The Protective Effect of Kolaviron on Molecular, Cellular, and Behavioral Characterization of Cerebellum in the Rat Model of Demyelinating Diseases

The Protective Effect of Kolaviron on Molecular, Cellular, and Behavioral Characterization of Cerebellum in the Rat Model of Demyelinating Diseases

Introduction: This study aimed at assessing the protective mechanisms of Kolaviron (KV) on the cerebellum in a rat model of demyelination. Methods: Twenty-eight male Wistar rats were used in the present study. They were randomly divided into 4 groups of 7 rats. Group A (control) received corn oil (0...

Full description

Bibliographic Details
Main Authors:	Gabriel Olaiya Omotoso, Leviticus Oghenevurinrin Arietarhire, Ileje Inelo Ukwubile, Ismail Temitayo Gbadamosi
Format:	Article
Language:	English
Published:	Iran University of Medical Sciences 2020-09-01
Series:	Basic and Clinical Neuroscience
Subjects:	demyelinating disease cerebellum cuprizone kolaviron oxidative stress
Online Access:	http://bcn.iums.ac.ir/article-1-1151-en.html

Similar Items

Kolaviron neuroprotective effect against okadaic acid-provoked cognitive impairment
by: Morteza Nazari-Serenjeh, et al.
Published: (2024-02-01)

Protective role of glycine and kolaviron on lipopolysaccharide-induced alterations of raw U937 cells and U937-derived macrophages
by: Tebekeme OKOKO, et al.
Published: (2022-02-01)

The role of Kolaviron, a bioflavonoid from Garcinia kola, in the management of cardiovascular diseases: A systematic review
by: Francis J. Olatoye, et al.
Published: (2024-03-01)

Kolaviron alleviates haematological abnormalities and hepato-renal damage in Naja nigricollis nigricollis venom-treated rats
by: Azubuike Ikechukwu Okafor, et al.
Published: (2022-01-01)

Inflammatory demyelination alters subcortical visual circuits
by: Sheila Espírito Santo Araújo, et al.
Published: (2017-08-01)

Deciphering the Genetic Crosstalk between Microglia and Oligodendrocyte Precursor Cells during Demyelination and Remyelination Using Transcriptomic Data
by: Jennifer Enrich-Bengoa, et al.
Published: (2022-11-01)

Ferulic Acid Ameliorates Cell Injuries, Cognitive and Motor Impairments in Cuprizone-Induced Demyelination Model of Multiple Sclerosis
by: Mojtaba Ghobadi, et al.
Published: (2022-11-01)

Delayed Demyelination and Impaired Remyelination in Aged Mice in the Cuprizone Model
by: Stefan Gingele, et al.
Published: (2020-04-01)

Age Influences Microglial Activation After Cuprizone-Induced Demyelination
by: Barbara Klein, et al.
Published: (2018-09-01)

Protective effects of erythropoietin against cuprizone-induced oxidative stress and demyelination in the mouse corpus callosum
by: Iraj Ragerdi Kashani, et al.
Published: (2017-08-01)

Voluntary running wheel attenuates motor deterioration and brain damage in cuprizone-induced demyelination
by: Georgia Mandolesi, et al.
Published: (2019-09-01)

Evaluation of neuroprotective effects of alpha-tocopherol in cuprizone-induced demyelination model of multiple sclerosis
by: Nilesh Kumar Mitra, et al.
Published: (2020-01-01)

Vanillic Acid Ameliorates Demyelination in a Cuprizone-Induced Multiple Sclerosis Rat Model: Possible Underlying Mechanisms
by: Sally M. Safwat, et al.
Published: (2023-12-01)

Microglia/macrophage polarization regulates spontaneous remyelination in intermittent cuprizone model of demyelination
by: Davood Zarini, et al.
Published: (2024-03-01)

GRAY AND WHITE MATTER DEMYELINATION AND REMYELINATION DETECTED WITH MULTIMODAL QUANTITATIVE MRI ANALYSIS AT 11.7T IN A CHRONIC MOUSE MODEL OF MULTIPLE SCLEROSIS
by: Alexandra Petiet, et al.
Published: (2016-10-01)

Genetic detection of Sonic hedgehog (Shh) expression and cellular response in the progression of acute through chronic demyelination and remyelination
by: Maria A. Sanchez, et al.
Published: (2018-07-01)

Oligodendrocyte death and myelin loss in the cuprizone model: an updated overview of the intrinsic and extrinsic causes of cuprizone demyelination
by: Martin Zirngibl, et al.
Published: (2022-05-01)

17β-estradiol protects male mice from cuprizone-induced demyelination and oligodendrocyte loss
by: Lorelei C. Taylor, et al.
Published: (2010-08-01)

Sex Differences in the Behavioural Aspects of the Cuprizone-Induced Demyelination Model in Mice
by: Kelly F. Paton, et al.
Published: (2022-12-01)

Venlafaxine Improves the Cognitive Impairment and Depression-Like Behaviors in a Cuprizone Mouse Model by Alleviating Demyelination and Neuroinflammation in the Brain
by: Yanbo Zhang, et al.
Published: (2019-04-01)

Abcd1 deficiency accelerates cuprizone-induced oligodendrocyte loss and axonopathy in a demyelinating mouse model of X-linked adrenoleukodystrophy
by: Ksenija Martinović, et al.
Published: (2023-06-01)

Protective and therapeutic role of 2-carba-cyclic phosphatidic acid in demyelinating disease
by: Shinji Yamamoto, et al.
Published: (2017-07-01)

Localized Increased Permeability of Blood–Brain Barrier for Antibody Conjugates in the Cuprizone Model of Demyelination
by: Tatiana Abakumova, et al.
Published: (2023-08-01)

Disinhibition of Cathepsin C Caused by Cystatin F Deficiency Aggravates the Demyelination in a Cuprizone Model
by: Junjie Liang, et al.
Published: (2016-12-01)

Temporal Changes in In Vivo Glutamate Signal during Demyelination and Remyelination in the Corpus Callosum: A Glutamate-Weighted Chemical Exchange Saturation Transfer Imaging Study
by: Do-Wan Lee, et al.
Published: (2020-12-01)

Single-cell microglial transcriptomics during demyelination defines a microglial state required for lytic carcass clearance
by: Sameera Zia, et al.
Published: (2022-12-01)

Laquinimod ameliorates secondary brain inflammation
by: Julia Nedelcu, et al.
Published: (2020-02-01)

Mechanisms of remyelination: recent insight from experimental models
by: Tanaka Tatsuhide, et al.
Published: (2014-08-01)

Effects of Bone Marrow Mesenchymal Stem Cells on Myelin Repair and Emotional Changes of a Cuprizone-Induced Demyelination Model
by: Chu Lei, et al.
Published: (2023-02-01)

rHIgM22 enhances remyelination in the brain of the cuprizone mouse model of demyelination
by: Ariana P. Mullin, et al.
Published: (2017-09-01)

Acquired demyelination but not genetic developmental defects in myelination leads to brain tissue stiffness changes
by: Dominic Eberle, et al.
Published: (2020-11-01)

Human Glial Progenitor Cells Effectively Remyelinate the Demyelinated Adult Brain
by: Martha S. Windrem, et al.
Published: (2020-05-01)

Korean Red Ginseng extract ameliorates demyelination by inhibiting infiltration and activation of immune cells in cuprizone-administrated mice
by: Min Jung Lee, et al.
Published: (2023-09-01)

Brain region dependent molecular signatures and myelin repair following chronic demyelination
by: Grace Samtani, et al.
Published: (2023-04-01)

Aquaporin-4 Expression during Toxic and Autoimmune Demyelination
by: Sven Olaf Rohr, et al.
Published: (2020-09-01)

Longitudinal evaluation of demyelinated lesions in a multiple sclerosis model using ultrashort echo time magnetization transfer (UTE-MT) imaging
by: Caroline Guglielmetti, et al.
Published: (2020-03-01)

The Cuprizone Mouse Model: A Comparative Study of Cuprizone Formulations from Different Manufacturers
by: Malena Beecken, et al.
Published: (2023-06-01)

Inhibiting microglia exacerbates the early effects of cuprizone in males in a rat model of multiple sclerosis, with no effect in females
by: Soniya Xavier, et al.
Published: (2023-09-01)

Intravenous transplantation of mouse embryonic stem cells attenuates demyelination in an ICR outbred mouse model of demyelinating diseases
by: Kidsadagon Pringproa, et al.
Published: (2016-01-01)

Novel cell-based analysis reveals region-dependent changes in microglial dynamics in grey matter in a cuprizone model of demyelination
by: Ilias Roufagalas, et al.
Published: (2021-09-01)