Memantine protects thalamocortical hyper‐glutamatergic transmission induced by NMDA receptor antagonism via activation of system xc−

Memantine protects thalamocortical hyper‐glutamatergic transmission induced by NMDA receptor antagonism via activation of system xc−

Abstract Deficiencies in N‐methyl‐d‐aspartate (NMDA)/glutamate receptor (NMDAR) signaling have been considered central to the cognitive impairments of schizophrenia; however, an NMDAR antagonist memantine (MEM) improves cognitive impairments of Alzheimer's disease and schizophrenia. These mecha...

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Bibliographic Details
Main Authors: Motohiro Okada, Kouji Fukuyama, Yasuhiro Kawano, Takashi Shiroyama, Yuto Ueda
Format: Article
Language:English
Published: Wiley 2019-02-01
Series:Pharmacology Research & Perspectives
Subjects:
cystine/glutamate antiporter
mediodorsal thalamic nucleus
memantine
schizophrenia
Online Access:https://doi.org/10.1002/prp2.457

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