PCSK9-mediated degradation of the LDL receptor generates a 17 kDa C-terminal LDL receptor fragment

PCSK9-mediated degradation of the LDL receptor generates a 17 kDa C-terminal LDL receptor fragment

Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to the LDL receptor (LDLR) at the cell surface and reroutes the internalized LDLR to intracellular degradation. In this study, we have shown that PCSK9-mediated degradation of the full-length 160 kDa LDLR generates a 17 kDa C-terminal LDLR...

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Bibliographic Details
Main Authors: Kristian Tveten, Thea Bismo Str⊘m, Knut Erik Berge, Trond P. Leren
Format: Article
Language:English
Published: Elsevier 2013-06-01
Series:Journal of Lipid Research
Subjects:
cathepsin
cleavage
degradation
endosome
low density lipoprotein
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520357126

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