Reactive pericytes in early phase are involved in glial activation and late-onset hypersusceptibility to pilocarpine-induced seizures in traumatic brain injury model mice

Reactive pericytes in early phase are involved in glial activation and late-onset hypersusceptibility to pilocarpine-induced seizures in traumatic brain injury model mice

In this study, among neurovascular unit (NVU) cells, we focused on pericyte reactivity in mice subjected to controlled cortical impact (CCI) to understand how traumatic brain injury (TBI) causes uncoordinated crosstalk in the NVU and alters neuronal activity. Histological analyses of brain pericytes...

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Bibliographic Details
Main Authors: Kenta Sakai, Fuyuko Takata, Gaku Yamanaka, Miho Yasunaga, Kana Hashiguchi, Kazuki Tominaga, Kouichi Itoh, Yasufumi Kataoka, Atsushi Yamauchi, Shinya Dohgu
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Journal of Pharmacological Sciences
Subjects:
Traumatic brain injury
Reactive pericytes
PDGFRβ
Imatinib
Microglia
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861320301146

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