Novel Adociaquinone Derivatives from the Indonesian Sponge Xestospongia sp.
Seven new adociaquinone derivatives, xestoadociaquinones A (1a), B (1b), 14-carboxy-xestoquinol sulfate (2) and xestoadociaminals A–D (3a, 3c, 4a, 4c), together with seven known compounds (5–11) were isolated from an Indonesian marine sponge Xestospongia sp. Their structures were elucidated by exte...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2015-04-01
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| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1660-3397/13/5/2617 |
| _version_ | 1798024431041249280 |
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| author | Fei He Linh H. Mai Arlette Longeon Brent R. Copp Nadège Loaëc Amandine Bescond Laurent Meijer Marie-Lise Bourguet-Kondracki |
| author_facet | Fei He Linh H. Mai Arlette Longeon Brent R. Copp Nadège Loaëc Amandine Bescond Laurent Meijer Marie-Lise Bourguet-Kondracki |
| author_sort | Fei He |
| collection | DOAJ |
| description | Seven new adociaquinone derivatives, xestoadociaquinones A (1a), B (1b), 14-carboxy-xestoquinol sulfate (2) and xestoadociaminals A–D (3a, 3c, 4a, 4c), together with seven known compounds (5–11) were isolated from an Indonesian marine sponge Xestospongia sp. Their structures were elucidated by extensive 1D and 2D NMR and mass spectrometric data. All the compounds were evaluated for their potential inhibitory activity against eight different protein kinases involved in cell proliferation, cancer, diabetes and neurodegenerative disorders as well as for their antioxidant and antibacterial activities. |
| first_indexed | 2024-04-11T18:02:28Z |
| format | Article |
| id | doaj.art-cc7a1e0c1d42437198d0b8423edf641b |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T18:02:28Z |
| publishDate | 2015-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-cc7a1e0c1d42437198d0b8423edf641b2022-12-22T04:10:26ZengMDPI AGMarine Drugs1660-33972015-04-011352617262810.3390/md13052617md13052617Novel Adociaquinone Derivatives from the Indonesian Sponge Xestospongia sp.Fei He0Linh H. Mai1Arlette Longeon2Brent R. Copp3Nadège Loaëc4Amandine Bescond5Laurent Meijer6Marie-Lise Bourguet-Kondracki7Laboratoire Molécules de Communication et Adaptation des Micro-organismes, CNRS/MNHN 7245, Muséum National d'Histoire Naturelle, 57 rue Cuvier (C.P. 54), 75005 Paris, FranceLaboratoire Molécules de Communication et Adaptation des Micro-organismes, CNRS/MNHN 7245, Muséum National d'Histoire Naturelle, 57 rue Cuvier (C.P. 54), 75005 Paris, FranceLaboratoire Molécules de Communication et Adaptation des Micro-organismes, CNRS/MNHN 7245, Muséum National d'Histoire Naturelle, 57 rue Cuvier (C.P. 54), 75005 Paris, FranceSchool of Chemical Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New ZealandManRos Therapeutics, Perharidy Research Center, 29680 Roscoff, FranceManRos Therapeutics, Perharidy Research Center, 29680 Roscoff, FranceManRos Therapeutics, Perharidy Research Center, 29680 Roscoff, FranceLaboratoire Molécules de Communication et Adaptation des Micro-organismes, CNRS/MNHN 7245, Muséum National d'Histoire Naturelle, 57 rue Cuvier (C.P. 54), 75005 Paris, FranceSeven new adociaquinone derivatives, xestoadociaquinones A (1a), B (1b), 14-carboxy-xestoquinol sulfate (2) and xestoadociaminals A–D (3a, 3c, 4a, 4c), together with seven known compounds (5–11) were isolated from an Indonesian marine sponge Xestospongia sp. Their structures were elucidated by extensive 1D and 2D NMR and mass spectrometric data. All the compounds were evaluated for their potential inhibitory activity against eight different protein kinases involved in cell proliferation, cancer, diabetes and neurodegenerative disorders as well as for their antioxidant and antibacterial activities.http://www.mdpi.com/1660-3397/13/5/2617kinase inhibitoradociaquinonexestoadociaquinone14-carboxy-xestoquinol sulfatexestoadociaminalXestospongia sp. |
| spellingShingle | Fei He Linh H. Mai Arlette Longeon Brent R. Copp Nadège Loaëc Amandine Bescond Laurent Meijer Marie-Lise Bourguet-Kondracki Novel Adociaquinone Derivatives from the Indonesian Sponge Xestospongia sp. Marine Drugs kinase inhibitor adociaquinone xestoadociaquinone 14-carboxy-xestoquinol sulfate xestoadociaminal Xestospongia sp. |
| title | Novel Adociaquinone Derivatives from the Indonesian Sponge Xestospongia sp. |
| title_full | Novel Adociaquinone Derivatives from the Indonesian Sponge Xestospongia sp. |
| title_fullStr | Novel Adociaquinone Derivatives from the Indonesian Sponge Xestospongia sp. |
| title_full_unstemmed | Novel Adociaquinone Derivatives from the Indonesian Sponge Xestospongia sp. |
| title_short | Novel Adociaquinone Derivatives from the Indonesian Sponge Xestospongia sp. |
| title_sort | novel adociaquinone derivatives from the indonesian sponge xestospongia sp |
| topic | kinase inhibitor adociaquinone xestoadociaquinone 14-carboxy-xestoquinol sulfate xestoadociaminal Xestospongia sp. |
| url | http://www.mdpi.com/1660-3397/13/5/2617 |
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