Indoleamine-2,3-Dioxygenase Mediates Emotional Deficits by the Kynurenine/Tryptophan Pathway in the Ethanol Addiction/Withdrawal Mouse Model

Indoleamine-2,3-Dioxygenase Mediates Emotional Deficits by the Kynurenine/Tryptophan Pathway in the Ethanol Addiction/Withdrawal Mouse Model

ObjectiveOur study was designed to investigate whether the indoleamine-2,3-dioxygenase (IDO)-mediated kynurenine/tryptophan (KYN/TRP) pathway participates in the development of emotional deficits from ethanol addiction/withdrawal mice.MethodsThe expression of proinflammatory factors, including tumor...

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Bibliographic Details
Main Authors: Xi Jiang, Qian Lin, Lexing Xu, Ziwei Chen, Qizhi Yan, Lei Chen, Xuefeng Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
ethanol addiction
indoleamine 2
3-dioxygenase
depression
anxiety
memory
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.00011/full

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