Adequacy of Severe Malaria Markers and Prognostic Scores in an Intensive Care Unit in Luanda, Angola: A Clinical Study
Severe <i>Plasmodium falciparum</i> malaria remains the primary cause of mortality in several African countries, including Angola, where severe malaria patient admission into intensive care units (ICU) is mandatory. The present observational and prospective study enrolled 101 consecutive...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/12/3862 |
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| author | Maria Lina Antunes Jorge Seixas Humberto E. Ferreira Marcelo Sousa Silva |
| author_facet | Maria Lina Antunes Jorge Seixas Humberto E. Ferreira Marcelo Sousa Silva |
| author_sort | Maria Lina Antunes |
| collection | DOAJ |
| description | Severe <i>Plasmodium falciparum</i> malaria remains the primary cause of mortality in several African countries, including Angola, where severe malaria patient admission into intensive care units (ICU) is mandatory. The present observational and prospective study enrolled 101 consecutive severe malaria patients admitted at the ICU of Américo Boavida University Hospital (Luanda, Angola). Malaria was confirmed by microscopy and RDT, and WHO criteria were used to define severe malaria. The Sequential Organ Failure Assessment (SOFA) score was used to monitor organ dysfunctions. Surviving and nonsurviving patients were compared using bivariate statistical methods. Two-step cluster analysis was used to find discriminant organ dysfunctions that may correlate better with the observed mortality (16.8%), which was much lower than the one generated by the SOFA score. The study population was young, and 87% of the patients were local native residents. There was no statistically significant correlation between the parasitemia and the outcome. Hematological and cerebral dysfunctions were prevalent but were not discriminant when cluster analyses were performed to detect homogeneous subgroups of patients. In conclusion, the SOFA score was readily applicable and efficient in monitoring daily organ dysfunction but was not effective enough in predicting the outcome of severe malaria patients. |
| first_indexed | 2024-03-10T14:30:36Z |
| format | Article |
| id | doaj.art-cc7900620b244961923bc4b4fbb1eba8 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T14:30:36Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-cc7900620b244961923bc4b4fbb1eba82023-11-20T22:38:56ZengMDPI AGJournal of Clinical Medicine2077-03832020-11-01912386210.3390/jcm9123862Adequacy of Severe Malaria Markers and Prognostic Scores in an Intensive Care Unit in Luanda, Angola: A Clinical StudyMaria Lina Antunes0Jorge Seixas1Humberto E. Ferreira2Marcelo Sousa Silva3Hospital Américo Boavida, Luanda 160963, AngolaGlobal Health and Tropical Medicine R&D Center, NOVA University, 1349-008 Lisbon, PortugalCERENA, Instituto Superior Técnico, University of Lisbon, 1349-008 Lisbon, PortugalGlobal Health and Tropical Medicine R&D Center, NOVA University, 1349-008 Lisbon, PortugalSevere <i>Plasmodium falciparum</i> malaria remains the primary cause of mortality in several African countries, including Angola, where severe malaria patient admission into intensive care units (ICU) is mandatory. The present observational and prospective study enrolled 101 consecutive severe malaria patients admitted at the ICU of Américo Boavida University Hospital (Luanda, Angola). Malaria was confirmed by microscopy and RDT, and WHO criteria were used to define severe malaria. The Sequential Organ Failure Assessment (SOFA) score was used to monitor organ dysfunctions. Surviving and nonsurviving patients were compared using bivariate statistical methods. Two-step cluster analysis was used to find discriminant organ dysfunctions that may correlate better with the observed mortality (16.8%), which was much lower than the one generated by the SOFA score. The study population was young, and 87% of the patients were local native residents. There was no statistically significant correlation between the parasitemia and the outcome. Hematological and cerebral dysfunctions were prevalent but were not discriminant when cluster analyses were performed to detect homogeneous subgroups of patients. In conclusion, the SOFA score was readily applicable and efficient in monitoring daily organ dysfunction but was not effective enough in predicting the outcome of severe malaria patients.https://www.mdpi.com/2077-0383/9/12/3862severe malaria<i>Plasmodium falciparum</i>SOFA scoreintensive care unitAngola |
| spellingShingle | Maria Lina Antunes Jorge Seixas Humberto E. Ferreira Marcelo Sousa Silva Adequacy of Severe Malaria Markers and Prognostic Scores in an Intensive Care Unit in Luanda, Angola: A Clinical Study Journal of Clinical Medicine severe malaria <i>Plasmodium falciparum</i> SOFA score intensive care unit Angola |
| title | Adequacy of Severe Malaria Markers and Prognostic Scores in an Intensive Care Unit in Luanda, Angola: A Clinical Study |
| title_full | Adequacy of Severe Malaria Markers and Prognostic Scores in an Intensive Care Unit in Luanda, Angola: A Clinical Study |
| title_fullStr | Adequacy of Severe Malaria Markers and Prognostic Scores in an Intensive Care Unit in Luanda, Angola: A Clinical Study |
| title_full_unstemmed | Adequacy of Severe Malaria Markers and Prognostic Scores in an Intensive Care Unit in Luanda, Angola: A Clinical Study |
| title_short | Adequacy of Severe Malaria Markers and Prognostic Scores in an Intensive Care Unit in Luanda, Angola: A Clinical Study |
| title_sort | adequacy of severe malaria markers and prognostic scores in an intensive care unit in luanda angola a clinical study |
| topic | severe malaria <i>Plasmodium falciparum</i> SOFA score intensive care unit Angola |
| url | https://www.mdpi.com/2077-0383/9/12/3862 |
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