Organizing pneumonia secondary to pulmonary cryptococcosis in immunocompromised patient
Pulmonary cryptococcal infections are fungal infections that often occur in immunocompromised patients and present with a variety of radiographic patterns ranging from nodular to infiltrative shadows. In the present case, we experienced a rare case of organizing pneumonia due to cryptococcal infecti...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Respiratory Medicine Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213007123001703 |
| _version_ | 1797319510737289216 |
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| author | Zentaro Saito Takanori Ito Takuma Imakita Issei Oi Osamu Kanai Kohei Fujita |
| author_facet | Zentaro Saito Takanori Ito Takuma Imakita Issei Oi Osamu Kanai Kohei Fujita |
| author_sort | Zentaro Saito |
| collection | DOAJ |
| description | Pulmonary cryptococcal infections are fungal infections that often occur in immunocompromised patients and present with a variety of radiographic patterns ranging from nodular to infiltrative shadows. In the present case, we experienced a rare case of organizing pneumonia due to cryptococcal infection in a 71-year-old woman with rheumatoid arthritis. Transbronchial lung biopsy showing fibrotic changes in the alveolar walls, small granulation lesions and cryptococcal organisms with positive Grocott staining. Serum cryptococcal antigen was also found to be positive. Based on these findings, we confirmed the diagnosis of secondary organizing pneumonia due to cryptococcal infection. Treatment with corticosteroids and antifungal drugs led to improvement of the cough and reduction of organizing pneumonia. In immunocompetent patients with organizing pneumonia, it is essential to perform bronchoscopic lung biopsies and serum antigen tests to search for the cause, whenever possible, as it may be due to an infection caused by Cryptococcus, as in the present case. |
| first_indexed | 2024-03-08T04:07:56Z |
| format | Article |
| id | doaj.art-cc8036cbf2ff4147a72dba23801a30c5 |
| institution | Directory Open Access Journal |
| issn | 2213-0071 |
| language | English |
| last_indexed | 2024-03-08T04:07:56Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Respiratory Medicine Case Reports |
| spelling | doaj.art-cc8036cbf2ff4147a72dba23801a30c52024-02-09T04:48:13ZengElsevierRespiratory Medicine Case Reports2213-00712024-01-0147101975Organizing pneumonia secondary to pulmonary cryptococcosis in immunocompromised patientZentaro Saito0Takanori Ito1Takuma Imakita2Issei Oi3Osamu Kanai4Kohei Fujita5Division of Respiratory Medicine, Center for Respiratory Diseases, National Hospital Organization Kyoto Medical Center, Kyoto, JapanDivision of Respiratory Medicine, Center for Respiratory Diseases, National Hospital Organization Kyoto Medical Center, Kyoto, JapanDivision of Respiratory Medicine, Center for Respiratory Diseases, National Hospital Organization Kyoto Medical Center, Kyoto, JapanDivision of Respiratory Medicine, Center for Respiratory Diseases, National Hospital Organization Kyoto Medical Center, Kyoto, JapanDivision of Respiratory Medicine, Center for Respiratory Diseases, National Hospital Organization Kyoto Medical Center, Kyoto, Japan; Department of Infectious Diseases, National Hospital Organization Kyoto Medical Center, Kyoto, JapanDivision of Respiratory Medicine, Center for Respiratory Diseases, National Hospital Organization Kyoto Medical Center, Kyoto, Japan; Department of Infectious Diseases, National Hospital Organization Kyoto Medical Center, Kyoto, Japan; Corresponding author. Division of Respiratory Medicine, Center for Respiratory Diseases, National Hospital Organization Kyoto Medical Center, 612-8555 1-1, Fukakusa-Mukaihata-Cho, Fushimi-Ku, Kyoto, Japan.Pulmonary cryptococcal infections are fungal infections that often occur in immunocompromised patients and present with a variety of radiographic patterns ranging from nodular to infiltrative shadows. In the present case, we experienced a rare case of organizing pneumonia due to cryptococcal infection in a 71-year-old woman with rheumatoid arthritis. Transbronchial lung biopsy showing fibrotic changes in the alveolar walls, small granulation lesions and cryptococcal organisms with positive Grocott staining. Serum cryptococcal antigen was also found to be positive. Based on these findings, we confirmed the diagnosis of secondary organizing pneumonia due to cryptococcal infection. Treatment with corticosteroids and antifungal drugs led to improvement of the cough and reduction of organizing pneumonia. In immunocompetent patients with organizing pneumonia, it is essential to perform bronchoscopic lung biopsies and serum antigen tests to search for the cause, whenever possible, as it may be due to an infection caused by Cryptococcus, as in the present case.http://www.sciencedirect.com/science/article/pii/S2213007123001703CryptococcosisCryptococcus neoformansOrganizing pneumoniaImmunocompromised hostDiabetes mellitusFungal disease |
| spellingShingle | Zentaro Saito Takanori Ito Takuma Imakita Issei Oi Osamu Kanai Kohei Fujita Organizing pneumonia secondary to pulmonary cryptococcosis in immunocompromised patient Respiratory Medicine Case Reports Cryptococcosis Cryptococcus neoformans Organizing pneumonia Immunocompromised host Diabetes mellitus Fungal disease |
| title | Organizing pneumonia secondary to pulmonary cryptococcosis in immunocompromised patient |
| title_full | Organizing pneumonia secondary to pulmonary cryptococcosis in immunocompromised patient |
| title_fullStr | Organizing pneumonia secondary to pulmonary cryptococcosis in immunocompromised patient |
| title_full_unstemmed | Organizing pneumonia secondary to pulmonary cryptococcosis in immunocompromised patient |
| title_short | Organizing pneumonia secondary to pulmonary cryptococcosis in immunocompromised patient |
| title_sort | organizing pneumonia secondary to pulmonary cryptococcosis in immunocompromised patient |
| topic | Cryptococcosis Cryptococcus neoformans Organizing pneumonia Immunocompromised host Diabetes mellitus Fungal disease |
| url | http://www.sciencedirect.com/science/article/pii/S2213007123001703 |
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