The safety and efficacy of Glubran 2 as biliostatic agent in liver resection
Abstract Background Biloma, an encapsulated collection of bile outside the biliary tree, supported by a predominantly iatrogenic biliary fistula, and bile likeage are two of the most important surgical complications after liver resection. We, hypothesized to conduct a project aimed to prevent, or re...
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| Format: | Article |
| Language: | English |
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BMC
2021-03-01
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| Series: | Infectious Agents and Cancer |
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| Online Access: | https://doi.org/10.1186/s13027-021-00358-3 |
| _version_ | 1818724509507649536 |
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| author | Renato Patrone Vincenza Granata Andrea Belli Raffaele Palaia Vittorio Albino Mauro Piccirillo Roberta Fusco Fabiana Tatangelo Guglielmo Nasti Antonio Avallone Francesco Izzo |
| author_facet | Renato Patrone Vincenza Granata Andrea Belli Raffaele Palaia Vittorio Albino Mauro Piccirillo Roberta Fusco Fabiana Tatangelo Guglielmo Nasti Antonio Avallone Francesco Izzo |
| author_sort | Renato Patrone |
| collection | DOAJ |
| description | Abstract Background Biloma, an encapsulated collection of bile outside the biliary tree, supported by a predominantly iatrogenic biliary fistula, and bile likeage are two of the most important surgical complications after liver resection. We, hypothesized to conduct a project aimed to prevent, or reduce, the formation of biloma or biliary fistula applying on the hepatic resection area the cyanoacrylate glue (Glubran2). Methods We searched in our surgical database all patients underwent liver resection for mCRC from January 2013 to December 2018 and we found a total of 510 patients. 205 patients for Group A (study population: included patients in which we have used Glubran2 during surgical procedure) and 113 patients for Group B (control group), were enrolled. Results In both Groups no patients died during hospitalization and the 30-day mortality was 0 %. During follow-up in Group A, a biliary fistula was found in 2 patients (1 %) versus 3 patients in the Group B (2,6 %). In patients enrolled in Group A no adverse event were reported relate to the use of Glubran2. Conclusions It is possible to affirm that the use of Glubran2 as biliostatic agent after liver resection is useful to prevent bile leakage complication and biloma formation and its use demonstrated to be safe and feasible during liver surgery. |
| first_indexed | 2024-12-17T21:27:33Z |
| format | Article |
| id | doaj.art-cc74c9dde9a54d36b5303b4a0bf81881 |
| institution | Directory Open Access Journal |
| issn | 1750-9378 |
| language | English |
| last_indexed | 2024-12-17T21:27:33Z |
| publishDate | 2021-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Infectious Agents and Cancer |
| spelling | doaj.art-cc74c9dde9a54d36b5303b4a0bf818812022-12-21T21:32:00ZengBMCInfectious Agents and Cancer1750-93782021-03-011611710.1186/s13027-021-00358-3The safety and efficacy of Glubran 2 as biliostatic agent in liver resectionRenato Patrone0Vincenza Granata1Andrea Belli2Raffaele Palaia3Vittorio Albino4Mauro Piccirillo5Roberta Fusco6Fabiana Tatangelo7Guglielmo Nasti8Antonio Avallone9Francesco Izzo10PhD ICTH, University Federico IIDepartment of Support to Cancer Pathways Diagnostics Area, Radiology Unit, “Istituto Nazionale Tumori IRCCS Fondazione Pascale – IRCCS di Napoli”Department Corp-S Care and Research of Cancer of the Abdominal District, Hepatobiliary Unit, “Istituto Nazionale Tumori IRCCS Fondazione G. Pascale – Napoli”Department Corp-S Care and Research of Cancer of the Abdominal District, Hepatobiliary Unit, “Istituto Nazionale Tumori IRCCS Fondazione G. Pascale – Napoli”Department Corp-S Care and Research of Cancer of the Abdominal District, Hepatobiliary Unit, “Istituto Nazionale Tumori IRCCS Fondazione G. Pascale – Napoli”Department Corp-S Care and Research of Cancer of the Abdominal District, Hepatobiliary Unit, “Istituto Nazionale Tumori IRCCS Fondazione G. Pascale – Napoli”Department of Support to Cancer Pathways Diagnostics Area, Radiology Unit, “Istituto Nazionale Tumori IRCCS Fondazione Pascale – IRCCS di Napoli”Department of Support to Cancer Pathways Diagnostics Area, Pathology and Cytopathology Unit, “Istituto Nazionale Tumori IRCCS Fondazione G. Pascale – IRCCS Napoli”Department Corp-S Care and Research of Cancer of the Abdominal District, Oncology Unit, “Istituto Nazionale Tumori IRCCS Fondazione G. Pascale – IRCCS Napoli”Department Corp-S Care and Research of Cancer of the Abdominal District, Oncology Unit, “Istituto Nazionale Tumori IRCCS Fondazione G. Pascale – IRCCS Napoli”Department Corp-S Care and Research of Cancer of the Abdominal District, Hepatobiliary Unit, “Istituto Nazionale Tumori IRCCS Fondazione G. Pascale – Napoli”Abstract Background Biloma, an encapsulated collection of bile outside the biliary tree, supported by a predominantly iatrogenic biliary fistula, and bile likeage are two of the most important surgical complications after liver resection. We, hypothesized to conduct a project aimed to prevent, or reduce, the formation of biloma or biliary fistula applying on the hepatic resection area the cyanoacrylate glue (Glubran2). Methods We searched in our surgical database all patients underwent liver resection for mCRC from January 2013 to December 2018 and we found a total of 510 patients. 205 patients for Group A (study population: included patients in which we have used Glubran2 during surgical procedure) and 113 patients for Group B (control group), were enrolled. Results In both Groups no patients died during hospitalization and the 30-day mortality was 0 %. During follow-up in Group A, a biliary fistula was found in 2 patients (1 %) versus 3 patients in the Group B (2,6 %). In patients enrolled in Group A no adverse event were reported relate to the use of Glubran2. Conclusions It is possible to affirm that the use of Glubran2 as biliostatic agent after liver resection is useful to prevent bile leakage complication and biloma formation and its use demonstrated to be safe and feasible during liver surgery.https://doi.org/10.1186/s13027-021-00358-3Liver metastasesBile duct injuryHepatic resectionChemotherapyEfficacy |
| spellingShingle | Renato Patrone Vincenza Granata Andrea Belli Raffaele Palaia Vittorio Albino Mauro Piccirillo Roberta Fusco Fabiana Tatangelo Guglielmo Nasti Antonio Avallone Francesco Izzo The safety and efficacy of Glubran 2 as biliostatic agent in liver resection Infectious Agents and Cancer Liver metastases Bile duct injury Hepatic resection Chemotherapy Efficacy |
| title | The safety and efficacy of Glubran 2 as biliostatic agent in liver resection |
| title_full | The safety and efficacy of Glubran 2 as biliostatic agent in liver resection |
| title_fullStr | The safety and efficacy of Glubran 2 as biliostatic agent in liver resection |
| title_full_unstemmed | The safety and efficacy of Glubran 2 as biliostatic agent in liver resection |
| title_short | The safety and efficacy of Glubran 2 as biliostatic agent in liver resection |
| title_sort | safety and efficacy of glubran 2 as biliostatic agent in liver resection |
| topic | Liver metastases Bile duct injury Hepatic resection Chemotherapy Efficacy |
| url | https://doi.org/10.1186/s13027-021-00358-3 |
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