Comparison of Survival and Postoperative Complication of Stage Ⅰb2-Ⅱa2 Cervical Cancer Patients Among Three Kinds of Therapeutic Regimens
Objective To investigate the effects of radical surgery, neoadjuvant chemotherapy combined with radical surgery and concurrent chemoradiotherapy combined with radical surgery on the survival and postoperative complications of patients with stageⅠb2 andⅡa2 cervical cancer. Methods We retrospectively...
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| Format: | Article |
| Language: | zho |
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Magazine House of Cancer Research on Prevention and Treatment
2019-09-01
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| Series: | Zhongliu Fangzhi Yanjiu |
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| Online Access: | http://html.rhhz.net/ZLFZYJ/html/8578.2019.18.0605.htm |
| _version_ | 1811207760738516992 |
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| author | JIANG Hongqing LIU Ping LIU Zhihui |
| author_facet | JIANG Hongqing LIU Ping LIU Zhihui |
| author_sort | JIANG Hongqing |
| collection | DOAJ |
| description | Objective To investigate the effects of radical surgery, neoadjuvant chemotherapy combined with radical surgery and concurrent chemoradiotherapy combined with radical surgery on the survival and postoperative complications of patients with stageⅠb2 andⅡa2 cervical cancer. Methods We retrospectively analyzed the clinical data of 140 patients with stageⅠb2 and Ⅱa2 cervical cancer, 48 patients were treated with radical surgery alone (group A), 59 patients were treated with neoadjuvant chemotherapy combined with radical surgery (group B) and 33 patients were treated with concurrent chemoradiotherapy combined with radical surgery (group C). The intraoperative and postoperative clinical indicators, local invasion and lymph node metastasis rate, postoperative complication rate, median overall survival, and 1-, 2-, and 3-year survival rates were compared among three groups. Results There was no significant difference in the time of surgery and total hospital stay among the three groups (P > 0.05). The bleeding volume, postoperative vessel and muscle invasion rate and lymph node metastasis rate in group C were significantly lower than those in group A and B (P < 0.05). Postoperative neurological invasion rate, postoperative complication rate, median overall survival and postoperative 1-, 2- and 3-year survival rates showed no significant difference among three groups (P > 0.05). Group B was divided into radiotherapy group (n=28), chemotherapy group (n=13) and chemoradiotherapy group (n=18) according to preoperative treatment. The 3-year survival rate of radiotherapy group was significantly higher than those of chemotherapy group and radiotherapy group (P < 0.05). Conclusion The patients with stageⅠb2 andⅡa2 cervical cancer in three groups have similar survival condition and postoperative complications. However, concurrent chemoradiotherapy combined with radical surgery could reduce the surgical trauma, local postoperative invasion and lymph node metastasis rate. |
| first_indexed | 2024-04-12T04:10:05Z |
| format | Article |
| id | doaj.art-cc72343e064842bfa43696a2b60ed4a7 |
| institution | Directory Open Access Journal |
| issn | 1000-8578 1000-8578 |
| language | zho |
| last_indexed | 2024-04-12T04:10:05Z |
| publishDate | 2019-09-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj.art-cc72343e064842bfa43696a2b60ed4a72022-12-22T03:48:32ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85781000-85782019-09-0146982582810.3971/j.issn.1000-8578.2019.18.06058578.2019.18.0605Comparison of Survival and Postoperative Complication of Stage Ⅰb2-Ⅱa2 Cervical Cancer Patients Among Three Kinds of Therapeutic RegimensJIANG Hongqing0LIU Ping1LIU Zhihui2Department of Obstetrics and Gynecology, Second People's Hospital of Nanyang, Nanyang 473000, ChinaDepartment of Obstetrics and Gynecology, Second People's Hospital of Nanyang, Nanyang 473000, ChinaDepartment of Obstetrics and Gynecology, Second People's Hospital of Nanyang, Nanyang 473000, ChinaObjective To investigate the effects of radical surgery, neoadjuvant chemotherapy combined with radical surgery and concurrent chemoradiotherapy combined with radical surgery on the survival and postoperative complications of patients with stageⅠb2 andⅡa2 cervical cancer. Methods We retrospectively analyzed the clinical data of 140 patients with stageⅠb2 and Ⅱa2 cervical cancer, 48 patients were treated with radical surgery alone (group A), 59 patients were treated with neoadjuvant chemotherapy combined with radical surgery (group B) and 33 patients were treated with concurrent chemoradiotherapy combined with radical surgery (group C). The intraoperative and postoperative clinical indicators, local invasion and lymph node metastasis rate, postoperative complication rate, median overall survival, and 1-, 2-, and 3-year survival rates were compared among three groups. Results There was no significant difference in the time of surgery and total hospital stay among the three groups (P > 0.05). The bleeding volume, postoperative vessel and muscle invasion rate and lymph node metastasis rate in group C were significantly lower than those in group A and B (P < 0.05). Postoperative neurological invasion rate, postoperative complication rate, median overall survival and postoperative 1-, 2- and 3-year survival rates showed no significant difference among three groups (P > 0.05). Group B was divided into radiotherapy group (n=28), chemotherapy group (n=13) and chemoradiotherapy group (n=18) according to preoperative treatment. The 3-year survival rate of radiotherapy group was significantly higher than those of chemotherapy group and radiotherapy group (P < 0.05). Conclusion The patients with stageⅠb2 andⅡa2 cervical cancer in three groups have similar survival condition and postoperative complications. However, concurrent chemoradiotherapy combined with radical surgery could reduce the surgical trauma, local postoperative invasion and lymph node metastasis rate.http://html.rhhz.net/ZLFZYJ/html/8578.2019.18.0605.htmsurgeryneoadjuvant chemotherapyconcurrent chemoradiotherapycervical cancersurvival conditionpostoperative complication |
| spellingShingle | JIANG Hongqing LIU Ping LIU Zhihui Comparison of Survival and Postoperative Complication of Stage Ⅰb2-Ⅱa2 Cervical Cancer Patients Among Three Kinds of Therapeutic Regimens Zhongliu Fangzhi Yanjiu surgery neoadjuvant chemotherapy concurrent chemoradiotherapy cervical cancer survival condition postoperative complication |
| title | Comparison of Survival and Postoperative Complication of Stage Ⅰb2-Ⅱa2 Cervical Cancer Patients Among Three Kinds of Therapeutic Regimens |
| title_full | Comparison of Survival and Postoperative Complication of Stage Ⅰb2-Ⅱa2 Cervical Cancer Patients Among Three Kinds of Therapeutic Regimens |
| title_fullStr | Comparison of Survival and Postoperative Complication of Stage Ⅰb2-Ⅱa2 Cervical Cancer Patients Among Three Kinds of Therapeutic Regimens |
| title_full_unstemmed | Comparison of Survival and Postoperative Complication of Stage Ⅰb2-Ⅱa2 Cervical Cancer Patients Among Three Kinds of Therapeutic Regimens |
| title_short | Comparison of Survival and Postoperative Complication of Stage Ⅰb2-Ⅱa2 Cervical Cancer Patients Among Three Kinds of Therapeutic Regimens |
| title_sort | comparison of survival and postoperative complication of stage ib2 iia2 cervical cancer patients among three kinds of therapeutic regimens |
| topic | surgery neoadjuvant chemotherapy concurrent chemoradiotherapy cervical cancer survival condition postoperative complication |
| url | http://html.rhhz.net/ZLFZYJ/html/8578.2019.18.0605.htm |
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