Design and Validation of a Multiplex KIR and HLA Class I Genotyping Method Using Next Generation Sequencing

Design and Validation of a Multiplex KIR and HLA Class I Genotyping Method Using Next Generation Sequencing

Killer cell immunoglobulin-like receptors (KIR), considered the most polymorphic natural killer (NK) cell regulators, bind HLA class-I molecules or still unknown ligands. Interest in KIR genotyping is increasing because of the importance of these receptors for identifying the best possible donor in...

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Bibliographic Details
Main Authors: Laia Closa, Francisco Vidal, Maria J. Herrero, Jose L. Caro
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Immunology
Subjects:
KIR
HLA
next generation sequencing
genotyping
NGS analysis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02991/full

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