Biological drug therapy for ocular angiogenesis: Anti‐VEGF agents and novel strategies based on nanotechnology
Abstract Currently, biological drug therapy for ocular angiogenesis treatment is based on the administration of anti‐VEGF agents via intravitreal route. The molecules approved with this purpose for ocular use include pegaptanib, ranibizumab, and aflibercept, whereas bevacizumab is commonly off‐label...
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| Format: | Article |
| Language: | English |
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Wiley
2021-04-01
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| Series: | Pharmacology Research & Perspectives |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/prp2.723 |
| _version_ | 1818441383802830848 |
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| author | María L. Formica Hamoudi G. Awde Alfonso Santiago D. Palma |
| author_facet | María L. Formica Hamoudi G. Awde Alfonso Santiago D. Palma |
| author_sort | María L. Formica |
| collection | DOAJ |
| description | Abstract Currently, biological drug therapy for ocular angiogenesis treatment is based on the administration of anti‐VEGF agents via intravitreal route. The molecules approved with this purpose for ocular use include pegaptanib, ranibizumab, and aflibercept, whereas bevacizumab is commonly off‐label used in the clinical practice. The schedule dosage involves repeated intravitreal injections of anti‐VEGF agents to achieve and maintain effective concentrations in retina and choroids, which are administrated as solutions form. In this review article, we describe the features of different anti‐VEGF agents, major challenges for their ocular delivery and the nanoparticles in development as delivery system of them. In this way, several polymeric and lipid nanoparticles are explored to load anti‐VEGF agents with the aim of achieving sustained drug release and thus, minimize the number of intravitreal injections required. The main challenges were focused in the loading the molecules that maintain their bioactivity after their release from nanoparticulate system, followed the evaluation of them through studies of formulation stability, pharmacokinetic, and efficacy in in vitro and in vivo models. The analysis was based on the information published in peer‐reviewed published papers relevant to anti‐VEGF treatments and nanoparticles developed as ocular anti‐VEGF delivery system. |
| first_indexed | 2024-12-14T18:27:23Z |
| format | Article |
| id | doaj.art-cc83fec712f648bca5d96be651adbfa9 |
| institution | Directory Open Access Journal |
| issn | 2052-1707 |
| language | English |
| last_indexed | 2024-12-14T18:27:23Z |
| publishDate | 2021-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pharmacology Research & Perspectives |
| spelling | doaj.art-cc83fec712f648bca5d96be651adbfa92022-12-21T22:51:53ZengWileyPharmacology Research & Perspectives2052-17072021-04-0192n/an/a10.1002/prp2.723Biological drug therapy for ocular angiogenesis: Anti‐VEGF agents and novel strategies based on nanotechnologyMaría L. Formica0Hamoudi G. Awde Alfonso1Santiago D. Palma2Unidad de Investigación y Desarrollo en Tecnología Farmacéutica (UNITEFA)CONICET and Departamento de FarmaciaFacultad de Ciencias QuímicasUniversidad Nacional de Córdoba Ciudad Universitaria Córdoba5000ArgentinaUnidad de Investigación y Desarrollo en Tecnología Farmacéutica (UNITEFA)CONICET and Departamento de FarmaciaFacultad de Ciencias QuímicasUniversidad Nacional de Córdoba Ciudad Universitaria Córdoba5000ArgentinaUnidad de Investigación y Desarrollo en Tecnología Farmacéutica (UNITEFA)CONICET and Departamento de FarmaciaFacultad de Ciencias QuímicasUniversidad Nacional de Córdoba Ciudad Universitaria Córdoba5000ArgentinaAbstract Currently, biological drug therapy for ocular angiogenesis treatment is based on the administration of anti‐VEGF agents via intravitreal route. The molecules approved with this purpose for ocular use include pegaptanib, ranibizumab, and aflibercept, whereas bevacizumab is commonly off‐label used in the clinical practice. The schedule dosage involves repeated intravitreal injections of anti‐VEGF agents to achieve and maintain effective concentrations in retina and choroids, which are administrated as solutions form. In this review article, we describe the features of different anti‐VEGF agents, major challenges for their ocular delivery and the nanoparticles in development as delivery system of them. In this way, several polymeric and lipid nanoparticles are explored to load anti‐VEGF agents with the aim of achieving sustained drug release and thus, minimize the number of intravitreal injections required. The main challenges were focused in the loading the molecules that maintain their bioactivity after their release from nanoparticulate system, followed the evaluation of them through studies of formulation stability, pharmacokinetic, and efficacy in in vitro and in vivo models. The analysis was based on the information published in peer‐reviewed published papers relevant to anti‐VEGF treatments and nanoparticles developed as ocular anti‐VEGF delivery system.https://doi.org/10.1002/prp2.723anti‐VEGF agentbiological drugsnanoparticlesocular neovascularization |
| spellingShingle | María L. Formica Hamoudi G. Awde Alfonso Santiago D. Palma Biological drug therapy for ocular angiogenesis: Anti‐VEGF agents and novel strategies based on nanotechnology Pharmacology Research & Perspectives anti‐VEGF agent biological drugs nanoparticles ocular neovascularization |
| title | Biological drug therapy for ocular angiogenesis: Anti‐VEGF agents and novel strategies based on nanotechnology |
| title_full | Biological drug therapy for ocular angiogenesis: Anti‐VEGF agents and novel strategies based on nanotechnology |
| title_fullStr | Biological drug therapy for ocular angiogenesis: Anti‐VEGF agents and novel strategies based on nanotechnology |
| title_full_unstemmed | Biological drug therapy for ocular angiogenesis: Anti‐VEGF agents and novel strategies based on nanotechnology |
| title_short | Biological drug therapy for ocular angiogenesis: Anti‐VEGF agents and novel strategies based on nanotechnology |
| title_sort | biological drug therapy for ocular angiogenesis anti vegf agents and novel strategies based on nanotechnology |
| topic | anti‐VEGF agent biological drugs nanoparticles ocular neovascularization |
| url | https://doi.org/10.1002/prp2.723 |
| work_keys_str_mv | AT marialformica biologicaldrugtherapyforocularangiogenesisantivegfagentsandnovelstrategiesbasedonnanotechnology AT hamoudigawdealfonso biologicaldrugtherapyforocularangiogenesisantivegfagentsandnovelstrategiesbasedonnanotechnology AT santiagodpalma biologicaldrugtherapyforocularangiogenesisantivegfagentsandnovelstrategiesbasedonnanotechnology |