Choroid plexus volume enlargement in first-episode antipsychotic-naïve schizophrenia
Abstract Investigation of the choroid plexus in schizophrenia has seen growing interest due to its role in the interaction between neuroinflammation and brain dysfunction. Most previous studies included treated and long-term ill patients, while antipsychotics and illness course might both affect the...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-01-01
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| Series: | Schizophrenia |
| Online Access: | https://doi.org/10.1038/s41537-023-00424-2 |
| _version_ | 1797363193910132736 |
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| author | Jiaxin Zeng Tianwei Zhang Biqiu Tang Siyi Li Li Yao Jeffrey R. Bishop John A. Sweeney Zhenlin Li Changjian Qiu Shi Gu Qiyong Gong Wenjing Zhang Su Lui |
| author_facet | Jiaxin Zeng Tianwei Zhang Biqiu Tang Siyi Li Li Yao Jeffrey R. Bishop John A. Sweeney Zhenlin Li Changjian Qiu Shi Gu Qiyong Gong Wenjing Zhang Su Lui |
| author_sort | Jiaxin Zeng |
| collection | DOAJ |
| description | Abstract Investigation of the choroid plexus in schizophrenia has seen growing interest due to its role in the interaction between neuroinflammation and brain dysfunction. Most previous studies included treated and long-term ill patients, while antipsychotics and illness course might both affect the choroid plexus. Here, we recruited first-episode antipsychotic-naïve schizophrenia patients, performed high-resolution structural brain scan and manually extracted choroid plexus volume. Choroid plexus volume was compared between patients and healthy controls after controlling for age, sex and intracranial volume. Age and sex effects were examined on choroid plexus volume in patient and healthy control groups respectively. In patients, we also examined the correlation of choroid plexus volume with volume measures of cortical and subcortical gray matter, white matter, lateral ventricular as well as symptom severity and cognitive function. Schizophrenia patients showed significantly enlarged choroid plexus volume compared with healthy controls. Choroid plexus volume was positively correlated with age in only patient group and we found significantly larger choroid plexus volumes in males than females in both patient and healthy control groups, while the sex effects did not differ between groups. Choroid plexus volume was only found correlated with lateral ventricular volume among the brain volume measures. No significant correlation between choroid plexus volume and clinical ratings or cognitive performance was observed. Without potential confounding effects of pharmacotherapy or illness course, our findings indicated the enlargement of choroid plexus in schizophrenia might be an enduring trait for schizophrenia. |
| first_indexed | 2024-03-08T16:17:41Z |
| format | Article |
| id | doaj.art-cc6a7d1261ae425ebb88bea058a37a61 |
| institution | Directory Open Access Journal |
| issn | 2754-6993 |
| language | English |
| last_indexed | 2024-03-08T16:17:41Z |
| publishDate | 2024-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Schizophrenia |
| spelling | doaj.art-cc6a7d1261ae425ebb88bea058a37a612024-01-07T12:30:46ZengNature PortfolioSchizophrenia2754-69932024-01-011011610.1038/s41537-023-00424-2Choroid plexus volume enlargement in first-episode antipsychotic-naïve schizophreniaJiaxin Zeng0Tianwei Zhang1Biqiu Tang2Siyi Li3Li Yao4Jeffrey R. Bishop5John A. Sweeney6Zhenlin Li7Changjian Qiu8Shi Gu9Qiyong Gong10Wenjing Zhang11Su Lui12Department of Radiology, and Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan UniversityHuaxi MR Research Center (HMRRC), West China Hospital of Sichuan UniversityDepartment of Radiology, and Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan UniversityDepartment of Radiology, and Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan UniversityDepartment of Radiology, and Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan UniversityDepartment of Experimental and Clinical Pharmacology, College of Pharmacy, University of MinnesotaHuaxi MR Research Center (HMRRC), West China Hospital of Sichuan UniversityDepartment of Radiology, and Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan UniversityMental Health Center, West China Hospital of Sichuan UniversitySchool of Computer Science and Engineering, University of Electronic Science and Technology of ChinaDepartment of Radiology, and Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan UniversityDepartment of Radiology, and Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan UniversityDepartment of Radiology, and Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan UniversityAbstract Investigation of the choroid plexus in schizophrenia has seen growing interest due to its role in the interaction between neuroinflammation and brain dysfunction. Most previous studies included treated and long-term ill patients, while antipsychotics and illness course might both affect the choroid plexus. Here, we recruited first-episode antipsychotic-naïve schizophrenia patients, performed high-resolution structural brain scan and manually extracted choroid plexus volume. Choroid plexus volume was compared between patients and healthy controls after controlling for age, sex and intracranial volume. Age and sex effects were examined on choroid plexus volume in patient and healthy control groups respectively. In patients, we also examined the correlation of choroid plexus volume with volume measures of cortical and subcortical gray matter, white matter, lateral ventricular as well as symptom severity and cognitive function. Schizophrenia patients showed significantly enlarged choroid plexus volume compared with healthy controls. Choroid plexus volume was positively correlated with age in only patient group and we found significantly larger choroid plexus volumes in males than females in both patient and healthy control groups, while the sex effects did not differ between groups. Choroid plexus volume was only found correlated with lateral ventricular volume among the brain volume measures. No significant correlation between choroid plexus volume and clinical ratings or cognitive performance was observed. Without potential confounding effects of pharmacotherapy or illness course, our findings indicated the enlargement of choroid plexus in schizophrenia might be an enduring trait for schizophrenia.https://doi.org/10.1038/s41537-023-00424-2 |
| spellingShingle | Jiaxin Zeng Tianwei Zhang Biqiu Tang Siyi Li Li Yao Jeffrey R. Bishop John A. Sweeney Zhenlin Li Changjian Qiu Shi Gu Qiyong Gong Wenjing Zhang Su Lui Choroid plexus volume enlargement in first-episode antipsychotic-naïve schizophrenia Schizophrenia |
| title | Choroid plexus volume enlargement in first-episode antipsychotic-naïve schizophrenia |
| title_full | Choroid plexus volume enlargement in first-episode antipsychotic-naïve schizophrenia |
| title_fullStr | Choroid plexus volume enlargement in first-episode antipsychotic-naïve schizophrenia |
| title_full_unstemmed | Choroid plexus volume enlargement in first-episode antipsychotic-naïve schizophrenia |
| title_short | Choroid plexus volume enlargement in first-episode antipsychotic-naïve schizophrenia |
| title_sort | choroid plexus volume enlargement in first episode antipsychotic naive schizophrenia |
| url | https://doi.org/10.1038/s41537-023-00424-2 |
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