Shikonin from Chinese herbal medicine induces GSDME-controlled pyroptosis in tumor cells

Shikonin from Chinese herbal medicine induces GSDME-controlled pyroptosis in tumor cells

Objective: To investigate the potential anti-tumor mechanisms of naphthoquinone compound shikonin (SKN) extracted from the root of Chinese herbal medicine plant lithospermum (Lithospermum erythrorhizon Sieb. & Zucc.). Methods: We first observed that SKN treatment led to swelling and bubbles...

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Bibliographic Details
Main Authors: Dongxiao Cui, Sanjiao Wang, Jiajian Guo, Mingrui Yang, Yunqian Li, Yue Zhang, Wenfu Ma
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Journal of Traditional Chinese Medical Sciences
Subjects:
Shikonin
Naphthoquinone compounds
Pyroptosis
Gasdermin
Anti-tumor activity
HeLa cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2095754822000825

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