Circulating miRNA as a Biomarker in Oral Cancer Liquid Biopsy
Oral cancer is currently challenging the healthcare system, with a high incidence among the population and a poor survival rate. One of the main focuses related to this malignancy is the urge to implement a viable approach for improving its early diagnosis. By introducing the use of liquid biopsy an...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/11/3/965 |
| _version_ | 1827751128404590592 |
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| author | Alexandra Roi Simina Boia Laura-Cristina Rusu Ciprian Ioan Roi Eugen Radu Boia Mircea Riviș |
| author_facet | Alexandra Roi Simina Boia Laura-Cristina Rusu Ciprian Ioan Roi Eugen Radu Boia Mircea Riviș |
| author_sort | Alexandra Roi |
| collection | DOAJ |
| description | Oral cancer is currently challenging the healthcare system, with a high incidence among the population and a poor survival rate. One of the main focuses related to this malignancy is the urge to implement a viable approach for improving its early diagnosis. By introducing the use of liquid biopsy and the identification of potential biomarkers, aiming for a noninvasive approach, new advancements offer promising perspectives in the diagnosis of oral cancer. The present review discusses the potential of circulating miRNAs as oral cancer biomarkers identified in body fluids such as serum, plasma, and saliva samples of oral cancer patients. Existing results reveal an important implication of different miRNA expressions involved in the initiation, development, progression, and metastasis rate of oral malignancy. Liquid biomarkers can play a crucial role in the development of the concept of personalized medicine, providing a wide range of clinical applications and future targeted therapies. |
| first_indexed | 2024-03-11T06:53:55Z |
| format | Article |
| id | doaj.art-cc7b5b817a9842069db79eed728f7170 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T06:53:55Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-cc7b5b817a9842069db79eed728f71702023-11-17T09:48:11ZengMDPI AGBiomedicines2227-90592023-03-0111396510.3390/biomedicines11030965Circulating miRNA as a Biomarker in Oral Cancer Liquid BiopsyAlexandra Roi0Simina Boia1Laura-Cristina Rusu2Ciprian Ioan Roi3Eugen Radu Boia4Mircea Riviș5Department of Oral Pathology, Multidisciplinary Center for Research, Evaluation, Diagnosis and Therapies in Oral Medicine, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, RomaniaDepartment of Periodontology, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, RomaniaDepartment of Oral Pathology, Multidisciplinary Center for Research, Evaluation, Diagnosis and Therapies in Oral Medicine, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, RomaniaDepartment of Anesthesiology and Oral Surgery, Multidisciplinary Center for Research, Evaluation, Diagnosis and Therapies in Oral Medicine, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 30041 Timisoara, RomaniaDepartment of Ear, Nose and Throat, “Victor Babes” University of Medicine and Pharmacy Timisoara, 2 Eftimie Murgu Sq., 300041 Timisoara, RomaniaDepartment of Anesthesiology and Oral Surgery, Multidisciplinary Center for Research, Evaluation, Diagnosis and Therapies in Oral Medicine, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 30041 Timisoara, RomaniaOral cancer is currently challenging the healthcare system, with a high incidence among the population and a poor survival rate. One of the main focuses related to this malignancy is the urge to implement a viable approach for improving its early diagnosis. By introducing the use of liquid biopsy and the identification of potential biomarkers, aiming for a noninvasive approach, new advancements offer promising perspectives in the diagnosis of oral cancer. The present review discusses the potential of circulating miRNAs as oral cancer biomarkers identified in body fluids such as serum, plasma, and saliva samples of oral cancer patients. Existing results reveal an important implication of different miRNA expressions involved in the initiation, development, progression, and metastasis rate of oral malignancy. Liquid biomarkers can play a crucial role in the development of the concept of personalized medicine, providing a wide range of clinical applications and future targeted therapies.https://www.mdpi.com/2227-9059/11/3/965liquid biopsyoral cancermiRNAearly diagnosisnoninvasivesaliva |
| spellingShingle | Alexandra Roi Simina Boia Laura-Cristina Rusu Ciprian Ioan Roi Eugen Radu Boia Mircea Riviș Circulating miRNA as a Biomarker in Oral Cancer Liquid Biopsy Biomedicines liquid biopsy oral cancer miRNA early diagnosis noninvasive saliva |
| title | Circulating miRNA as a Biomarker in Oral Cancer Liquid Biopsy |
| title_full | Circulating miRNA as a Biomarker in Oral Cancer Liquid Biopsy |
| title_fullStr | Circulating miRNA as a Biomarker in Oral Cancer Liquid Biopsy |
| title_full_unstemmed | Circulating miRNA as a Biomarker in Oral Cancer Liquid Biopsy |
| title_short | Circulating miRNA as a Biomarker in Oral Cancer Liquid Biopsy |
| title_sort | circulating mirna as a biomarker in oral cancer liquid biopsy |
| topic | liquid biopsy oral cancer miRNA early diagnosis noninvasive saliva |
| url | https://www.mdpi.com/2227-9059/11/3/965 |
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