Effects of glycine 64 substitutions in RNA-dependent RNA polymerase on ribavirin sensitivity and pathogenicity of coxsackievirus A6

Effects of glycine 64 substitutions in RNA-dependent RNA polymerase on ribavirin sensitivity and pathogenicity of coxsackievirus A6

Hand, foot, and mouth disease (HFMD) caused by a group of enteroviruses is a global public health problem. In recent years, coxsackievirus A6 (CVA6) has emerged as an important HFMD agent. Previous studies have shown that mutations of glycine 64 in RNA-dependent RNA polymerase (3D polymerase), which...

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Bibliographic Details
Main Authors: Rui Wang, Qiang Sun, Jinbo Xiao, Congcong Wang, Xiaoliang Li, Jichen Li, Yang Song, Huanhuan Lu, Ying Liu, Shuangli Zhu, Zhijun Liu, Yong Zhang
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Virus Research
Subjects:
Coxsackievirus A6
3D polymerase
Glycine 64
Replication fidelity
Attenuated virulence
Ribavirin insensitivity
Online Access:http://www.sciencedirect.com/science/article/pii/S0168170223002307

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http://www.sciencedirect.com/science/article/pii/S0168170223002307

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