Systemic immune-inflammation index and in-stent restenosis in patients with acute coronary syndrome: a single-center retrospective study
Abstract Background In-stent restenosis (ISR) has been shown to be correlated with inflammation. This study aimed to examine the relationship between systemic immune-inflammation index (SII, an innovative inflammatory biomarker) and ISR in acute coronary syndrome (ACS) patients after drug-eluting st...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-02-01
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| Series: | European Journal of Medical Research |
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| Online Access: | https://doi.org/10.1186/s40001-024-01736-4 |
| _version_ | 1797275373954662400 |
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| author | Feng Xie Zuozhong Yu Yurong Xiong Zhijian Wu Yanqing Wu |
| author_facet | Feng Xie Zuozhong Yu Yurong Xiong Zhijian Wu Yanqing Wu |
| author_sort | Feng Xie |
| collection | DOAJ |
| description | Abstract Background In-stent restenosis (ISR) has been shown to be correlated with inflammation. This study aimed to examine the relationship between systemic immune-inflammation index (SII, an innovative inflammatory biomarker) and ISR in acute coronary syndrome (ACS) patients after drug-eluting stent (DES) implantation. Methods Subjects who were diagnosed with ACS and underwent DES implantation were enrolled retrospectively. All individuals underwent follow-up coronary angiography at six to forty-eight months after percutaneous coronary intervention (PCI). SII was defined as [(platelet count × neutrophil count)/lymphocyte count], and Ln-transformed SII (LnSII) was carried out for our analysis. Multivariate logistic regression analysis was employed to assess the association between LnSII and DES-ISR. Results During a median follow-up period of 12 (11, 20) months, 523 ACS patients who underwent follow-up angiography were included. The incidence of DES-ISR was 11.28%, and patients in the higher LnSII tertile trended to show higher likelihoods of ISR (5.7% vs. 12.1% vs. 16.0%; P = 0.009). Moreover, each unit of increased LnSII was correlated with a 69% increased risk of DES-ISR (OR = 1.69, 95% CI 1.04–2.75). After final adjusting for confounders, a significant higher risk of DES-ISR (OR = 2.52, 95% CI 1.23–5.17) was found in participants in tertile 3 (≥ 6.7), compared with those in tertiles 1–2 (< 6.7). Subgroup analysis showed no significant dependence on age, gender, body mass index, current smoking, hypertension, and diabetes for this positive association (all P for interaction > 0.05). Conclusion High levels of SII were independently associated with an increased risk of DES-ISR in ACS patients who underwent PCI. Further prospective cohort studies are still needed to validate our findings. |
| first_indexed | 2024-03-07T15:13:26Z |
| format | Article |
| id | doaj.art-cc5db2a7e3504ca388b506472cc11f6f |
| institution | Directory Open Access Journal |
| issn | 2047-783X |
| language | English |
| last_indexed | 2024-03-07T15:13:26Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj.art-cc5db2a7e3504ca388b506472cc11f6f2024-03-05T18:04:21ZengBMCEuropean Journal of Medical Research2047-783X2024-02-0129111010.1186/s40001-024-01736-4Systemic immune-inflammation index and in-stent restenosis in patients with acute coronary syndrome: a single-center retrospective studyFeng Xie0Zuozhong Yu1Yurong Xiong2Zhijian Wu3Yanqing Wu4Department of Cardiology, the Second Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Cardiology, the Second Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Cardiology, the Second Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Cardiology, the Second Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Cardiology, the Second Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityAbstract Background In-stent restenosis (ISR) has been shown to be correlated with inflammation. This study aimed to examine the relationship between systemic immune-inflammation index (SII, an innovative inflammatory biomarker) and ISR in acute coronary syndrome (ACS) patients after drug-eluting stent (DES) implantation. Methods Subjects who were diagnosed with ACS and underwent DES implantation were enrolled retrospectively. All individuals underwent follow-up coronary angiography at six to forty-eight months after percutaneous coronary intervention (PCI). SII was defined as [(platelet count × neutrophil count)/lymphocyte count], and Ln-transformed SII (LnSII) was carried out for our analysis. Multivariate logistic regression analysis was employed to assess the association between LnSII and DES-ISR. Results During a median follow-up period of 12 (11, 20) months, 523 ACS patients who underwent follow-up angiography were included. The incidence of DES-ISR was 11.28%, and patients in the higher LnSII tertile trended to show higher likelihoods of ISR (5.7% vs. 12.1% vs. 16.0%; P = 0.009). Moreover, each unit of increased LnSII was correlated with a 69% increased risk of DES-ISR (OR = 1.69, 95% CI 1.04–2.75). After final adjusting for confounders, a significant higher risk of DES-ISR (OR = 2.52, 95% CI 1.23–5.17) was found in participants in tertile 3 (≥ 6.7), compared with those in tertiles 1–2 (< 6.7). Subgroup analysis showed no significant dependence on age, gender, body mass index, current smoking, hypertension, and diabetes for this positive association (all P for interaction > 0.05). Conclusion High levels of SII were independently associated with an increased risk of DES-ISR in ACS patients who underwent PCI. Further prospective cohort studies are still needed to validate our findings.https://doi.org/10.1186/s40001-024-01736-4In-stent restenosisDrug-eluting stentsSystemic immune-inflammation indexAcute coronary syndromePercutaneous coronary intervention |
| spellingShingle | Feng Xie Zuozhong Yu Yurong Xiong Zhijian Wu Yanqing Wu Systemic immune-inflammation index and in-stent restenosis in patients with acute coronary syndrome: a single-center retrospective study European Journal of Medical Research In-stent restenosis Drug-eluting stents Systemic immune-inflammation index Acute coronary syndrome Percutaneous coronary intervention |
| title | Systemic immune-inflammation index and in-stent restenosis in patients with acute coronary syndrome: a single-center retrospective study |
| title_full | Systemic immune-inflammation index and in-stent restenosis in patients with acute coronary syndrome: a single-center retrospective study |
| title_fullStr | Systemic immune-inflammation index and in-stent restenosis in patients with acute coronary syndrome: a single-center retrospective study |
| title_full_unstemmed | Systemic immune-inflammation index and in-stent restenosis in patients with acute coronary syndrome: a single-center retrospective study |
| title_short | Systemic immune-inflammation index and in-stent restenosis in patients with acute coronary syndrome: a single-center retrospective study |
| title_sort | systemic immune inflammation index and in stent restenosis in patients with acute coronary syndrome a single center retrospective study |
| topic | In-stent restenosis Drug-eluting stents Systemic immune-inflammation index Acute coronary syndrome Percutaneous coronary intervention |
| url | https://doi.org/10.1186/s40001-024-01736-4 |
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