Tissue engineering applications in otolaryngology—The state of translation
Abstract While tissue engineering holds significant potential to address current limitations in reconstructive surgery of the head and neck, few constructs have made their way into routine clinical use. In this review, we aim to appraise the state of head and neck tissue engineering over the past fi...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-08-01
|
| Series: | Laryngoscope Investigative Otolaryngology |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/lio2.416 |
| _version_ | 1818334994123194368 |
|---|---|
| author | Weston L. Niermeyer Cole Rodman Michael M. Li Tendy Chiang |
| author_facet | Weston L. Niermeyer Cole Rodman Michael M. Li Tendy Chiang |
| author_sort | Weston L. Niermeyer |
| collection | DOAJ |
| description | Abstract While tissue engineering holds significant potential to address current limitations in reconstructive surgery of the head and neck, few constructs have made their way into routine clinical use. In this review, we aim to appraise the state of head and neck tissue engineering over the past five years, with a specific focus on otologic, nasal, craniofacial bone, and laryngotracheal applications. A comprehensive scoping search of the PubMed database was performed and over 2000 article hits were returned with 290 articles included in the final review. These publications have addressed the hallmark characteristics of tissue engineering (cellular source, scaffold, and growth signaling) for head and neck anatomical sites. While there have been promising reports of effective tissue engineered interventions in small groups of human patients, the majority of research remains constrained to in vitro and in vivo studies aimed at furthering the understanding of the biological processes involved in tissue engineering. Further, differences in functional and cosmetic properties of the ear, nose, airway, and craniofacial bone affect the emphasis of investigation at each site. While otolaryngologists currently play a role in tissue engineering translational research, continued multidisciplinary efforts will likely be required to push the state of translation towards tissue‐engineered constructs available for routine clinical use. Level of Evidence NA. |
| first_indexed | 2024-12-13T14:16:22Z |
| format | Article |
| id | doaj.art-cc778a53942044fa855e3757c9eb0c9f |
| institution | Directory Open Access Journal |
| issn | 2378-8038 |
| language | English |
| last_indexed | 2024-12-13T14:16:22Z |
| publishDate | 2020-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Laryngoscope Investigative Otolaryngology |
| spelling | doaj.art-cc778a53942044fa855e3757c9eb0c9f2022-12-21T23:42:18ZengWileyLaryngoscope Investigative Otolaryngology2378-80382020-08-015463064810.1002/lio2.416Tissue engineering applications in otolaryngology—The state of translationWeston L. Niermeyer0Cole Rodman1Michael M. Li2Tendy Chiang3Department of Otolaryngology Nationwide Children's Hospital Columbus Ohio USAThe Ohio State University College of Medicine Columbus Ohio USADepartment of Otolaryngology—Head and Neck Surgery The Ohio State University Wexner Medical Center Columbus Ohio USADepartment of Otolaryngology Nationwide Children's Hospital Columbus Ohio USAAbstract While tissue engineering holds significant potential to address current limitations in reconstructive surgery of the head and neck, few constructs have made their way into routine clinical use. In this review, we aim to appraise the state of head and neck tissue engineering over the past five years, with a specific focus on otologic, nasal, craniofacial bone, and laryngotracheal applications. A comprehensive scoping search of the PubMed database was performed and over 2000 article hits were returned with 290 articles included in the final review. These publications have addressed the hallmark characteristics of tissue engineering (cellular source, scaffold, and growth signaling) for head and neck anatomical sites. While there have been promising reports of effective tissue engineered interventions in small groups of human patients, the majority of research remains constrained to in vitro and in vivo studies aimed at furthering the understanding of the biological processes involved in tissue engineering. Further, differences in functional and cosmetic properties of the ear, nose, airway, and craniofacial bone affect the emphasis of investigation at each site. While otolaryngologists currently play a role in tissue engineering translational research, continued multidisciplinary efforts will likely be required to push the state of translation towards tissue‐engineered constructs available for routine clinical use. Level of Evidence NA.https://doi.org/10.1002/lio2.416auricularcraniofacialnasalregenerative medicinetissue engineeringtracheal |
| spellingShingle | Weston L. Niermeyer Cole Rodman Michael M. Li Tendy Chiang Tissue engineering applications in otolaryngology—The state of translation Laryngoscope Investigative Otolaryngology auricular craniofacial nasal regenerative medicine tissue engineering tracheal |
| title | Tissue engineering applications in otolaryngology—The state of translation |
| title_full | Tissue engineering applications in otolaryngology—The state of translation |
| title_fullStr | Tissue engineering applications in otolaryngology—The state of translation |
| title_full_unstemmed | Tissue engineering applications in otolaryngology—The state of translation |
| title_short | Tissue engineering applications in otolaryngology—The state of translation |
| title_sort | tissue engineering applications in otolaryngology the state of translation |
| topic | auricular craniofacial nasal regenerative medicine tissue engineering tracheal |
| url | https://doi.org/10.1002/lio2.416 |
| work_keys_str_mv | AT westonlniermeyer tissueengineeringapplicationsinotolaryngologythestateoftranslation AT colerodman tissueengineeringapplicationsinotolaryngologythestateoftranslation AT michaelmli tissueengineeringapplicationsinotolaryngologythestateoftranslation AT tendychiang tissueengineeringapplicationsinotolaryngologythestateoftranslation |