UBR7 inhibits HCC tumorigenesis by targeting Keap1/Nrf2/Bach1/HK2 and glycolysis

UBR7 inhibits HCC tumorigenesis by targeting Keap1/Nrf2/Bach1/HK2 and glycolysis

Abstract Background Glycolysis metabolism is an attractive target for cancer therapy. Reprogramming metabolic pathways could improve the ability of metabolic inhibitors to suppress cancers with limited treatment options. The ubiquitin–proteasome system facilitates the turnover of most intracellular...

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Bibliographic Details
Main Authors: Liang Zhao, Min Kang, Xiaomeng Liu, Zhenran Wang, Yan Wang, Haiqiang Chen, Wenhui Liu, Shiqian Liu, Baibei Li, Chong Li, Antao Chang, Bo Tang
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Hepatocellular carcinoma
UBR7
Keap1-Nrf2-Bach1 signaling
Glycolysis
Monoubiquitination
Online Access:https://doi.org/10.1186/s13046-022-02528-6

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