Running Loose or Getting Lost: How HIV-1 Counters and Capitalizes on APOBEC3-Induced Mutagenesis through Its Vif Protein
Human immunodeficiency virus-1 (HIV-1) dynamics reflect an intricate balance within the viruses’ host. The virus relies on host replication factors, but must escape or counter its host’s antiviral restriction factors. The interaction between the HIV-1 protein Vif and many...
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| Format: | Article |
| Language: | English |
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MDPI AG
2012-11-01
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| Series: | Viruses |
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| Online Access: | http://www.mdpi.com/1999-4915/4/11/3132 |
| _version_ | 1818308681885810688 |
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| author | Christel Kamp Dieter Häussinger Jörg Zielonka Carsten Münk Björn-Erik O. Jensen |
| author_facet | Christel Kamp Dieter Häussinger Jörg Zielonka Carsten Münk Björn-Erik O. Jensen |
| author_sort | Christel Kamp |
| collection | DOAJ |
| description | Human immunodeficiency virus-1 (HIV-1) dynamics reflect an intricate balance within the viruses’ host. The virus relies on host replication factors, but must escape or counter its host’s antiviral restriction factors. The interaction between the HIV-1 protein Vif and many cellular restriction factors from the APOBEC3 protein family is a prominent example of this evolutionary arms race. The viral infectivity factor (Vif) protein largely neutralizes APOBEC3 proteins, which can induce in vivo hypermutations in HIV-1 to the extent of lethal mutagenesis, and ensures the production of viable virus particles. HIV-1 also uses the APOBEC3-Vif interaction to modulate its own mutation rate in harsh or variable environments, and it is a model of adaptation in a coevolutionary setting. Both experimental evidence and the substantiation of the underlying dynamics through coevolutionary models are presented as complementary views of a coevolutionary arms race. |
| first_indexed | 2024-12-13T07:18:09Z |
| format | Article |
| id | doaj.art-cc67bc27af924041b0c24dbb1f5fa5e7 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-13T07:18:09Z |
| publishDate | 2012-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-cc67bc27af924041b0c24dbb1f5fa5e72022-12-21T23:55:30ZengMDPI AGViruses1999-49152012-11-014113132316110.3390/v4113132Running Loose or Getting Lost: How HIV-1 Counters and Capitalizes on APOBEC3-Induced Mutagenesis through Its Vif ProteinChristel KampDieter HäussingerJörg ZielonkaCarsten MünkBjörn-Erik O. JensenHuman immunodeficiency virus-1 (HIV-1) dynamics reflect an intricate balance within the viruses’ host. The virus relies on host replication factors, but must escape or counter its host’s antiviral restriction factors. The interaction between the HIV-1 protein Vif and many cellular restriction factors from the APOBEC3 protein family is a prominent example of this evolutionary arms race. The viral infectivity factor (Vif) protein largely neutralizes APOBEC3 proteins, which can induce in vivo hypermutations in HIV-1 to the extent of lethal mutagenesis, and ensures the production of viable virus particles. HIV-1 also uses the APOBEC3-Vif interaction to modulate its own mutation rate in harsh or variable environments, and it is a model of adaptation in a coevolutionary setting. Both experimental evidence and the substantiation of the underlying dynamics through coevolutionary models are presented as complementary views of a coevolutionary arms race.http://www.mdpi.com/1999-4915/4/11/3132HIV-1APOBEC3Vifcoevolutionquasispeciespopulation geneticsmodelingdrug resistanceescape mutant |
| spellingShingle | Christel Kamp Dieter Häussinger Jörg Zielonka Carsten Münk Björn-Erik O. Jensen Running Loose or Getting Lost: How HIV-1 Counters and Capitalizes on APOBEC3-Induced Mutagenesis through Its Vif Protein Viruses HIV-1 APOBEC3 Vif coevolution quasispecies population genetics modeling drug resistance escape mutant |
| title | Running Loose or Getting Lost: How HIV-1 Counters and Capitalizes on APOBEC3-Induced Mutagenesis through Its Vif Protein |
| title_full | Running Loose or Getting Lost: How HIV-1 Counters and Capitalizes on APOBEC3-Induced Mutagenesis through Its Vif Protein |
| title_fullStr | Running Loose or Getting Lost: How HIV-1 Counters and Capitalizes on APOBEC3-Induced Mutagenesis through Its Vif Protein |
| title_full_unstemmed | Running Loose or Getting Lost: How HIV-1 Counters and Capitalizes on APOBEC3-Induced Mutagenesis through Its Vif Protein |
| title_short | Running Loose or Getting Lost: How HIV-1 Counters and Capitalizes on APOBEC3-Induced Mutagenesis through Its Vif Protein |
| title_sort | running loose or getting lost how hiv 1 counters and capitalizes on apobec3 induced mutagenesis through its vif protein |
| topic | HIV-1 APOBEC3 Vif coevolution quasispecies population genetics modeling drug resistance escape mutant |
| url | http://www.mdpi.com/1999-4915/4/11/3132 |
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