The role of aryl hydrocarbon receptor in vitiligo: a review
Vitiligo is an acquired autoimmune dermatosis characterized by patchy skin depigmentation, causing significant psychological distress to the patients. Genetic susceptibility, environmental triggers, oxidative stress, and autoimmunity contribute to melanocyte destruction in vitiligo. Due to the diver...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-02-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1291556/full |
| _version_ | 1827364424445329408 |
|---|---|
| author | Yiting Li Yibin Zeng Zile Chen Xi Tan Xingyu Mei Zhouwei Wu |
| author_facet | Yiting Li Yibin Zeng Zile Chen Xi Tan Xingyu Mei Zhouwei Wu |
| author_sort | Yiting Li |
| collection | DOAJ |
| description | Vitiligo is an acquired autoimmune dermatosis characterized by patchy skin depigmentation, causing significant psychological distress to the patients. Genetic susceptibility, environmental triggers, oxidative stress, and autoimmunity contribute to melanocyte destruction in vitiligo. Due to the diversity and complexity of pathogenesis, the combination of inhibiting melanocyte destruction and stimulating melanogenesis gives the best results in treating vitiligo. The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that can regulate the expression of various downstream genes and play roles in cell differentiation, immune response, and physiological homeostasis maintenance. Recent studies suggested that AhR signaling pathway was downregulated in vitiligo. Activation of AhR pathway helps to activate antioxidant pathways, inhibit abnormal immunity response, and upregulate the melanogenesis gene, thereby protecting melanocytes from oxidative stress damage, controlling disease progression, and promoting lesion repigmentation. Here, we review the relevant literature and summarize the possible roles of the AhR signaling pathway in vitiligo pathogenesis and treatment, to further understand the links between the AhR and vitiligo, and provide new potential therapeutic strategies. |
| first_indexed | 2024-03-08T08:08:50Z |
| format | Article |
| id | doaj.art-cc5cd558473846b88d1dbd4706d7830a |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-08T08:08:50Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-cc5cd558473846b88d1dbd4706d7830a2024-02-02T09:46:27ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-02-011510.3389/fimmu.2024.12915561291556The role of aryl hydrocarbon receptor in vitiligo: a reviewYiting Li0Yibin Zeng1Zile Chen2Xi Tan3Xingyu Mei4Zhouwei Wu5Department of Dermatology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Dermatology, Minhang Hospital, Fudan University, Shanghai, ChinaDepartment of Dermatology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Dermatology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Dermatology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Dermatology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaVitiligo is an acquired autoimmune dermatosis characterized by patchy skin depigmentation, causing significant psychological distress to the patients. Genetic susceptibility, environmental triggers, oxidative stress, and autoimmunity contribute to melanocyte destruction in vitiligo. Due to the diversity and complexity of pathogenesis, the combination of inhibiting melanocyte destruction and stimulating melanogenesis gives the best results in treating vitiligo. The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that can regulate the expression of various downstream genes and play roles in cell differentiation, immune response, and physiological homeostasis maintenance. Recent studies suggested that AhR signaling pathway was downregulated in vitiligo. Activation of AhR pathway helps to activate antioxidant pathways, inhibit abnormal immunity response, and upregulate the melanogenesis gene, thereby protecting melanocytes from oxidative stress damage, controlling disease progression, and promoting lesion repigmentation. Here, we review the relevant literature and summarize the possible roles of the AhR signaling pathway in vitiligo pathogenesis and treatment, to further understand the links between the AhR and vitiligo, and provide new potential therapeutic strategies.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1291556/fullaryl hydrocarbon receptorvitiligooxidative stressimmunity modulationmelanogenesis |
| spellingShingle | Yiting Li Yibin Zeng Zile Chen Xi Tan Xingyu Mei Zhouwei Wu The role of aryl hydrocarbon receptor in vitiligo: a review Frontiers in Immunology aryl hydrocarbon receptor vitiligo oxidative stress immunity modulation melanogenesis |
| title | The role of aryl hydrocarbon receptor in vitiligo: a review |
| title_full | The role of aryl hydrocarbon receptor in vitiligo: a review |
| title_fullStr | The role of aryl hydrocarbon receptor in vitiligo: a review |
| title_full_unstemmed | The role of aryl hydrocarbon receptor in vitiligo: a review |
| title_short | The role of aryl hydrocarbon receptor in vitiligo: a review |
| title_sort | role of aryl hydrocarbon receptor in vitiligo a review |
| topic | aryl hydrocarbon receptor vitiligo oxidative stress immunity modulation melanogenesis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1291556/full |
| work_keys_str_mv | AT yitingli theroleofarylhydrocarbonreceptorinvitiligoareview AT yibinzeng theroleofarylhydrocarbonreceptorinvitiligoareview AT zilechen theroleofarylhydrocarbonreceptorinvitiligoareview AT xitan theroleofarylhydrocarbonreceptorinvitiligoareview AT xingyumei theroleofarylhydrocarbonreceptorinvitiligoareview AT zhouweiwu theroleofarylhydrocarbonreceptorinvitiligoareview AT yitingli roleofarylhydrocarbonreceptorinvitiligoareview AT yibinzeng roleofarylhydrocarbonreceptorinvitiligoareview AT zilechen roleofarylhydrocarbonreceptorinvitiligoareview AT xitan roleofarylhydrocarbonreceptorinvitiligoareview AT xingyumei roleofarylhydrocarbonreceptorinvitiligoareview AT zhouweiwu roleofarylhydrocarbonreceptorinvitiligoareview |