Trends in renal function in Northern Sweden 1986–2014: data from the seven cross-sectional surveys within the Northern Sweden MONICA study
Objective The prevalence of chronic kidney disease (CKD) is increasing globally, and CKD is closely related to cardiovascular disease (CVD). CKD and CVD share several risk factors (RF), such as diabetes, hypertension, obesity and smoking, and the prevalence of these RF has changed during the last de...
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BMJ Publishing Group
2023-08-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/13/8/e072664.full |
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| author | Stefan Söderberg Tanja Zeller Johan Hultdin Maria Wennberg Julia de Man Lapidoth P Andreas Jonsson Maria Eriksson Svensson |
| author_facet | Stefan Söderberg Tanja Zeller Johan Hultdin Maria Wennberg Julia de Man Lapidoth P Andreas Jonsson Maria Eriksson Svensson |
| author_sort | Stefan Söderberg |
| collection | DOAJ |
| description | Objective The prevalence of chronic kidney disease (CKD) is increasing globally, and CKD is closely related to cardiovascular disease (CVD). CKD and CVD share several risk factors (RF), such as diabetes, hypertension, obesity and smoking, and the prevalence of these RF has changed during the last decades, and we aimed to study the effect on renal function over time.Design Repeated cross-sectional population-based studies.Setting The two Northern counties (Norr- and Västerbotten) in Sweden.Participants Within the MONitoring Trends and Determinants of CArdiovascular Disease (MONICA) study, seven surveys were performed between 1986 and 2014, including participants aged 25–64 years (n=10 185).Interventions None.Measures Information on anthropometry, blood pressure and cardiovascular risk factors was collected. Creatinine and cystatin C were analysed in stored blood samples and the estimated glomerular filtration rate (eGFR) calculated using the creatinine-based Lund–Malmö revised and Chronic Kidney Disease Epidemiology Collaboration (eGFRcrea) equations as well as the cystatin C-based Caucasian, Asian, Paediatric and Adult cohort (CAPA) equation (eGFRcysC). Renal function over time was analysed using univariable and multivariable linear regression models.Results Renal function, both eGFRcrea and eGFRcysC, decreased over time (both p<0.001) and differed between counties and sexes. In a multivariable analysis, study year remained inversely associated with both eGFRcrea and eGFRcysC (both p<0.001) after adjustment for classical cardiovascular RF.Conclusion Renal function has deteriorated in Northern Sweden between 1986 and 2014. |
| first_indexed | 2024-03-12T11:22:19Z |
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| id | doaj.art-cc7a62d62d0c42ba9bf2c020cacee270 |
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| issn | 2044-6055 |
| language | English |
| last_indexed | 2024-03-12T11:22:19Z |
| publishDate | 2023-08-01 |
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| spelling | doaj.art-cc7a62d62d0c42ba9bf2c020cacee2702023-09-01T18:10:07ZengBMJ Publishing GroupBMJ Open2044-60552023-08-0113810.1136/bmjopen-2023-072664Trends in renal function in Northern Sweden 1986–2014: data from the seven cross-sectional surveys within the Northern Sweden MONICA studyStefan Söderberg0Tanja Zeller1Johan Hultdin2Maria Wennberg3Julia de Man Lapidoth4P Andreas Jonsson5Maria Eriksson Svensson6Department of Public Health and Clinical Medicine, Umea Universitet, Umea, SwedenDepartment of Cardiology, University Medical Center Hamburg-Eppendorf University Heart & Vascular Center, Hamburg, GermanyMedical Biosciences, Clinical Chemistry, Umeå University, Umeå, SwedenDepartment of Public Health and Clinical Medicine, Family Medicine, Umeå University, Umeå, SwedenDepartment of Public Health and Clinical Medicine, Umeå University, Umeå, SwedenDepartment of Public Health and Clinical Medicine, Umeå University, Umeå, SwedenRenal Medicine, Uppsala University, Uppsala, SwedenObjective The prevalence of chronic kidney disease (CKD) is increasing globally, and CKD is closely related to cardiovascular disease (CVD). CKD and CVD share several risk factors (RF), such as diabetes, hypertension, obesity and smoking, and the prevalence of these RF has changed during the last decades, and we aimed to study the effect on renal function over time.Design Repeated cross-sectional population-based studies.Setting The two Northern counties (Norr- and Västerbotten) in Sweden.Participants Within the MONitoring Trends and Determinants of CArdiovascular Disease (MONICA) study, seven surveys were performed between 1986 and 2014, including participants aged 25–64 years (n=10 185).Interventions None.Measures Information on anthropometry, blood pressure and cardiovascular risk factors was collected. Creatinine and cystatin C were analysed in stored blood samples and the estimated glomerular filtration rate (eGFR) calculated using the creatinine-based Lund–Malmö revised and Chronic Kidney Disease Epidemiology Collaboration (eGFRcrea) equations as well as the cystatin C-based Caucasian, Asian, Paediatric and Adult cohort (CAPA) equation (eGFRcysC). Renal function over time was analysed using univariable and multivariable linear regression models.Results Renal function, both eGFRcrea and eGFRcysC, decreased over time (both p<0.001) and differed between counties and sexes. In a multivariable analysis, study year remained inversely associated with both eGFRcrea and eGFRcysC (both p<0.001) after adjustment for classical cardiovascular RF.Conclusion Renal function has deteriorated in Northern Sweden between 1986 and 2014.https://bmjopen.bmj.com/content/13/8/e072664.full |
| spellingShingle | Stefan Söderberg Tanja Zeller Johan Hultdin Maria Wennberg Julia de Man Lapidoth P Andreas Jonsson Maria Eriksson Svensson Trends in renal function in Northern Sweden 1986–2014: data from the seven cross-sectional surveys within the Northern Sweden MONICA study BMJ Open |
| title | Trends in renal function in Northern Sweden 1986–2014: data from the seven cross-sectional surveys within the Northern Sweden MONICA study |
| title_full | Trends in renal function in Northern Sweden 1986–2014: data from the seven cross-sectional surveys within the Northern Sweden MONICA study |
| title_fullStr | Trends in renal function in Northern Sweden 1986–2014: data from the seven cross-sectional surveys within the Northern Sweden MONICA study |
| title_full_unstemmed | Trends in renal function in Northern Sweden 1986–2014: data from the seven cross-sectional surveys within the Northern Sweden MONICA study |
| title_short | Trends in renal function in Northern Sweden 1986–2014: data from the seven cross-sectional surveys within the Northern Sweden MONICA study |
| title_sort | trends in renal function in northern sweden 1986 2014 data from the seven cross sectional surveys within the northern sweden monica study |
| url | https://bmjopen.bmj.com/content/13/8/e072664.full |
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