Assessment of interleukin 6 (IL-6) as a marker of inflammation among adult patients with pulmonary tuberculosis in Zaria, Nigeria
Abstract Tuberculosis (TB) remains a significant cause of morbidity and mortality worldwide. Complications of the disease are associated with the host’s inflammatory response. The study aimed to determine the plasma level of interleukin-6 as a biomarker of inflammation among adult patients with pulm...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2024-01-01
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| Series: | The Egyptian Journal of Bronchology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43168-024-00263-4 |
| _version_ | 1797275574172909568 |
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| author | Mairiga Sa’ad Abdullah A. Abba Bolanle Olufunke Priscilla Musa Abdurrahman El-fulaty Ahmad Musa Mohammed |
| author_facet | Mairiga Sa’ad Abdullah A. Abba Bolanle Olufunke Priscilla Musa Abdurrahman El-fulaty Ahmad Musa Mohammed |
| author_sort | Mairiga Sa’ad |
| collection | DOAJ |
| description | Abstract Tuberculosis (TB) remains a significant cause of morbidity and mortality worldwide. Complications of the disease are associated with the host’s inflammatory response. The study aimed to determine the plasma level of interleukin-6 as a biomarker of inflammation among adult patients with pulmonary tuberculosis in Zaria. Method This was a cross-sectional study. Blood samples were taken from 30 treatment-naïve (TN), 30 treatment-experienced (TE), and 30 healthy controls (HC). Results The means and standard deviations of interleukin-6 plasma levels for tuberculosis treatment naive, treatment experience and apparently healthy control are 64.4 ± 19.4, 57.9 ± 21.4, and 49.9 ± 7.7 pg/L, respectively. This study found upregulated plasma levels of interleukin-6 among treatment naive compared to treatment experience but the statistically not significant and significantly upregulated level of interleukin 6 among treatment naïve compared to apparently healthy control (p = 0.006). There was a downregulated level of interleukin-6 among HC compared to TN and TE but statistically not significant. Conclusion The role of interleukin-6 as a surrogate biomarker for the management of patients with pulmonary tuberculosis is promising but requires further study. |
| first_indexed | 2024-03-07T15:16:24Z |
| format | Article |
| id | doaj.art-cc5f78e06a694a439fc207a53aac27b4 |
| institution | Directory Open Access Journal |
| issn | 2314-8551 |
| language | English |
| last_indexed | 2024-03-07T15:16:24Z |
| publishDate | 2024-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Bronchology |
| spelling | doaj.art-cc5f78e06a694a439fc207a53aac27b42024-03-05T17:55:16ZengSpringerOpenThe Egyptian Journal of Bronchology2314-85512024-01-011811610.1186/s43168-024-00263-4Assessment of interleukin 6 (IL-6) as a marker of inflammation among adult patients with pulmonary tuberculosis in Zaria, NigeriaMairiga Sa’ad0Abdullah A. Abba1Bolanle Olufunke Priscilla Musa2Abdurrahman El-fulaty Ahmad3Musa Mohammed4Department of Medicine, Immunology Unit, Ahmadu Bello UniversityDepartment of Medicine, Pulmunonology Unit, Ahmadu Bello UniversityDepartment of Medicine, Immunology Unit, Ahmadu Bello UniversityDepartment of Medicine, Immunology Unit, Ahmadu Bello UniversityDepartment of Medicine, Immunology Unit, Ahmadu Bello UniversityAbstract Tuberculosis (TB) remains a significant cause of morbidity and mortality worldwide. Complications of the disease are associated with the host’s inflammatory response. The study aimed to determine the plasma level of interleukin-6 as a biomarker of inflammation among adult patients with pulmonary tuberculosis in Zaria. Method This was a cross-sectional study. Blood samples were taken from 30 treatment-naïve (TN), 30 treatment-experienced (TE), and 30 healthy controls (HC). Results The means and standard deviations of interleukin-6 plasma levels for tuberculosis treatment naive, treatment experience and apparently healthy control are 64.4 ± 19.4, 57.9 ± 21.4, and 49.9 ± 7.7 pg/L, respectively. This study found upregulated plasma levels of interleukin-6 among treatment naive compared to treatment experience but the statistically not significant and significantly upregulated level of interleukin 6 among treatment naïve compared to apparently healthy control (p = 0.006). There was a downregulated level of interleukin-6 among HC compared to TN and TE but statistically not significant. Conclusion The role of interleukin-6 as a surrogate biomarker for the management of patients with pulmonary tuberculosis is promising but requires further study.https://doi.org/10.1186/s43168-024-00263-4InterleukinTuberculosisBiomarkerInflammation |
| spellingShingle | Mairiga Sa’ad Abdullah A. Abba Bolanle Olufunke Priscilla Musa Abdurrahman El-fulaty Ahmad Musa Mohammed Assessment of interleukin 6 (IL-6) as a marker of inflammation among adult patients with pulmonary tuberculosis in Zaria, Nigeria The Egyptian Journal of Bronchology Interleukin Tuberculosis Biomarker Inflammation |
| title | Assessment of interleukin 6 (IL-6) as a marker of inflammation among adult patients with pulmonary tuberculosis in Zaria, Nigeria |
| title_full | Assessment of interleukin 6 (IL-6) as a marker of inflammation among adult patients with pulmonary tuberculosis in Zaria, Nigeria |
| title_fullStr | Assessment of interleukin 6 (IL-6) as a marker of inflammation among adult patients with pulmonary tuberculosis in Zaria, Nigeria |
| title_full_unstemmed | Assessment of interleukin 6 (IL-6) as a marker of inflammation among adult patients with pulmonary tuberculosis in Zaria, Nigeria |
| title_short | Assessment of interleukin 6 (IL-6) as a marker of inflammation among adult patients with pulmonary tuberculosis in Zaria, Nigeria |
| title_sort | assessment of interleukin 6 il 6 as a marker of inflammation among adult patients with pulmonary tuberculosis in zaria nigeria |
| topic | Interleukin Tuberculosis Biomarker Inflammation |
| url | https://doi.org/10.1186/s43168-024-00263-4 |
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