Effects of wolfberry (Lycium barbarum) consumption on the human plasma lipidome and its association with cardiovascular disease risk factors: a randomized controlled trial of middle-aged and older adults
BackgroundLong-term wolfberry intake as part of a healthy dietary pattern was recognized to have beneficial vascular outcomes. Characterization of the plasma lipidome may further provide comprehensive insights into pathways underlying these cardiovascular protective effects.ObjectiveWe analyzed the...
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2024.1258570/full |
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| author | Darel Wee Kiat Toh Hanzhang Zhou Amaury Cazenave-Gassiot Amaury Cazenave-Gassiot Hyungwon Choi Bo Burla Anne Katherin Bendt Markus R. Wenk Markus R. Wenk Lieng Hsi Ling Lieng Hsi Ling Jung Eun Kim |
| author_facet | Darel Wee Kiat Toh Hanzhang Zhou Amaury Cazenave-Gassiot Amaury Cazenave-Gassiot Hyungwon Choi Bo Burla Anne Katherin Bendt Markus R. Wenk Markus R. Wenk Lieng Hsi Ling Lieng Hsi Ling Jung Eun Kim |
| author_sort | Darel Wee Kiat Toh |
| collection | DOAJ |
| description | BackgroundLong-term wolfberry intake as part of a healthy dietary pattern was recognized to have beneficial vascular outcomes. Characterization of the plasma lipidome may further provide comprehensive insights into pathways underlying these cardiovascular protective effects.ObjectiveWe analyzed the plasma lipidome of subjects who adhered to a healthy dietary pattern either with or without wolfberry and investigated the associations between the plasma lipidomic profile and cardiovascular health-related indicators.MethodsIn this 16-week, parallel design, randomized controlled trial, middle-aged and older adults (n = 41) were provided dietary counseling and assigned to either consume or not consume 15 g of wolfberry daily. At baseline and post-intervention, plasma lipidomics was assayed, and its relationships with classical CVD risk factors, vascular health, oxidant burden, carotenoids status, body composition, and anthropometry were examined.ResultsFrom the plasma lipidome, 427 lipid species from 26 sub-classes were quantified. In the wolfberry and control groups, significant changes were prominent for 27 and 42 lipid species, respectively (P < 0.05 with > 0.2-fold change). Fold changes for seven lipid species were also markedly different between the two groups. Examining the relationships between the plasma lipidome and CVD-related risk factors, total cholesterol revealed a marked positive correlation with 13 ceramide species, while HDL-cholesterol which was notably increased with wolfberry consumption showed a positive correlation with 10 phosphatidylcholine species. Oxidant burden, as represented by plasma 8-isoprostanes, was also inversely associated with lipidomic triglycerides and ether-triglycerides (41 species) and directly associated with hexosylceramides (eight species) and sphingomyelins (six species). There were no differential associations with CVD risk detected between groups.ConclusionCharacteristic alterations to the plasma lipidome were observed with healthy dietary pattern adherence and wolfberry consumption. An examination of these fluctuations suggests potential biochemical mechanisms that may mediate the antioxidant and cardiovascular protective effects of healthy dietary pattern adherence and wolfberry intake. This study was registered at clinicaltrials.gov as NCT0353584. |
| first_indexed | 2024-03-07T23:30:58Z |
| format | Article |
| id | doaj.art-cc6148dff03846d4a21d2cd3f74b6129 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-03-07T23:30:58Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Nutrition |
| spelling | doaj.art-cc6148dff03846d4a21d2cd3f74b61292024-02-20T14:13:48ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2024-02-011110.3389/fnut.2024.12585701258570Effects of wolfberry (Lycium barbarum) consumption on the human plasma lipidome and its association with cardiovascular disease risk factors: a randomized controlled trial of middle-aged and older adultsDarel Wee Kiat Toh0Hanzhang Zhou1Amaury Cazenave-Gassiot2Amaury Cazenave-Gassiot3Hyungwon Choi4Bo Burla5Anne Katherin Bendt6Markus R. Wenk7Markus R. Wenk8Lieng Hsi Ling9Lieng Hsi Ling10Jung Eun Kim11Department of Food Science and Technology, Faculty of Science, National University of Singapore, Singapore, SingaporeDepartment of Food Science and Technology, Faculty of Science, National University of Singapore, Singapore, SingaporeDepartment of Biochemistry and Precision Medicine TRP, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeSingapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore, SingaporeDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeSingapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore, SingaporeSingapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore, SingaporeDepartment of Biochemistry and Precision Medicine TRP, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeSingapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore, SingaporeDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeDepartment of Cardiology, National University Heart Centre, Singapore, SingaporeDepartment of Food Science and Technology, Faculty of Science, National University of Singapore, Singapore, SingaporeBackgroundLong-term wolfberry intake as part of a healthy dietary pattern was recognized to have beneficial vascular outcomes. Characterization of the plasma lipidome may further provide comprehensive insights into pathways underlying these cardiovascular protective effects.ObjectiveWe analyzed the plasma lipidome of subjects who adhered to a healthy dietary pattern either with or without wolfberry and investigated the associations between the plasma lipidomic profile and cardiovascular health-related indicators.MethodsIn this 16-week, parallel design, randomized controlled trial, middle-aged and older adults (n = 41) were provided dietary counseling and assigned to either consume or not consume 15 g of wolfberry daily. At baseline and post-intervention, plasma lipidomics was assayed, and its relationships with classical CVD risk factors, vascular health, oxidant burden, carotenoids status, body composition, and anthropometry were examined.ResultsFrom the plasma lipidome, 427 lipid species from 26 sub-classes were quantified. In the wolfberry and control groups, significant changes were prominent for 27 and 42 lipid species, respectively (P < 0.05 with > 0.2-fold change). Fold changes for seven lipid species were also markedly different between the two groups. Examining the relationships between the plasma lipidome and CVD-related risk factors, total cholesterol revealed a marked positive correlation with 13 ceramide species, while HDL-cholesterol which was notably increased with wolfberry consumption showed a positive correlation with 10 phosphatidylcholine species. Oxidant burden, as represented by plasma 8-isoprostanes, was also inversely associated with lipidomic triglycerides and ether-triglycerides (41 species) and directly associated with hexosylceramides (eight species) and sphingomyelins (six species). There were no differential associations with CVD risk detected between groups.ConclusionCharacteristic alterations to the plasma lipidome were observed with healthy dietary pattern adherence and wolfberry consumption. An examination of these fluctuations suggests potential biochemical mechanisms that may mediate the antioxidant and cardiovascular protective effects of healthy dietary pattern adherence and wolfberry intake. This study was registered at clinicaltrials.gov as NCT0353584.https://www.frontiersin.org/articles/10.3389/fnut.2024.1258570/fullantioxidantcardiovascular diseasehealthy dietlipidomicslipidslipoproteins |
| spellingShingle | Darel Wee Kiat Toh Hanzhang Zhou Amaury Cazenave-Gassiot Amaury Cazenave-Gassiot Hyungwon Choi Bo Burla Anne Katherin Bendt Markus R. Wenk Markus R. Wenk Lieng Hsi Ling Lieng Hsi Ling Jung Eun Kim Effects of wolfberry (Lycium barbarum) consumption on the human plasma lipidome and its association with cardiovascular disease risk factors: a randomized controlled trial of middle-aged and older adults Frontiers in Nutrition antioxidant cardiovascular disease healthy diet lipidomics lipids lipoproteins |
| title | Effects of wolfberry (Lycium barbarum) consumption on the human plasma lipidome and its association with cardiovascular disease risk factors: a randomized controlled trial of middle-aged and older adults |
| title_full | Effects of wolfberry (Lycium barbarum) consumption on the human plasma lipidome and its association with cardiovascular disease risk factors: a randomized controlled trial of middle-aged and older adults |
| title_fullStr | Effects of wolfberry (Lycium barbarum) consumption on the human plasma lipidome and its association with cardiovascular disease risk factors: a randomized controlled trial of middle-aged and older adults |
| title_full_unstemmed | Effects of wolfberry (Lycium barbarum) consumption on the human plasma lipidome and its association with cardiovascular disease risk factors: a randomized controlled trial of middle-aged and older adults |
| title_short | Effects of wolfberry (Lycium barbarum) consumption on the human plasma lipidome and its association with cardiovascular disease risk factors: a randomized controlled trial of middle-aged and older adults |
| title_sort | effects of wolfberry lycium barbarum consumption on the human plasma lipidome and its association with cardiovascular disease risk factors a randomized controlled trial of middle aged and older adults |
| topic | antioxidant cardiovascular disease healthy diet lipidomics lipids lipoproteins |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2024.1258570/full |
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