AKR1C1 promotes non-small cell lung cancer proliferation via crosstalk between HIF-1α and metabolic reprogramming

AKR1C1 promotes non-small cell lung cancer proliferation via crosstalk between HIF-1α and metabolic reprogramming

Non-small cell lung cancer (NSCLC) ranks first among cancer death worldwide. Despite efficacy and safety priority, targeted therapy only benefits ∼30% patients, leading to the unchanged survival rates for whole NSCLC patients. Metabolic reprogramming occurs to offer energy and intermediates for fuel...

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Bibliographic Details
Main Authors: Lin-Lin Chang, Pei-Hua Lu, Wei Yang, Yan Hu, Lin Zheng, Qiong Zhao, Neng-Ming Lin, Wen-Zhou Zhang
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Translational Oncology
Subjects:
HIF-1α
AKR1C1
Metabolic reprogramming
Proliferation
Online Access:http://www.sciencedirect.com/science/article/pii/S193652332200081X

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