Targeting Apoptotic Pathway of Cancer Cells with Phytochemicals and Plant-Based Nanomaterials
Apoptosis is the elimination of functionally non-essential, neoplastic, and infected cells via the mitochondrial pathway or death receptor pathway. The process of apoptosis is highly regulated through membrane channels and apoptogenic proteins. Apoptosis maintains cellular balance within the human b...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/13/2/194 |
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| author | Atif Khurshid Wani Nahid Akhtar Tahir ul Gani Mir Rattandeep Singh Prakash Kumar Jha Shyam Kumar Mallik Shruti Sinha Surya Kant Tripathi Abha Jain Aprajita Jha Hari Prasad Devkota Ajit Prakash |
| author_facet | Atif Khurshid Wani Nahid Akhtar Tahir ul Gani Mir Rattandeep Singh Prakash Kumar Jha Shyam Kumar Mallik Shruti Sinha Surya Kant Tripathi Abha Jain Aprajita Jha Hari Prasad Devkota Ajit Prakash |
| author_sort | Atif Khurshid Wani |
| collection | DOAJ |
| description | Apoptosis is the elimination of functionally non-essential, neoplastic, and infected cells via the mitochondrial pathway or death receptor pathway. The process of apoptosis is highly regulated through membrane channels and apoptogenic proteins. Apoptosis maintains cellular balance within the human body through cell cycle progression. Loss of apoptosis control prolongs cancer cell survival and allows the accumulation of mutations that can promote angiogenesis, promote cell proliferation, disrupt differentiation, and increase invasiveness during tumor progression. The apoptotic pathway has been extensively studied as a potential drug target in cancer treatment. However, the off-target activities of drugs and negative implications have been a matter of concern over the years. Phytochemicals (PCs) have been studied for their efficacy in various cancer cell lines individually and synergistically. The development of nanoparticles (NPs) through green synthesis has added a new dimension to the advancement of plant-based nanomaterials for effective cancer treatment. This review provides a detailed insight into the fundamental molecular pathways of programmed cell death and highlights the role of PCs along with the existing drugs and plant-based NPs in treating cancer by targeting its programmed cell death (PCD) network. |
| first_indexed | 2024-03-11T09:06:19Z |
| format | Article |
| id | doaj.art-cc670df7da994827b0376d8aaa2312bd |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-11T09:06:19Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-cc670df7da994827b0376d8aaa2312bd2023-11-16T19:21:41ZengMDPI AGBiomolecules2218-273X2023-01-0113219410.3390/biom13020194Targeting Apoptotic Pathway of Cancer Cells with Phytochemicals and Plant-Based NanomaterialsAtif Khurshid Wani0Nahid Akhtar1Tahir ul Gani Mir2Rattandeep Singh3Prakash Kumar Jha4Shyam Kumar Mallik5Shruti Sinha6Surya Kant Tripathi7Abha Jain8Aprajita Jha9Hari Prasad Devkota10Ajit Prakash11School of Bioengineering and Biosciences, Lovely Professional University, Phagwara 144411, IndiaSchool of Bioengineering and Biosciences, Lovely Professional University, Phagwara 144411, IndiaSchool of Bioengineering and Biosciences, Lovely Professional University, Phagwara 144411, IndiaSchool of Bioengineering and Biosciences, Lovely Professional University, Phagwara 144411, IndiaFeed the Future Innovation Lab for Collaborative Research on Sustainable Intensification, Kansas State University, Manhattan, KS 66506, USACollege of Medical and Allied Sciences, Purbanchal University, Morang 56600, NepalUNC Blood Research Center, University of North Carolina, Chapel Hill, NC 27599, USALineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USADivision of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USASchool of Biotechnology, Kalinga Institute of Industrial Technology, Bhubaneswar 751024, IndiaGraduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, JapanDepartment of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USAApoptosis is the elimination of functionally non-essential, neoplastic, and infected cells via the mitochondrial pathway or death receptor pathway. The process of apoptosis is highly regulated through membrane channels and apoptogenic proteins. Apoptosis maintains cellular balance within the human body through cell cycle progression. Loss of apoptosis control prolongs cancer cell survival and allows the accumulation of mutations that can promote angiogenesis, promote cell proliferation, disrupt differentiation, and increase invasiveness during tumor progression. The apoptotic pathway has been extensively studied as a potential drug target in cancer treatment. However, the off-target activities of drugs and negative implications have been a matter of concern over the years. Phytochemicals (PCs) have been studied for their efficacy in various cancer cell lines individually and synergistically. The development of nanoparticles (NPs) through green synthesis has added a new dimension to the advancement of plant-based nanomaterials for effective cancer treatment. This review provides a detailed insight into the fundamental molecular pathways of programmed cell death and highlights the role of PCs along with the existing drugs and plant-based NPs in treating cancer by targeting its programmed cell death (PCD) network.https://www.mdpi.com/2218-273X/13/2/194cancerapoptosisdrugsphytochemicalsinhibitorsnanomaterials |
| spellingShingle | Atif Khurshid Wani Nahid Akhtar Tahir ul Gani Mir Rattandeep Singh Prakash Kumar Jha Shyam Kumar Mallik Shruti Sinha Surya Kant Tripathi Abha Jain Aprajita Jha Hari Prasad Devkota Ajit Prakash Targeting Apoptotic Pathway of Cancer Cells with Phytochemicals and Plant-Based Nanomaterials Biomolecules cancer apoptosis drugs phytochemicals inhibitors nanomaterials |
| title | Targeting Apoptotic Pathway of Cancer Cells with Phytochemicals and Plant-Based Nanomaterials |
| title_full | Targeting Apoptotic Pathway of Cancer Cells with Phytochemicals and Plant-Based Nanomaterials |
| title_fullStr | Targeting Apoptotic Pathway of Cancer Cells with Phytochemicals and Plant-Based Nanomaterials |
| title_full_unstemmed | Targeting Apoptotic Pathway of Cancer Cells with Phytochemicals and Plant-Based Nanomaterials |
| title_short | Targeting Apoptotic Pathway of Cancer Cells with Phytochemicals and Plant-Based Nanomaterials |
| title_sort | targeting apoptotic pathway of cancer cells with phytochemicals and plant based nanomaterials |
| topic | cancer apoptosis drugs phytochemicals inhibitors nanomaterials |
| url | https://www.mdpi.com/2218-273X/13/2/194 |
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