GSH-Activatable Metal-Phenolic Networks for Photothermal-Enhanced Chemotherapy and Chemodynamic Therapy
Chemotherapy (CT) plays an important role in the antitumor process, but the unsatisfactory therapeutic efficacy and the obvious toxic side effects of CT seriously restrict its application. To overcome the limitations of CT, the strategy of chemotherapy enhanced by chemodynamic therapy (CDT) and phot...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/14/9/436 |
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| author | Weijun Chen Meiyang Yang Jie Li Zhilan Chen Lefei Hu Jiannan Zhang Liangyu Cai Lipeng Qiu Jinghua Chen |
| author_facet | Weijun Chen Meiyang Yang Jie Li Zhilan Chen Lefei Hu Jiannan Zhang Liangyu Cai Lipeng Qiu Jinghua Chen |
| author_sort | Weijun Chen |
| collection | DOAJ |
| description | Chemotherapy (CT) plays an important role in the antitumor process, but the unsatisfactory therapeutic efficacy and the obvious toxic side effects of CT seriously restrict its application. To overcome the limitations of CT, the strategy of chemotherapy enhanced by chemodynamic therapy (CDT) and photothermal therapy (PTT) has been considered a promising approach to improve the anticancer effect. Herein, a novel GSH-activatable Cu<sup>2+</sup>-Quercetin network (QC) was synthesized via a convenient strategy to load Au nanoparticles (NPs) and DOX, named QCDA, for the synergistic therapy of CT/CDT/PTT. The results showed that QCDA exhibited GSH-sensitive degradation and “cargos” release in cancer cells, and then PTT and CDT caused by Au NPs and Cu<sup>+</sup> significantly enhanced the CT effect of DOX and Quercetin on anticancer. More importantly, the PTT and depleted GSH accelerated the Fenton-like ionization process resulting in facilitating the CDT efficiency. Collectively, the multi-mode synergistic strategy of CT/CDT/PTT, which showed an excellent therapeutic effect, maybe a potential therapeutic pathway for anticancer. |
| first_indexed | 2024-03-10T22:36:34Z |
| format | Article |
| id | doaj.art-cc8091b128944c2498b36ae8ab317abe |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-03-10T22:36:34Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-cc8091b128944c2498b36ae8ab317abe2023-11-19T11:23:04ZengMDPI AGJournal of Functional Biomaterials2079-49832023-08-0114943610.3390/jfb14090436GSH-Activatable Metal-Phenolic Networks for Photothermal-Enhanced Chemotherapy and Chemodynamic TherapyWeijun Chen0Meiyang Yang1Jie Li2Zhilan Chen3Lefei Hu4Jiannan Zhang5Liangyu Cai6Lipeng Qiu7Jinghua Chen8School of Life Sciences and Health Engineering, Jiangnan University, Wuxi 214122, ChinaSchool of Life Sciences and Health Engineering, Jiangnan University, Wuxi 214122, ChinaSchool of Life Sciences and Health Engineering, Jiangnan University, Wuxi 214122, ChinaSchool of Life Sciences and Health Engineering, Jiangnan University, Wuxi 214122, ChinaDepartment of Biological Science, National University of Singapore, Singapore 119077, SingaporeDepartment of Anesthesiology, Wuxi Traditional Chinese Medicine Hospital, Wuxi 214071, ChinaDepartment of Anesthesiology, Wuxi Traditional Chinese Medicine Hospital, Wuxi 214071, ChinaSchool of Life Sciences and Health Engineering, Jiangnan University, Wuxi 214122, ChinaSchool of Life Sciences and Health Engineering, Jiangnan University, Wuxi 214122, ChinaChemotherapy (CT) plays an important role in the antitumor process, but the unsatisfactory therapeutic efficacy and the obvious toxic side effects of CT seriously restrict its application. To overcome the limitations of CT, the strategy of chemotherapy enhanced by chemodynamic therapy (CDT) and photothermal therapy (PTT) has been considered a promising approach to improve the anticancer effect. Herein, a novel GSH-activatable Cu<sup>2+</sup>-Quercetin network (QC) was synthesized via a convenient strategy to load Au nanoparticles (NPs) and DOX, named QCDA, for the synergistic therapy of CT/CDT/PTT. The results showed that QCDA exhibited GSH-sensitive degradation and “cargos” release in cancer cells, and then PTT and CDT caused by Au NPs and Cu<sup>+</sup> significantly enhanced the CT effect of DOX and Quercetin on anticancer. More importantly, the PTT and depleted GSH accelerated the Fenton-like ionization process resulting in facilitating the CDT efficiency. Collectively, the multi-mode synergistic strategy of CT/CDT/PTT, which showed an excellent therapeutic effect, maybe a potential therapeutic pathway for anticancer.https://www.mdpi.com/2079-4983/14/9/436metal-phenolic networksGSH-activatablephotothermal therapychemodynamic therapychemotherapy |
| spellingShingle | Weijun Chen Meiyang Yang Jie Li Zhilan Chen Lefei Hu Jiannan Zhang Liangyu Cai Lipeng Qiu Jinghua Chen GSH-Activatable Metal-Phenolic Networks for Photothermal-Enhanced Chemotherapy and Chemodynamic Therapy Journal of Functional Biomaterials metal-phenolic networks GSH-activatable photothermal therapy chemodynamic therapy chemotherapy |
| title | GSH-Activatable Metal-Phenolic Networks for Photothermal-Enhanced Chemotherapy and Chemodynamic Therapy |
| title_full | GSH-Activatable Metal-Phenolic Networks for Photothermal-Enhanced Chemotherapy and Chemodynamic Therapy |
| title_fullStr | GSH-Activatable Metal-Phenolic Networks for Photothermal-Enhanced Chemotherapy and Chemodynamic Therapy |
| title_full_unstemmed | GSH-Activatable Metal-Phenolic Networks for Photothermal-Enhanced Chemotherapy and Chemodynamic Therapy |
| title_short | GSH-Activatable Metal-Phenolic Networks for Photothermal-Enhanced Chemotherapy and Chemodynamic Therapy |
| title_sort | gsh activatable metal phenolic networks for photothermal enhanced chemotherapy and chemodynamic therapy |
| topic | metal-phenolic networks GSH-activatable photothermal therapy chemodynamic therapy chemotherapy |
| url | https://www.mdpi.com/2079-4983/14/9/436 |
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