Supercritical Fluid Technologies for the Incorporation of Synthetic and Natural Active Compounds into Materials for Drug Formulation and Delivery
Various active compounds isolated from natural sources exhibit remarkable benefits, making them attractive for pharmaceutical and biomedical applications, such as antioxidant, antimicrobial, and anti-inflammatory activities, which contribute to the treatment of cardiovascular diseases, neurodegenera...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-08-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/14/8/1670 |
| _version_ | 1797408398998765568 |
|---|---|
| author | Katja Andrina Kravanja Matjaž Finšgar Željko Knez Maša Knez Marevci |
| author_facet | Katja Andrina Kravanja Matjaž Finšgar Željko Knez Maša Knez Marevci |
| author_sort | Katja Andrina Kravanja |
| collection | DOAJ |
| description | Various active compounds isolated from natural sources exhibit remarkable benefits, making them attractive for pharmaceutical and biomedical applications, such as antioxidant, antimicrobial, and anti-inflammatory activities, which contribute to the treatment of cardiovascular diseases, neurodegenerative disorders, various types of cancer, diabetes, and obesity. However, their major drawbacks are their reactivity, instability, relatively poor water solubility, and consequently low bioavailability. Synthetic drugs often face similar challenges associated with inadequate solubility or burst release in gastrointestinal media, despite being otherwise a safe and effective option for the treatment of numerous diseases. Therefore, drug-eluting pharmaceutical formulations have been of great importance over the years in efforts to improve the bioavailability of active compounds by increasing their solubility and achieving their controlled release in body media. This review highlights the success of the fabrication of micro- and nanoformulations using environmentally friendly supercritical fluid technologies for the processing and incorporation of active compounds. Several novel approaches, namely micronization to produce micro- and nano-sized particles, supercritical drying to produce aerogels, supercritical foaming, and supercritical solvent impregnation, are described in detail, along with the currently available drug delivery data for these formulations. |
| first_indexed | 2024-03-09T03:57:54Z |
| format | Article |
| id | doaj.art-cc783c223b954150a1968e553105c2a1 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T03:57:54Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-cc783c223b954150a1968e553105c2a12023-12-03T14:17:38ZengMDPI AGPharmaceutics1999-49232022-08-01148167010.3390/pharmaceutics14081670Supercritical Fluid Technologies for the Incorporation of Synthetic and Natural Active Compounds into Materials for Drug Formulation and DeliveryKatja Andrina Kravanja0Matjaž Finšgar1Željko Knez2Maša Knez Marevci3Faculty of Chemistry and Chemical Engineering, University of Maribor, Smetanova 17, 2000 Maribor, SloveniaFaculty of Chemistry and Chemical Engineering, University of Maribor, Smetanova 17, 2000 Maribor, SloveniaFaculty of Chemistry and Chemical Engineering, University of Maribor, Smetanova 17, 2000 Maribor, SloveniaFaculty of Chemistry and Chemical Engineering, University of Maribor, Smetanova 17, 2000 Maribor, SloveniaVarious active compounds isolated from natural sources exhibit remarkable benefits, making them attractive for pharmaceutical and biomedical applications, such as antioxidant, antimicrobial, and anti-inflammatory activities, which contribute to the treatment of cardiovascular diseases, neurodegenerative disorders, various types of cancer, diabetes, and obesity. However, their major drawbacks are their reactivity, instability, relatively poor water solubility, and consequently low bioavailability. Synthetic drugs often face similar challenges associated with inadequate solubility or burst release in gastrointestinal media, despite being otherwise a safe and effective option for the treatment of numerous diseases. Therefore, drug-eluting pharmaceutical formulations have been of great importance over the years in efforts to improve the bioavailability of active compounds by increasing their solubility and achieving their controlled release in body media. This review highlights the success of the fabrication of micro- and nanoformulations using environmentally friendly supercritical fluid technologies for the processing and incorporation of active compounds. Several novel approaches, namely micronization to produce micro- and nano-sized particles, supercritical drying to produce aerogels, supercritical foaming, and supercritical solvent impregnation, are described in detail, along with the currently available drug delivery data for these formulations.https://www.mdpi.com/1999-4923/14/8/1670supercritical fluid technologiesactive compoundsdrug formulationdrug delivery |
| spellingShingle | Katja Andrina Kravanja Matjaž Finšgar Željko Knez Maša Knez Marevci Supercritical Fluid Technologies for the Incorporation of Synthetic and Natural Active Compounds into Materials for Drug Formulation and Delivery Pharmaceutics supercritical fluid technologies active compounds drug formulation drug delivery |
| title | Supercritical Fluid Technologies for the Incorporation of Synthetic and Natural Active Compounds into Materials for Drug Formulation and Delivery |
| title_full | Supercritical Fluid Technologies for the Incorporation of Synthetic and Natural Active Compounds into Materials for Drug Formulation and Delivery |
| title_fullStr | Supercritical Fluid Technologies for the Incorporation of Synthetic and Natural Active Compounds into Materials for Drug Formulation and Delivery |
| title_full_unstemmed | Supercritical Fluid Technologies for the Incorporation of Synthetic and Natural Active Compounds into Materials for Drug Formulation and Delivery |
| title_short | Supercritical Fluid Technologies for the Incorporation of Synthetic and Natural Active Compounds into Materials for Drug Formulation and Delivery |
| title_sort | supercritical fluid technologies for the incorporation of synthetic and natural active compounds into materials for drug formulation and delivery |
| topic | supercritical fluid technologies active compounds drug formulation drug delivery |
| url | https://www.mdpi.com/1999-4923/14/8/1670 |
| work_keys_str_mv | AT katjaandrinakravanja supercriticalfluidtechnologiesfortheincorporationofsyntheticandnaturalactivecompoundsintomaterialsfordrugformulationanddelivery AT matjazfinsgar supercriticalfluidtechnologiesfortheincorporationofsyntheticandnaturalactivecompoundsintomaterialsfordrugformulationanddelivery AT zeljkoknez supercriticalfluidtechnologiesfortheincorporationofsyntheticandnaturalactivecompoundsintomaterialsfordrugformulationanddelivery AT masaknezmarevci supercriticalfluidtechnologiesfortheincorporationofsyntheticandnaturalactivecompoundsintomaterialsfordrugformulationanddelivery |