Gestational Diabetes Is Uniquely Associated With Altered Early Seeding of the Infant Gut Microbiota
Gestational diabetes mellitus (GDM) is a worldwide public health problem affecting up to 27% of pregnancies with high predictive values for childhood obesity and inflammatory diseases. Compromised seeding of the infant gut microbiota is a risk factor for immunologic and metabolic diseases in the off...
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| Format: | Article |
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Frontiers Media S.A.
2020-11-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2020.603021/full |
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| author | Taylor K. Soderborg Charles M. Carpenter Rachel C. Janssen Tiffany L. Weir Charles E. Robertson Diana Ir Bridget E. Young Nancy F. Krebs Teri L. Hernandez Teri L. Hernandez Linda A. Barbour Linda A. Barbour Daniel N. Frank Miranda Kroehl Jacob E. Friedman Jacob E. Friedman |
| author_facet | Taylor K. Soderborg Charles M. Carpenter Rachel C. Janssen Tiffany L. Weir Charles E. Robertson Diana Ir Bridget E. Young Nancy F. Krebs Teri L. Hernandez Teri L. Hernandez Linda A. Barbour Linda A. Barbour Daniel N. Frank Miranda Kroehl Jacob E. Friedman Jacob E. Friedman |
| author_sort | Taylor K. Soderborg |
| collection | DOAJ |
| description | Gestational diabetes mellitus (GDM) is a worldwide public health problem affecting up to 27% of pregnancies with high predictive values for childhood obesity and inflammatory diseases. Compromised seeding of the infant gut microbiota is a risk factor for immunologic and metabolic diseases in the offspring; however, how GDM along with maternal obesity interact to alter colonization remains unknown. We hypothesized that GDM individually and in combination with maternal overweight/obesity would alter gut microbial composition, diversity, and short-chain fatty acid (SCFA) levels in neonates. We investigated 46 full-term neonates born to normal-weight or overweight/obese mothers with and without GDM, accounting for confounders including cesarean delivery, lack of breastfeeding, and exposure to antibiotics. Gut microbiota in 2-week-old neonates born to mothers with GDM exhibited differences in abundance of 26 microbial taxa; 14 of which showed persistent differential abundance after adjusting for pre-pregnancy BMI. Key pioneering gut taxa, including potentially important taxa for establishing neonatal immunity, were reduced. Lactobacillus, Flavonifractor, Erysipelotrichaceae, and unspecified families in Gammaproteobacteria were significantly reduced in neonates from mothers with GDM. GDM was associated with an increase in microbes involved in suppressing early immune cell function (Phascolarctobacterium). No differences in infant stool SCFA levels by maternal phenotype were noted; however, significant correlations were found between microbial abundances and SCFA levels in neonates. Our results suggest that GDM alone and together with maternal overweight/obesity uniquely influences seeding of specific infant microbiota in patterns that set the stage for future risk of inflammatory and metabolic disease. |
| first_indexed | 2024-12-13T18:46:20Z |
| format | Article |
| id | doaj.art-cc75e385ad1540c09e09def7844d653e |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-13T18:46:20Z |
| publishDate | 2020-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-cc75e385ad1540c09e09def7844d653e2022-12-21T23:35:04ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922020-11-011110.3389/fendo.2020.603021603021Gestational Diabetes Is Uniquely Associated With Altered Early Seeding of the Infant Gut MicrobiotaTaylor K. Soderborg0Charles M. Carpenter1Rachel C. Janssen2Tiffany L. Weir3Charles E. Robertson4Diana Ir5Bridget E. Young6Nancy F. Krebs7Teri L. Hernandez8Teri L. Hernandez9Linda A. Barbour10Linda A. Barbour11Daniel N. Frank12Miranda Kroehl13Jacob E. Friedman14Jacob E. Friedman15Department of Pediatrics, Section of Neonatology, University of Colorado Anschutz Medical Campus, Aurora, CO, United StatesDivision of Biostatistics and Epidemiology, University of Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, United StatesDepartment of Pediatrics, Section of Neonatology, University of Colorado Anschutz Medical Campus, Aurora, CO, United StatesDepartment of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, United StatesDepartment of Medicine, Division of Infectious Disease, University of Colorado Anschutz Medical Campus, Aurora, CO, United StatesDepartment of Medicine, Division of Infectious Disease, University of Colorado Anschutz Medical Campus, Aurora, CO, United StatesDepartment of Pediatrics, Section of Nutrition, University of Colorado Anschutz Medical Campus, Aurora, CO, United StatesDepartment of Pediatrics, Section of Nutrition, University of Colorado Anschutz Medical Campus, Aurora, CO, United StatesDepartment of Medicine, Division of Endocrinology, Metabolism & Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, United StatesCollege of Nursing, University of Colorado Anschutz Medical Campus, Aurora, CO, United StatesDepartment of Medicine, Division of Endocrinology, Metabolism & Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, United StatesDepartment of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United StatesDepartment of Medicine, Division of Infectious Disease, University of Colorado Anschutz Medical Campus, Aurora, CO, United StatesDivision of Biostatistics and Epidemiology, University of Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, United StatesDepartment of Pediatrics, Section of Neonatology, University of Colorado Anschutz Medical Campus, Aurora, CO, United StatesDepartment of Medicine, Division of Endocrinology, Metabolism & Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, United StatesGestational diabetes mellitus (GDM) is a worldwide public health problem affecting up to 27% of pregnancies with high predictive values for childhood obesity and inflammatory diseases. Compromised seeding of the infant gut microbiota is a risk factor for immunologic and metabolic diseases in the offspring; however, how GDM along with maternal obesity interact to alter colonization remains unknown. We hypothesized that GDM individually and in combination with maternal overweight/obesity would alter gut microbial composition, diversity, and short-chain fatty acid (SCFA) levels in neonates. We investigated 46 full-term neonates born to normal-weight or overweight/obese mothers with and without GDM, accounting for confounders including cesarean delivery, lack of breastfeeding, and exposure to antibiotics. Gut microbiota in 2-week-old neonates born to mothers with GDM exhibited differences in abundance of 26 microbial taxa; 14 of which showed persistent differential abundance after adjusting for pre-pregnancy BMI. Key pioneering gut taxa, including potentially important taxa for establishing neonatal immunity, were reduced. Lactobacillus, Flavonifractor, Erysipelotrichaceae, and unspecified families in Gammaproteobacteria were significantly reduced in neonates from mothers with GDM. GDM was associated with an increase in microbes involved in suppressing early immune cell function (Phascolarctobacterium). No differences in infant stool SCFA levels by maternal phenotype were noted; however, significant correlations were found between microbial abundances and SCFA levels in neonates. Our results suggest that GDM alone and together with maternal overweight/obesity uniquely influences seeding of specific infant microbiota in patterns that set the stage for future risk of inflammatory and metabolic disease.https://www.frontiersin.org/articles/10.3389/fendo.2020.603021/fullgestational diabetesmaternal obesitymicrobiotaexcess gestational weight gaininfantshort-chain fatty acids |
| spellingShingle | Taylor K. Soderborg Charles M. Carpenter Rachel C. Janssen Tiffany L. Weir Charles E. Robertson Diana Ir Bridget E. Young Nancy F. Krebs Teri L. Hernandez Teri L. Hernandez Linda A. Barbour Linda A. Barbour Daniel N. Frank Miranda Kroehl Jacob E. Friedman Jacob E. Friedman Gestational Diabetes Is Uniquely Associated With Altered Early Seeding of the Infant Gut Microbiota Frontiers in Endocrinology gestational diabetes maternal obesity microbiota excess gestational weight gain infant short-chain fatty acids |
| title | Gestational Diabetes Is Uniquely Associated With Altered Early Seeding of the Infant Gut Microbiota |
| title_full | Gestational Diabetes Is Uniquely Associated With Altered Early Seeding of the Infant Gut Microbiota |
| title_fullStr | Gestational Diabetes Is Uniquely Associated With Altered Early Seeding of the Infant Gut Microbiota |
| title_full_unstemmed | Gestational Diabetes Is Uniquely Associated With Altered Early Seeding of the Infant Gut Microbiota |
| title_short | Gestational Diabetes Is Uniquely Associated With Altered Early Seeding of the Infant Gut Microbiota |
| title_sort | gestational diabetes is uniquely associated with altered early seeding of the infant gut microbiota |
| topic | gestational diabetes maternal obesity microbiota excess gestational weight gain infant short-chain fatty acids |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2020.603021/full |
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