Association of triglyceride-glucose index with the prevalence of cardiovascular disease in malnourished/non-malnourished patients: a large cross-sectional study
BackgroundNumerous investigations have demonstrated a strong association between the TyG (triglyceride-glucose) index, which is derived from lipid and glucose levels in the bloodstream, and the onset and progression of cardiovascular diseases (CVD). Blood glucose and blood lipids are affected by nut...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1306415/full |
| _version_ | 1797449234678546432 |
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| author | Xiaobo Jiang Jiabin Tu Sicong Chen Yanbin Zhang Weilong Qiu Kaihong Chen Liling Chen Bo Wu |
| author_facet | Xiaobo Jiang Jiabin Tu Sicong Chen Yanbin Zhang Weilong Qiu Kaihong Chen Liling Chen Bo Wu |
| author_sort | Xiaobo Jiang |
| collection | DOAJ |
| description | BackgroundNumerous investigations have demonstrated a strong association between the TyG (triglyceride-glucose) index, which is derived from lipid and glucose levels in the bloodstream, and the onset and progression of cardiovascular diseases (CVD). Blood glucose and blood lipids are affected by nutritional status, and few studies have explored whether the correlation between TyG index and the risk of CVD is affected by nutritional status.AimsTo investigate the connection between TyG index and the risk of CVD among individuals with varying nutritional statuses.MethodA total of 19,847 were included in the analysis, of which 15,955 participants were non-malnourished and 3,892 patients were malnourished. According to the TyG index quartile, the patients were categorized into four groups. Logistic regression analysis and restricted cubic spline was used to study the relationship between TyG index and the risk of CVD in normal and malnourished populations.ResultsThe results of the restricted cubic spline showed that the TyG index was positively associated with the risk of CVD in the non-malnourished population. The TyG index showed a U-shaped association with the risk of CVD in malnourished people. The result is consistent with that of logistic regression (Malnutrition: Group 2: OR: 1.14; 95% CI: 0.85–1.53; Group 3: OR: 1.36; 95% CI: 1.03–1.79; Group 4: OR: 1.72; 95% CI:1.31–2.25, P for trend <0.001; Non-malnutrition: Group 2: OR: 0.82; 95% CI: 0.46–1.48; Group 3: OR: 0.88; 95% CI: 0.49–1.57; Group 4: OR: 1.45; 95% CI:0.83–2.52, P for trend =0.067).ConclusionsThe association between the TyG index and the risk of CVD varied depending on the nutritional states. When using TyG index to assess the risk of CVD, stratification combined with nutritional status helps to more accurately screen patients at high risk of CVD. |
| first_indexed | 2024-03-09T14:22:06Z |
| format | Article |
| id | doaj.art-cc61d560191342799c7305aa50260daf |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-03-09T14:22:06Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-cc61d560191342799c7305aa50260daf2023-11-28T10:01:10ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-11-011010.3389/fcvm.2023.13064151306415Association of triglyceride-glucose index with the prevalence of cardiovascular disease in malnourished/non-malnourished patients: a large cross-sectional studyXiaobo JiangJiabin TuSicong ChenYanbin ZhangWeilong QiuKaihong ChenLiling ChenBo WuBackgroundNumerous investigations have demonstrated a strong association between the TyG (triglyceride-glucose) index, which is derived from lipid and glucose levels in the bloodstream, and the onset and progression of cardiovascular diseases (CVD). Blood glucose and blood lipids are affected by nutritional status, and few studies have explored whether the correlation between TyG index and the risk of CVD is affected by nutritional status.AimsTo investigate the connection between TyG index and the risk of CVD among individuals with varying nutritional statuses.MethodA total of 19,847 were included in the analysis, of which 15,955 participants were non-malnourished and 3,892 patients were malnourished. According to the TyG index quartile, the patients were categorized into four groups. Logistic regression analysis and restricted cubic spline was used to study the relationship between TyG index and the risk of CVD in normal and malnourished populations.ResultsThe results of the restricted cubic spline showed that the TyG index was positively associated with the risk of CVD in the non-malnourished population. The TyG index showed a U-shaped association with the risk of CVD in malnourished people. The result is consistent with that of logistic regression (Malnutrition: Group 2: OR: 1.14; 95% CI: 0.85–1.53; Group 3: OR: 1.36; 95% CI: 1.03–1.79; Group 4: OR: 1.72; 95% CI:1.31–2.25, P for trend <0.001; Non-malnutrition: Group 2: OR: 0.82; 95% CI: 0.46–1.48; Group 3: OR: 0.88; 95% CI: 0.49–1.57; Group 4: OR: 1.45; 95% CI:0.83–2.52, P for trend =0.067).ConclusionsThe association between the TyG index and the risk of CVD varied depending on the nutritional states. When using TyG index to assess the risk of CVD, stratification combined with nutritional status helps to more accurately screen patients at high risk of CVD.https://www.frontiersin.org/articles/10.3389/fcvm.2023.1306415/fulltriglyceride-glucose indexcardiovascular diseasemalnutritioninsulin resistanceNHANES |
| spellingShingle | Xiaobo Jiang Jiabin Tu Sicong Chen Yanbin Zhang Weilong Qiu Kaihong Chen Liling Chen Bo Wu Association of triglyceride-glucose index with the prevalence of cardiovascular disease in malnourished/non-malnourished patients: a large cross-sectional study Frontiers in Cardiovascular Medicine triglyceride-glucose index cardiovascular disease malnutrition insulin resistance NHANES |
| title | Association of triglyceride-glucose index with the prevalence of cardiovascular disease in malnourished/non-malnourished patients: a large cross-sectional study |
| title_full | Association of triglyceride-glucose index with the prevalence of cardiovascular disease in malnourished/non-malnourished patients: a large cross-sectional study |
| title_fullStr | Association of triglyceride-glucose index with the prevalence of cardiovascular disease in malnourished/non-malnourished patients: a large cross-sectional study |
| title_full_unstemmed | Association of triglyceride-glucose index with the prevalence of cardiovascular disease in malnourished/non-malnourished patients: a large cross-sectional study |
| title_short | Association of triglyceride-glucose index with the prevalence of cardiovascular disease in malnourished/non-malnourished patients: a large cross-sectional study |
| title_sort | association of triglyceride glucose index with the prevalence of cardiovascular disease in malnourished non malnourished patients a large cross sectional study |
| topic | triglyceride-glucose index cardiovascular disease malnutrition insulin resistance NHANES |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1306415/full |
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