Running Loose or Getting Lost: How HIV-1 Counters and Capitalizes on APOBEC3-Induced Mutagenesis through Its Vif Protein

Running Loose or Getting Lost: How HIV-1 Counters and Capitalizes on APOBEC3-Induced Mutagenesis through Its Vif Protein

Human immunodeficiency virus-1 (HIV-1) dynamics reflect an intricate balance within the viruses’ host. The virus relies on host replication factors, but must escape or counter its host’s antiviral restriction factors. The interaction between the HIV-1 protein Vif and many...

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Bibliographic Details
Main Authors: Christel Kamp, Dieter Häussinger, Jörg Zielonka, Carsten Münk, Björn-Erik O. Jensen
Format: Article
Language:English
Published: MDPI AG 2012-11-01
Series:Viruses
Subjects:
HIV-1
APOBEC3
Vif
coevolution
quasispecies
population genetics
modeling
drug resistance
escape mutant
Online Access:http://www.mdpi.com/1999-4915/4/11/3132

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