A Case of Recalcitrant Circinate Generalized (Lapière) Psoriasis Successfully Treated with Risankizumab
Circinate (Lapière) psoriasis represents a rare variety of generalized subacute pustular psoriasis clinically characterized by rapid onset of annular circinate lesions with micro-pustules at the borders without classic plaque psoriasis manifestations. Most reported cases have been described in child...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2022-05-01
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| Series: | Case Reports in Dermatology |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/523756 |
| _version_ | 1811240303018901504 |
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| author | Angelo Ruggiero Wanda Lauro Gabriella Fabbrocini Chiara Miano Alessia Villani Claudio Marasca |
| author_facet | Angelo Ruggiero Wanda Lauro Gabriella Fabbrocini Chiara Miano Alessia Villani Claudio Marasca |
| author_sort | Angelo Ruggiero |
| collection | DOAJ |
| description | Circinate (Lapière) psoriasis represents a rare variety of generalized subacute pustular psoriasis clinically characterized by rapid onset of annular circinate lesions with micro-pustules at the borders without classic plaque psoriasis manifestations. Most reported cases have been described in childhood with a relative benign course, fast and long-term remission after treatment. However, the recalcitrant course may result in an important negative impact on patients’ quality of life. Many systemic treatments have been reported for the management of moderate to severe forms, with variable clinical outcomes. However, data about the use of biologics in this rare psoriasis subtype are still lacking. Herein, we report the first case of circinate psoriasis unresponsive to methotrexate and almost all classes of biologics approved for psoriasis (anti-tumour necrosis factor (TNF), anti-interleukin (IL)-12/23, and anti-IL-17) which was successfully treated with risankizumab (anti-IL-23). |
| first_indexed | 2024-04-12T13:17:47Z |
| format | Article |
| id | doaj.art-cc62afa29bd547b9b5a21c79bc775981 |
| institution | Directory Open Access Journal |
| issn | 1662-6567 |
| language | English |
| last_indexed | 2024-04-12T13:17:47Z |
| publishDate | 2022-05-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Dermatology |
| spelling | doaj.art-cc62afa29bd547b9b5a21c79bc7759812022-12-22T03:31:39ZengKarger PublishersCase Reports in Dermatology1662-65672022-05-0114213814310.1159/000523756523756A Case of Recalcitrant Circinate Generalized (Lapière) Psoriasis Successfully Treated with RisankizumabAngelo Ruggierohttps://orcid.org/0000-0002-4658-7391Wanda Laurohttps://orcid.org/0000-0001-9212-6601Gabriella Fabbrocinihttps://orcid.org/0000-0002-0064-1874Chiara MianoAlessia VillaniClaudio Marascahttps://orcid.org/0000-0002-8401-5730Circinate (Lapière) psoriasis represents a rare variety of generalized subacute pustular psoriasis clinically characterized by rapid onset of annular circinate lesions with micro-pustules at the borders without classic plaque psoriasis manifestations. Most reported cases have been described in childhood with a relative benign course, fast and long-term remission after treatment. However, the recalcitrant course may result in an important negative impact on patients’ quality of life. Many systemic treatments have been reported for the management of moderate to severe forms, with variable clinical outcomes. However, data about the use of biologics in this rare psoriasis subtype are still lacking. Herein, we report the first case of circinate psoriasis unresponsive to methotrexate and almost all classes of biologics approved for psoriasis (anti-tumour necrosis factor (TNF), anti-interleukin (IL)-12/23, and anti-IL-17) which was successfully treated with risankizumab (anti-IL-23).https://www.karger.com/Article/FullText/523756risankizumablapiere’s psoriasiscircinate psoriasis |
| spellingShingle | Angelo Ruggiero Wanda Lauro Gabriella Fabbrocini Chiara Miano Alessia Villani Claudio Marasca A Case of Recalcitrant Circinate Generalized (Lapière) Psoriasis Successfully Treated with Risankizumab Case Reports in Dermatology risankizumab lapiere’s psoriasis circinate psoriasis |
| title | A Case of Recalcitrant Circinate Generalized (Lapière) Psoriasis Successfully Treated with Risankizumab |
| title_full | A Case of Recalcitrant Circinate Generalized (Lapière) Psoriasis Successfully Treated with Risankizumab |
| title_fullStr | A Case of Recalcitrant Circinate Generalized (Lapière) Psoriasis Successfully Treated with Risankizumab |
| title_full_unstemmed | A Case of Recalcitrant Circinate Generalized (Lapière) Psoriasis Successfully Treated with Risankizumab |
| title_short | A Case of Recalcitrant Circinate Generalized (Lapière) Psoriasis Successfully Treated with Risankizumab |
| title_sort | case of recalcitrant circinate generalized lapiere psoriasis successfully treated with risankizumab |
| topic | risankizumab lapiere’s psoriasis circinate psoriasis |
| url | https://www.karger.com/Article/FullText/523756 |
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