Megakaryocytes in Bone Metastasis: Protection or Progression?
Bone is the primary site where some cancers develop secondary growth, particularly those derived from breast and prostate tissue. The spread of metastasis to distant sites relies on complex mechanisms by which only cells endowed with certain characteristics are able to reach secondary growth sites....
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-02-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/8/2/134 |
| _version_ | 1797713174796959744 |
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| author | Paola Maroni |
| author_facet | Paola Maroni |
| author_sort | Paola Maroni |
| collection | DOAJ |
| description | Bone is the primary site where some cancers develop secondary growth, particularly those derived from breast and prostate tissue. The spread of metastasis to distant sites relies on complex mechanisms by which only cells endowed with certain characteristics are able to reach secondary growth sites. Platelets play a pivotal role in tumour growth, by conferring resistance to shear stress to the circulating tumour cells and protection against natural killer cell attack. Mature polyploid megakaryocytes (MKs) reside in close proximity to the vascular sinusoids of bone marrow, where their primary function is to produce platelets. Emerging evidence has demonstrated that MKs are essential for skeletal homeostasis, due to the expression and production of the bone-related proteins osteocalcin, osteonectin, bone morphogenetic protein, osteopontin, bone sialoprotein, and osteoprotegerin. Debate surrounds the role that MKs play in the development of bone metastasis, which is the topic of this mini-review. |
| first_indexed | 2024-03-12T07:32:41Z |
| format | Article |
| id | doaj.art-cc5aa3f573da4de7b79177bcbd8adda5 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T07:32:41Z |
| publishDate | 2019-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-cc5aa3f573da4de7b79177bcbd8adda52023-09-02T21:42:59ZengMDPI AGCells2073-44092019-02-018213410.3390/cells8020134cells8020134Megakaryocytes in Bone Metastasis: Protection or Progression?Paola Maroni0IRCCS Istituto Ortopedico Galeazzi, 20161 Milan, ItalyBone is the primary site where some cancers develop secondary growth, particularly those derived from breast and prostate tissue. The spread of metastasis to distant sites relies on complex mechanisms by which only cells endowed with certain characteristics are able to reach secondary growth sites. Platelets play a pivotal role in tumour growth, by conferring resistance to shear stress to the circulating tumour cells and protection against natural killer cell attack. Mature polyploid megakaryocytes (MKs) reside in close proximity to the vascular sinusoids of bone marrow, where their primary function is to produce platelets. Emerging evidence has demonstrated that MKs are essential for skeletal homeostasis, due to the expression and production of the bone-related proteins osteocalcin, osteonectin, bone morphogenetic protein, osteopontin, bone sialoprotein, and osteoprotegerin. Debate surrounds the role that MKs play in the development of bone metastasis, which is the topic of this mini-review.https://www.mdpi.com/2073-4409/8/2/134megakaryocytesbone metastasisbone marrowmicroenvironmentplatelets |
| spellingShingle | Paola Maroni Megakaryocytes in Bone Metastasis: Protection or Progression? Cells megakaryocytes bone metastasis bone marrow microenvironment platelets |
| title | Megakaryocytes in Bone Metastasis: Protection or Progression? |
| title_full | Megakaryocytes in Bone Metastasis: Protection or Progression? |
| title_fullStr | Megakaryocytes in Bone Metastasis: Protection or Progression? |
| title_full_unstemmed | Megakaryocytes in Bone Metastasis: Protection or Progression? |
| title_short | Megakaryocytes in Bone Metastasis: Protection or Progression? |
| title_sort | megakaryocytes in bone metastasis protection or progression |
| topic | megakaryocytes bone metastasis bone marrow microenvironment platelets |
| url | https://www.mdpi.com/2073-4409/8/2/134 |
| work_keys_str_mv | AT paolamaroni megakaryocytesinbonemetastasisprotectionorprogression |