UCHL1 Regulates Radiation Lung Injury via Sphingosine Kinase-1

UCHL1 Regulates Radiation Lung Injury via Sphingosine Kinase-1

GADD45a is a gene we previously reported as a mediator of responses to acute lung injury. GADD45a−/− mice express decreased Akt and increased Akt ubiquitination due to the reduced expression of UCHL1 (ubiquitin c-terminal hydrolase L1), a deubiquitinating enzyme, while GADD45a−/− mice have increased...

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Bibliographic Details
Main Authors: Yulia Epshtein, Biji Mathew, Weiguo Chen, Jeffrey R. Jacobson
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Cells
Subjects:
UCHL1
sphingosine kinase 1
radiation lung injury
Online Access:https://www.mdpi.com/2073-4409/12/19/2405

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