Role of 3D quantitative tumor analysis for predicting overall survival after conventional chemoembolization of intrahepatic cholangiocarcinoma
Abstract This study was designed to assess 3D vs. 1D and 2D quantitative tumor analysis for prediction of overall survival (OS) in patients with Intrahepatic Cholangiocarcinoma (ICC) who underwent conventional transarterial chemoembolization (cTACE). 73 ICC patients who underwent cTACE were included...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-88426-x |
| _version_ | 1818433261092732928 |
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| author | Irvin Rexha Fabian Laage-Gaupp Julius Chapiro Milena Anna Miszczuk Johanna Maria Mijntje van Breugel MingDe Lin Menelaos Konstantinidis Rafael Duran Bernhard Gebauer Christos Georgiades Kelvin Hong Nariman Nezami |
| author_facet | Irvin Rexha Fabian Laage-Gaupp Julius Chapiro Milena Anna Miszczuk Johanna Maria Mijntje van Breugel MingDe Lin Menelaos Konstantinidis Rafael Duran Bernhard Gebauer Christos Georgiades Kelvin Hong Nariman Nezami |
| author_sort | Irvin Rexha |
| collection | DOAJ |
| description | Abstract This study was designed to assess 3D vs. 1D and 2D quantitative tumor analysis for prediction of overall survival (OS) in patients with Intrahepatic Cholangiocarcinoma (ICC) who underwent conventional transarterial chemoembolization (cTACE). 73 ICC patients who underwent cTACE were included in this retrospective analysis between Oct 2001 and Feb 2015. The overall and enhancing tumor diameters and the maximum cross-sectional and enhancing tumor areas were measured on baseline images. 3D quantitative tumor analysis was used to assess total tumor volume (TTV), enhancing tumor volume (ETV), and enhancing tumor burden (ETB) (ratio between ETV and liver volume). Patients were divided into low (LTB) and high tumor burden (HTB) groups. There was a significant separation between survival curves of the LTB and HTB groups using enhancing tumor diameter (p = 0.003), enhancing tumor area (p = 0.03), TTV (p = 0.03), and ETV (p = 0.01). Multivariate analysis showed a hazard ratio of 0.46 (95%CI: 0.27–0.78, p = 0.004) for enhancing tumor diameter, 0.56 (95% CI 0.33–0.96, p = 0.04) for enhancing tumor area, 0.58 (95%CI: 0.34–0.98, p = 0.04) for TTV, and 0.52 (95%CI: 0.30–0.91, p = 0.02) for ETV. TTV and ETV, as well as the largest enhancing tumor diameter and maximum enhancing tumor area, reliably predict the OS of patients with ICC after cTACE and could identify ICC patients who are most likely to benefit from cTACE. |
| first_indexed | 2024-12-14T16:18:17Z |
| format | Article |
| id | doaj.art-cc6d0d3c30ec4a84b352388775280341 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T16:18:17Z |
| publishDate | 2021-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-cc6d0d3c30ec4a84b3523887752803412022-12-21T22:54:52ZengNature PortfolioScientific Reports2045-23222021-04-0111111210.1038/s41598-021-88426-xRole of 3D quantitative tumor analysis for predicting overall survival after conventional chemoembolization of intrahepatic cholangiocarcinomaIrvin Rexha0Fabian Laage-Gaupp1Julius Chapiro2Milena Anna Miszczuk3Johanna Maria Mijntje van Breugel4MingDe Lin5Menelaos Konstantinidis6Rafael Duran7Bernhard Gebauer8Christos Georgiades9Kelvin Hong10Nariman Nezami11Department of Radiology and Biomedical Imaging, Yale University School of MedicineDepartment of Radiology and Biomedical Imaging, Yale University School of MedicineDepartment of Radiology and Biomedical Imaging, Yale University School of MedicineDepartment of Radiology and Biomedical Imaging, Yale University School of MedicineDepartment of Radiology and Biomedical Imaging, Yale University School of MedicineDepartment of Radiology and Biomedical Imaging, Yale University School of MedicineDivision of Biostatistics, Dalla Lana School of Public Health, University of TorontoDivision of Vascular and Interventional Radiology, Russel H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of MedicineDepartment of Diagnostic and Interventional Radiology, Charité UniversitätsmedizinDivision of Vascular and Interventional Radiology, Russel H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of MedicineDivision of Vascular and Interventional Radiology, Russel H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of MedicineDepartment of Radiology and Biomedical Imaging, Yale University School of MedicineAbstract This study was designed to assess 3D vs. 1D and 2D quantitative tumor analysis for prediction of overall survival (OS) in patients with Intrahepatic Cholangiocarcinoma (ICC) who underwent conventional transarterial chemoembolization (cTACE). 73 ICC patients who underwent cTACE were included in this retrospective analysis between Oct 2001 and Feb 2015. The overall and enhancing tumor diameters and the maximum cross-sectional and enhancing tumor areas were measured on baseline images. 3D quantitative tumor analysis was used to assess total tumor volume (TTV), enhancing tumor volume (ETV), and enhancing tumor burden (ETB) (ratio between ETV and liver volume). Patients were divided into low (LTB) and high tumor burden (HTB) groups. There was a significant separation between survival curves of the LTB and HTB groups using enhancing tumor diameter (p = 0.003), enhancing tumor area (p = 0.03), TTV (p = 0.03), and ETV (p = 0.01). Multivariate analysis showed a hazard ratio of 0.46 (95%CI: 0.27–0.78, p = 0.004) for enhancing tumor diameter, 0.56 (95% CI 0.33–0.96, p = 0.04) for enhancing tumor area, 0.58 (95%CI: 0.34–0.98, p = 0.04) for TTV, and 0.52 (95%CI: 0.30–0.91, p = 0.02) for ETV. TTV and ETV, as well as the largest enhancing tumor diameter and maximum enhancing tumor area, reliably predict the OS of patients with ICC after cTACE and could identify ICC patients who are most likely to benefit from cTACE.https://doi.org/10.1038/s41598-021-88426-x |
| spellingShingle | Irvin Rexha Fabian Laage-Gaupp Julius Chapiro Milena Anna Miszczuk Johanna Maria Mijntje van Breugel MingDe Lin Menelaos Konstantinidis Rafael Duran Bernhard Gebauer Christos Georgiades Kelvin Hong Nariman Nezami Role of 3D quantitative tumor analysis for predicting overall survival after conventional chemoembolization of intrahepatic cholangiocarcinoma Scientific Reports |
| title | Role of 3D quantitative tumor analysis for predicting overall survival after conventional chemoembolization of intrahepatic cholangiocarcinoma |
| title_full | Role of 3D quantitative tumor analysis for predicting overall survival after conventional chemoembolization of intrahepatic cholangiocarcinoma |
| title_fullStr | Role of 3D quantitative tumor analysis for predicting overall survival after conventional chemoembolization of intrahepatic cholangiocarcinoma |
| title_full_unstemmed | Role of 3D quantitative tumor analysis for predicting overall survival after conventional chemoembolization of intrahepatic cholangiocarcinoma |
| title_short | Role of 3D quantitative tumor analysis for predicting overall survival after conventional chemoembolization of intrahepatic cholangiocarcinoma |
| title_sort | role of 3d quantitative tumor analysis for predicting overall survival after conventional chemoembolization of intrahepatic cholangiocarcinoma |
| url | https://doi.org/10.1038/s41598-021-88426-x |
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