The chemokine receptor CCR5: multi-faceted hook for HIV-1
Abstract Chemokines are cytokines whose primary role is cellular activation and stimulation of leukocyte migration. They perform their various functions by interacting with G protein-coupled cell surface receptors (GPCRs) and are involved in the regulation of many biological processes such as apopto...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | Retrovirology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12977-024-00634-1 |
| _version_ | 1797276359056162816 |
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| author | Natacha Faivre Christel Verollet Fabrice Dumas |
| author_facet | Natacha Faivre Christel Verollet Fabrice Dumas |
| author_sort | Natacha Faivre |
| collection | DOAJ |
| description | Abstract Chemokines are cytokines whose primary role is cellular activation and stimulation of leukocyte migration. They perform their various functions by interacting with G protein-coupled cell surface receptors (GPCRs) and are involved in the regulation of many biological processes such as apoptosis, proliferation, angiogenesis, hematopoiesis or organogenesis. They contribute to the maintenance of the homeostasis of lymphocytes and coordinate the function of the immune system. However, chemokines and their receptors are sometimes hijacked by some pathogens to infect the host organism. For a given chemokine receptor, there is a wide structural, organizational and conformational diversity. In this review, we describe the evidence for structural variety reported for the chemokine receptor CCR5, how this variability can be exploited by HIV-1 to infect its target cells and what therapeutic solutions are currently being developed to overcome this problem. |
| first_indexed | 2024-03-07T15:27:09Z |
| format | Article |
| id | doaj.art-cc66ea46263b49509fc53ed2196c0384 |
| institution | Directory Open Access Journal |
| issn | 1742-4690 |
| language | English |
| last_indexed | 2024-03-07T15:27:09Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Retrovirology |
| spelling | doaj.art-cc66ea46263b49509fc53ed2196c03842024-03-05T16:41:02ZengBMCRetrovirology1742-46902024-01-0121111410.1186/s12977-024-00634-1The chemokine receptor CCR5: multi-faceted hook for HIV-1Natacha Faivre0Christel Verollet1Fabrice Dumas2Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III – Paul Sabatier (UPS)Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III – Paul Sabatier (UPS)Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III – Paul Sabatier (UPS)Abstract Chemokines are cytokines whose primary role is cellular activation and stimulation of leukocyte migration. They perform their various functions by interacting with G protein-coupled cell surface receptors (GPCRs) and are involved in the regulation of many biological processes such as apoptosis, proliferation, angiogenesis, hematopoiesis or organogenesis. They contribute to the maintenance of the homeostasis of lymphocytes and coordinate the function of the immune system. However, chemokines and their receptors are sometimes hijacked by some pathogens to infect the host organism. For a given chemokine receptor, there is a wide structural, organizational and conformational diversity. In this review, we describe the evidence for structural variety reported for the chemokine receptor CCR5, how this variability can be exploited by HIV-1 to infect its target cells and what therapeutic solutions are currently being developed to overcome this problem.https://doi.org/10.1186/s12977-024-00634-1HIV-1CCR5Chemokine receptorConformationLipid membrane |
| spellingShingle | Natacha Faivre Christel Verollet Fabrice Dumas The chemokine receptor CCR5: multi-faceted hook for HIV-1 Retrovirology HIV-1 CCR5 Chemokine receptor Conformation Lipid membrane |
| title | The chemokine receptor CCR5: multi-faceted hook for HIV-1 |
| title_full | The chemokine receptor CCR5: multi-faceted hook for HIV-1 |
| title_fullStr | The chemokine receptor CCR5: multi-faceted hook for HIV-1 |
| title_full_unstemmed | The chemokine receptor CCR5: multi-faceted hook for HIV-1 |
| title_short | The chemokine receptor CCR5: multi-faceted hook for HIV-1 |
| title_sort | chemokine receptor ccr5 multi faceted hook for hiv 1 |
| topic | HIV-1 CCR5 Chemokine receptor Conformation Lipid membrane |
| url | https://doi.org/10.1186/s12977-024-00634-1 |
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