Neuroparacoccidioidomycosis: A 13-Year Cohort Study, Rio de Janeiro, Brazil
Neuroparacoccidioidomycosis (NPCM) is a rare and severe clinical presentation of paracoccidioidomycosis (PCM). We performed a retrospective cohort study at the Evandro Chagas National Institute of Infectious Diseases (INI/Fiocruz), a reference center for PCM in the state of Rio de Janeiro, Brazil. A...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/6/4/303 |
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| author | Priscila Marques de Macedo Eduardo Mastrangelo Marinho Falcão Dayvison Francis Saraiva Freitas Andréa d’Avila Freitas Ziadir Francisco Coutinho Mauro de Medeiros Muniz Rosely Maria Zancopé-Oliveira Rodrigo Almeida-Paes Marcus Tulius Teixeira da Silva Antonio Carlos Francesconi do Valle |
| author_facet | Priscila Marques de Macedo Eduardo Mastrangelo Marinho Falcão Dayvison Francis Saraiva Freitas Andréa d’Avila Freitas Ziadir Francisco Coutinho Mauro de Medeiros Muniz Rosely Maria Zancopé-Oliveira Rodrigo Almeida-Paes Marcus Tulius Teixeira da Silva Antonio Carlos Francesconi do Valle |
| author_sort | Priscila Marques de Macedo |
| collection | DOAJ |
| description | Neuroparacoccidioidomycosis (NPCM) is a rare and severe clinical presentation of paracoccidioidomycosis (PCM). We performed a retrospective cohort study at the Evandro Chagas National Institute of Infectious Diseases (INI/Fiocruz), a reference center for PCM in the state of Rio de Janeiro, Brazil. All cases of PCM admitted to the INI/Fiocruz from January 2007 to December 2019 were reviewed. Eight (3.9%) among 207 patients met the diagnostic criteria for NPCM. The mean age was 44.6 years and the male:female ratio was 7:1. All cases presented multifocal disease, 5 (62.5%) the chronic form and 3 (37.5%) the acute/subacute form. All patients presented the pseudotumoral pattern and 6 (75.0%) had multiple lesions in the cerebral hemispheres. Seizures and motor symptoms were the most frequent clinical manifestations (50.0%, each). The treatment of choice was sulfamethoxazole/trimethoprim (SMZ-TMP) and fluconazole, in association (87.5%). Most patients responded well to the treatment. Sequela and death occurred in one (12.5%) patient, each. |
| first_indexed | 2024-03-10T14:43:18Z |
| format | Article |
| id | doaj.art-cc78d481068a4ed3ad82ee205c2c21c0 |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-10T14:43:18Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-cc78d481068a4ed3ad82ee205c2c21c02023-11-20T21:38:46ZengMDPI AGJournal of Fungi2309-608X2020-11-016430310.3390/jof6040303Neuroparacoccidioidomycosis: A 13-Year Cohort Study, Rio de Janeiro, BrazilPriscila Marques de Macedo0Eduardo Mastrangelo Marinho Falcão1Dayvison Francis Saraiva Freitas2Andréa d’Avila Freitas3Ziadir Francisco Coutinho4Mauro de Medeiros Muniz5Rosely Maria Zancopé-Oliveira6Rodrigo Almeida-Paes7Marcus Tulius Teixeira da Silva8Antonio Carlos Francesconi do Valle9Clinical Research Laboratory on Infectious Dermatology, Evandro Chagas National Institute of Infectious Diseases, Fiocruz, Rio de Janeiro 21040-900, BrazilClinical Research Laboratory on Infectious Dermatology, Evandro Chagas National Institute of Infectious Diseases, Fiocruz, Rio de Janeiro 21040-900, BrazilClinical Research Laboratory on Infectious Dermatology, Evandro Chagas National Institute of Infectious Diseases, Fiocruz, Rio de Janeiro 21040-900, BrazilDepartment of Inpatient Health Care, Evandro Chagas National Institute of Infectious Diseases, Fiocruz, Rio de Janeiro 21040-900, BrazilGermano Sinval Faria School Health Center, Sergio Arouca National School of Public Health, Fiocruz, Rio de Janeiro 21040-900, BrazilMycology Laboratory, Evandro Chagas National Institute of Infectious Diseases, Fiocruz, Rio de Janeiro 21040-900, BrazilMycology Laboratory, Evandro Chagas National Institute of Infectious Diseases, Fiocruz, Rio de Janeiro 21040-900, BrazilMycology Laboratory, Evandro Chagas National Institute of Infectious Diseases, Fiocruz, Rio de Janeiro 21040-900, BrazilClinical Research Laboratory on Neuroinfectious Diseases, Evandro Chagas National Institute of Infectious Diseases, Fiocruz, Rio de Janeiro 21040-900, BrazilClinical Research Laboratory on Infectious Dermatology, Evandro Chagas National Institute of Infectious Diseases, Fiocruz, Rio de Janeiro 21040-900, BrazilNeuroparacoccidioidomycosis (NPCM) is a rare and severe clinical presentation of paracoccidioidomycosis (PCM). We performed a retrospective cohort study at the Evandro Chagas National Institute of Infectious Diseases (INI/Fiocruz), a reference center for PCM in the state of Rio de Janeiro, Brazil. All cases of PCM admitted to the INI/Fiocruz from January 2007 to December 2019 were reviewed. Eight (3.9%) among 207 patients met the diagnostic criteria for NPCM. The mean age was 44.6 years and the male:female ratio was 7:1. All cases presented multifocal disease, 5 (62.5%) the chronic form and 3 (37.5%) the acute/subacute form. All patients presented the pseudotumoral pattern and 6 (75.0%) had multiple lesions in the cerebral hemispheres. Seizures and motor symptoms were the most frequent clinical manifestations (50.0%, each). The treatment of choice was sulfamethoxazole/trimethoprim (SMZ-TMP) and fluconazole, in association (87.5%). Most patients responded well to the treatment. Sequela and death occurred in one (12.5%) patient, each.https://www.mdpi.com/2309-608X/6/4/303neuroparacoccidioidomycosisparacoccidioidomycosisneglected diseases<i>Paracoccidioides</i>central nervous system |
| spellingShingle | Priscila Marques de Macedo Eduardo Mastrangelo Marinho Falcão Dayvison Francis Saraiva Freitas Andréa d’Avila Freitas Ziadir Francisco Coutinho Mauro de Medeiros Muniz Rosely Maria Zancopé-Oliveira Rodrigo Almeida-Paes Marcus Tulius Teixeira da Silva Antonio Carlos Francesconi do Valle Neuroparacoccidioidomycosis: A 13-Year Cohort Study, Rio de Janeiro, Brazil Journal of Fungi neuroparacoccidioidomycosis paracoccidioidomycosis neglected diseases <i>Paracoccidioides</i> central nervous system |
| title | Neuroparacoccidioidomycosis: A 13-Year Cohort Study, Rio de Janeiro, Brazil |
| title_full | Neuroparacoccidioidomycosis: A 13-Year Cohort Study, Rio de Janeiro, Brazil |
| title_fullStr | Neuroparacoccidioidomycosis: A 13-Year Cohort Study, Rio de Janeiro, Brazil |
| title_full_unstemmed | Neuroparacoccidioidomycosis: A 13-Year Cohort Study, Rio de Janeiro, Brazil |
| title_short | Neuroparacoccidioidomycosis: A 13-Year Cohort Study, Rio de Janeiro, Brazil |
| title_sort | neuroparacoccidioidomycosis a 13 year cohort study rio de janeiro brazil |
| topic | neuroparacoccidioidomycosis paracoccidioidomycosis neglected diseases <i>Paracoccidioides</i> central nervous system |
| url | https://www.mdpi.com/2309-608X/6/4/303 |
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