Mussel-inspired nanozyme catalyzed conductive and self-setting hydrogel for adhesive and antibacterial bioelectronics
Adhesive hydrogels have broad applications ranging from tissue engineering to bioelectronics; however, fabricating adhesive hydrogels with multiple functions remains a challenge. In this study, a mussel-inspired tannic acid chelated-Ag (TA-Ag) nanozyme with peroxidase (POD)-like activity was designe...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2021-09-01
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| Series: | Bioactive Materials |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X21000451 |
| _version_ | 1797205247596167168 |
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| author | Zhanrong Jia Xuanhan Lv Yue Hou Kefeng Wang Fuzeng Ren Dingguo Xu Qun Wang Kelong Fan Chaoming Xie Xiong Lu |
| author_facet | Zhanrong Jia Xuanhan Lv Yue Hou Kefeng Wang Fuzeng Ren Dingguo Xu Qun Wang Kelong Fan Chaoming Xie Xiong Lu |
| author_sort | Zhanrong Jia |
| collection | DOAJ |
| description | Adhesive hydrogels have broad applications ranging from tissue engineering to bioelectronics; however, fabricating adhesive hydrogels with multiple functions remains a challenge. In this study, a mussel-inspired tannic acid chelated-Ag (TA-Ag) nanozyme with peroxidase (POD)-like activity was designed by the in situ reduction of ultrasmall Ag nanoparticles (NPs) with TA. The ultrasmall TA-Ag nanozyme exhibited high catalytic activity to induce hydrogel self-setting without external aid. The nanozyme retained abundant phenolic hydroxyl groups and maintained the dynamic redox balance of phenol-quinone, providing the hydrogels with long-term and repeatable adhesiveness, similar to the adhesion of mussels. The phenolic hydroxyl groups also afforded uniform distribution of the nanozyme in the hydrogel network, thereby improving its mechanical properties and conductivity. Furthermore, the nanozyme endowed the hydrogel with antibacterial activity through synergistic effects of the reactive oxygen species generated via POD-like catalytic reactions and the intrinsic bactericidal activity of Ag. Owing to these advantages, the ultrasmall TA-Ag nanozyme-catalyzed hydrogel could be effectively used as an adhesive, antibacterial, and implantable bioelectrode to detect bio-signals, and as a wound dressing to accelerate tissue regeneration while preventing infection. Therefore, this study provides a promising approach for the fabrication of adhesive hydrogel bioelectronics with multiple functions via mussel-inspired nanozyme catalysis. |
| first_indexed | 2024-04-24T08:48:05Z |
| format | Article |
| id | doaj.art-cc6e002db5d046fcbc783b3568aeddc0 |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-04-24T08:48:05Z |
| publishDate | 2021-09-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-cc6e002db5d046fcbc783b3568aeddc02024-04-16T13:15:05ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2021-09-016926762687Mussel-inspired nanozyme catalyzed conductive and self-setting hydrogel for adhesive and antibacterial bioelectronicsZhanrong Jia0Xuanhan Lv1Yue Hou2Kefeng Wang3Fuzeng Ren4Dingguo Xu5Qun Wang6Kelong Fan7Chaoming Xie8Xiong Lu9Key Lab of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, Sichuan, ChinaKey Lab of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, Sichuan, ChinaKey Lab of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, Sichuan, ChinaNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610064, ChinaDepartment of Materials Science and Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, 518055, ChinaNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610064, ChinaCollege of Life Science and Biotechnology, Mianyang Teachers' College, Mianyang, 621006, ChinaCAS Engineering Laboratory for Nanozyme, Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China; Nanozyme Medical Center, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, 450001, ChinaKey Lab of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, Sichuan, China; Corresponding author.Key Lab of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, Sichuan, China; Corresponding author.Adhesive hydrogels have broad applications ranging from tissue engineering to bioelectronics; however, fabricating adhesive hydrogels with multiple functions remains a challenge. In this study, a mussel-inspired tannic acid chelated-Ag (TA-Ag) nanozyme with peroxidase (POD)-like activity was designed by the in situ reduction of ultrasmall Ag nanoparticles (NPs) with TA. The ultrasmall TA-Ag nanozyme exhibited high catalytic activity to induce hydrogel self-setting without external aid. The nanozyme retained abundant phenolic hydroxyl groups and maintained the dynamic redox balance of phenol-quinone, providing the hydrogels with long-term and repeatable adhesiveness, similar to the adhesion of mussels. The phenolic hydroxyl groups also afforded uniform distribution of the nanozyme in the hydrogel network, thereby improving its mechanical properties and conductivity. Furthermore, the nanozyme endowed the hydrogel with antibacterial activity through synergistic effects of the reactive oxygen species generated via POD-like catalytic reactions and the intrinsic bactericidal activity of Ag. Owing to these advantages, the ultrasmall TA-Ag nanozyme-catalyzed hydrogel could be effectively used as an adhesive, antibacterial, and implantable bioelectrode to detect bio-signals, and as a wound dressing to accelerate tissue regeneration while preventing infection. Therefore, this study provides a promising approach for the fabrication of adhesive hydrogel bioelectronics with multiple functions via mussel-inspired nanozyme catalysis.http://www.sciencedirect.com/science/article/pii/S2452199X21000451Mussel-inspired nanozymeAdhesive hydrogelConductive hydrogelAntibacterial hydrogelBioelectronics |
| spellingShingle | Zhanrong Jia Xuanhan Lv Yue Hou Kefeng Wang Fuzeng Ren Dingguo Xu Qun Wang Kelong Fan Chaoming Xie Xiong Lu Mussel-inspired nanozyme catalyzed conductive and self-setting hydrogel for adhesive and antibacterial bioelectronics Bioactive Materials Mussel-inspired nanozyme Adhesive hydrogel Conductive hydrogel Antibacterial hydrogel Bioelectronics |
| title | Mussel-inspired nanozyme catalyzed conductive and self-setting hydrogel for adhesive and antibacterial bioelectronics |
| title_full | Mussel-inspired nanozyme catalyzed conductive and self-setting hydrogel for adhesive and antibacterial bioelectronics |
| title_fullStr | Mussel-inspired nanozyme catalyzed conductive and self-setting hydrogel for adhesive and antibacterial bioelectronics |
| title_full_unstemmed | Mussel-inspired nanozyme catalyzed conductive and self-setting hydrogel for adhesive and antibacterial bioelectronics |
| title_short | Mussel-inspired nanozyme catalyzed conductive and self-setting hydrogel for adhesive and antibacterial bioelectronics |
| title_sort | mussel inspired nanozyme catalyzed conductive and self setting hydrogel for adhesive and antibacterial bioelectronics |
| topic | Mussel-inspired nanozyme Adhesive hydrogel Conductive hydrogel Antibacterial hydrogel Bioelectronics |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X21000451 |
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