 95% CI 1.28–3.68). In addition, the mean TyG index level showed a stronger risk prediction for MACCEs than the baseline TyG index level and TyG index-SD (AUCs 0.618 vs 0.566 vs 0.566). Conclusions The risk of MACCEs significantly increased with higher baseline and mean TyG index levels, as well as TyG index variability, in patients with ACS undergoing PCI. In particular, the mean TyG index level exhibited the highest predicting ability for MACCEs. Therefore, monitoring the long-term pattern of the TyG index deserves attention in clinical practice. |
| first_indexed | 2024-04-11T06:10:08Z |
| format | Article |
| id | doaj.art-cc589d8695a1429e859c89d3dd3b29a1 |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-04-11T06:10:08Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-cc589d8695a1429e859c89d3dd3b29a12022-12-22T04:41:20ZengBMCLipids in Health and Disease1476-511X2022-12-0121111110.1186/s12944-022-01731-wTriglyceride-glucose index level and variability and outcomes in patients with acute coronary syndrome undergoing percutaneous coronary intervention: an observational cohort studyYue Wang0Yue Wang1Shuaifeng Sun2Xinyan Liu3Wenxin Zhao4Wenzheng Li5Min Suo6Zheng Wu7Xiaofan Wu8Integrated Ward of Cardiology, Beijing Anzhen Hospital, Capital Medical UniversityIntegrated Ward of Cardiology, Beijing Anzhen Hospital, Capital Medical UniversityIntegrated Ward of Cardiology, Beijing Anzhen Hospital, Capital Medical UniversityIntegrated Ward of Cardiology, Beijing Anzhen Hospital, Capital Medical UniversityIntegrated Ward of Cardiology, Beijing Anzhen Hospital, Capital Medical UniversityCenter for Coronary Artery Disease, Beijing Anzhen Hospital, Capital Medical UniversityIntegrated Ward of Cardiology, Beijing Anzhen Hospital, Capital Medical UniversityCenter for Coronary Artery Disease, Beijing Anzhen Hospital, Capital Medical UniversityIntegrated Ward of Cardiology, Beijing Anzhen Hospital, Capital Medical UniversityAbstract Background The associations between the long-term triglyceride-glucose (TyG) index level and variability and clinical outcomes in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) have not been well studied. Methods A total of 1,694 ACS patients with at least three postbaseline TyG index measurements within 2 years after PCI were included in the present study. The TyG index was defined as ln (fasting triglycerides [mg/dL] × fasting plasma glucose [mg/dL]/2). Multivariable-adjusted Cox proportional hazard models were used to examine the association between baseline and mean TyG index levels and TyG index variability and the risk of major adverse cardiovascular and cerebrovascular events (MACCEs). Results During the median follow-up of 31 months, the overall incidence of MACCE was 5.9%. Both high baseline and mean TyG index levels were independently associated with an increased risk of MACCEs after adjustment for multiple potential confounders (hazard ratio [HR) 1.76 95% confidence interval [CI] 1.06–2.93; and HR 2.73 95% CI 1.57–4.74). Similarly, higher TyG index variability by successive variation (SD) was well related to a higher prevalence of MACCEs (HR 2.17 95% CI 1.28–3.68). In addition, the mean TyG index level showed a stronger risk prediction for MACCEs than the baseline TyG index level and TyG index-SD (AUCs 0.618 vs 0.566 vs 0.566). Conclusions The risk of MACCEs significantly increased with higher baseline and mean TyG index levels, as well as TyG index variability, in patients with ACS undergoing PCI. In particular, the mean TyG index level exhibited the highest predicting ability for MACCEs. Therefore, monitoring the long-term pattern of the TyG index deserves attention in clinical practice.https://doi.org/10.1186/s12944-022-01731-wTriglyceride-glucose indexLevelVariabilityAcute coronary syndromePercutaneous coronary intervention |
| spellingShingle | Yue Wang Yue Wang Shuaifeng Sun Xinyan Liu Wenxin Zhao Wenzheng Li Min Suo Zheng Wu Xiaofan Wu Triglyceride-glucose index level and variability and outcomes in patients with acute coronary syndrome undergoing percutaneous coronary intervention: an observational cohort study Lipids in Health and Disease Triglyceride-glucose index Level Variability Acute coronary syndrome Percutaneous coronary intervention |
| title | Triglyceride-glucose index level and variability and outcomes in patients with acute coronary syndrome undergoing percutaneous coronary intervention: an observational cohort study |
| title_full | Triglyceride-glucose index level and variability and outcomes in patients with acute coronary syndrome undergoing percutaneous coronary intervention: an observational cohort study |
| title_fullStr | Triglyceride-glucose index level and variability and outcomes in patients with acute coronary syndrome undergoing percutaneous coronary intervention: an observational cohort study |
| title_full_unstemmed | Triglyceride-glucose index level and variability and outcomes in patients with acute coronary syndrome undergoing percutaneous coronary intervention: an observational cohort study |
| title_short | Triglyceride-glucose index level and variability and outcomes in patients with acute coronary syndrome undergoing percutaneous coronary intervention: an observational cohort study |
| title_sort | triglyceride glucose index level and variability and outcomes in patients with acute coronary syndrome undergoing percutaneous coronary intervention an observational cohort study |
| topic | Triglyceride-glucose index Level Variability Acute coronary syndrome Percutaneous coronary intervention |
| url | https://doi.org/10.1186/s12944-022-01731-w |
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