Different mechanisms contributing to savings and anterograde interference are impaired in Parkinson’s disease
Reinforcement and use-dependent plasticity mechanisms have been proposed to be involved in both savings and anterograde interference in adaptation to a visuomotor rotation (c.f.Huang et al., 2011). In Parkinson’s disease (PD), dopamine dysfunction is known to impair reinforcement mechanisms, and cou...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-02-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnhum.2013.00055/full |
| _version_ | 1818519089147019264 |
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| author | Li-Ann eLeow Li-Ann eLeow Aymar ede Rugy Andrea Mary Loftus Andrea Mary Loftus Geoff eHammond |
| author_facet | Li-Ann eLeow Li-Ann eLeow Aymar ede Rugy Andrea Mary Loftus Andrea Mary Loftus Geoff eHammond |
| author_sort | Li-Ann eLeow |
| collection | DOAJ |
| description | Reinforcement and use-dependent plasticity mechanisms have been proposed to be involved in both savings and anterograde interference in adaptation to a visuomotor rotation (c.f.Huang et al., 2011). In Parkinson’s disease (PD), dopamine dysfunction is known to impair reinforcement mechanisms, and could also affect use-dependent plasticity. Here, we assessed savings and anterograde interference in PD with an A1-B-A2 paradigm in which movement repetition was (i) favored by the use of a single target, and (ii) manipulated through the amount of initial training. PD patients and controls completed either limited or extended training in A1 where they adapted movement to a 30° counter-clockwise rotation of visual feedback of the movement trajectory, and then adapted to a 30° clockwise rotation in B. After subsequent washout, participants readapted to the first 30° counter-clockwise rotation in A2. Controls showed significant anterograde interference from A1 to B only after extended training, and significant A1-B-A2 savings after both limited and extended training. However, despite similar A1 adaptation to controls, PD patients showed neither anterograde interference nor savings. That extended training was necessary in controls to elicit anterograde interference but not savings suggests that savings and anterograde interference do not result from equal contributions of the same underlying mechanism(s). It is suggested that use-dependent plasticity mechanisms contributes to anterograde interference but not to savings, while reinforcement mechanisms contribute to both. As both savings and anterograde interference were impaired in PD, dopamine dysfunction in PD might impair both reinforcement and use-dependent plasticity mechanisms during adaptation to a visuomotor rotation. |
| first_indexed | 2024-12-11T01:18:59Z |
| format | Article |
| id | doaj.art-cc6576bc5c1d432f98bfdcab57120291 |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-11T01:18:59Z |
| publishDate | 2013-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-cc6576bc5c1d432f98bfdcab571202912022-12-22T01:25:47ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612013-02-01710.3389/fnhum.2013.0005539031Different mechanisms contributing to savings and anterograde interference are impaired in Parkinson’s diseaseLi-Ann eLeow0Li-Ann eLeow1Aymar ede Rugy2Andrea Mary Loftus3Andrea Mary Loftus4Geoff eHammond5School of Psychology, University of Western AustraliaParkinson's Centre (ParkC), Edith Cowan UniversityThe University of QueenslandParkinson's Centre (ParkC), Edith Cowan UniversitySchool of Psychology and Speech Pathology, Curtin UniversitySchool of Psychology, University of Western AustraliaReinforcement and use-dependent plasticity mechanisms have been proposed to be involved in both savings and anterograde interference in adaptation to a visuomotor rotation (c.f.Huang et al., 2011). In Parkinson’s disease (PD), dopamine dysfunction is known to impair reinforcement mechanisms, and could also affect use-dependent plasticity. Here, we assessed savings and anterograde interference in PD with an A1-B-A2 paradigm in which movement repetition was (i) favored by the use of a single target, and (ii) manipulated through the amount of initial training. PD patients and controls completed either limited or extended training in A1 where they adapted movement to a 30° counter-clockwise rotation of visual feedback of the movement trajectory, and then adapted to a 30° clockwise rotation in B. After subsequent washout, participants readapted to the first 30° counter-clockwise rotation in A2. Controls showed significant anterograde interference from A1 to B only after extended training, and significant A1-B-A2 savings after both limited and extended training. However, despite similar A1 adaptation to controls, PD patients showed neither anterograde interference nor savings. That extended training was necessary in controls to elicit anterograde interference but not savings suggests that savings and anterograde interference do not result from equal contributions of the same underlying mechanism(s). It is suggested that use-dependent plasticity mechanisms contributes to anterograde interference but not to savings, while reinforcement mechanisms contribute to both. As both savings and anterograde interference were impaired in PD, dopamine dysfunction in PD might impair both reinforcement and use-dependent plasticity mechanisms during adaptation to a visuomotor rotation.http://journal.frontiersin.org/Journal/10.3389/fnhum.2013.00055/fullParkinson's diseasemotor learningmotor adaptationvisuomotor rotationanterograde interferencesavings |
| spellingShingle | Li-Ann eLeow Li-Ann eLeow Aymar ede Rugy Andrea Mary Loftus Andrea Mary Loftus Geoff eHammond Different mechanisms contributing to savings and anterograde interference are impaired in Parkinson’s disease Frontiers in Human Neuroscience Parkinson's disease motor learning motor adaptation visuomotor rotation anterograde interference savings |
| title | Different mechanisms contributing to savings and anterograde interference are impaired in Parkinson’s disease |
| title_full | Different mechanisms contributing to savings and anterograde interference are impaired in Parkinson’s disease |
| title_fullStr | Different mechanisms contributing to savings and anterograde interference are impaired in Parkinson’s disease |
| title_full_unstemmed | Different mechanisms contributing to savings and anterograde interference are impaired in Parkinson’s disease |
| title_short | Different mechanisms contributing to savings and anterograde interference are impaired in Parkinson’s disease |
| title_sort | different mechanisms contributing to savings and anterograde interference are impaired in parkinson s disease |
| topic | Parkinson's disease motor learning motor adaptation visuomotor rotation anterograde interference savings |
| url | http://journal.frontiersin.org/Journal/10.3389/fnhum.2013.00055/full |
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