Multiple inducible thermogenic mechanisms in the development of cold acclimatization
Extreme cold environment can threaten human health and life through increasing the risk of myocardial infarction, stroke, frostbite, and hypothermia. Insufficient heat production to maintain core body temperature is a major cause of cold injury. To cope with cold stress, human and other mammals have...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2023-05-01
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| Series: | Frigid Zone Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/fzm-2023-0011 |
| _version_ | 1827092905834053632 |
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| author | Lu Huanyu Luo Wenjing |
| author_facet | Lu Huanyu Luo Wenjing |
| author_sort | Lu Huanyu |
| collection | DOAJ |
| description | Extreme cold environment can threaten human health and life through increasing the risk of myocardial infarction, stroke, frostbite, and hypothermia. Insufficient heat production to maintain core body temperature is a major cause of cold injury. To cope with cold stress, human and other mammals have developed the capacity of cold acclimatization to adapt to such a harsh environment. Adaptive non-shivering thermogenesis is a ubiquitous form of cold acclimatization. This review article systematically summarizes the role of three inducible thermogenic forms, including food intake, circadian rhythms, and cold exposure in mediating non-shivering thermogenesis under cold exposure and presents the potential interventions for minimizing the adverse health consequences of cold temperature. |
| first_indexed | 2024-03-13T08:42:25Z |
| format | Article |
| id | doaj.art-cc845b8215c94add9cd1d843ecfe5759 |
| institution | Directory Open Access Journal |
| issn | 2719-8073 |
| language | English |
| last_indexed | 2025-03-20T06:19:37Z |
| publishDate | 2023-05-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Frigid Zone Medicine |
| spelling | doaj.art-cc845b8215c94add9cd1d843ecfe57592024-10-02T15:54:14ZengDe GruyterFrigid Zone Medicine2719-80732023-05-0132839110.2478/fzm-2023-0011Multiple inducible thermogenic mechanisms in the development of cold acclimatizationLu Huanyu0Luo Wenjing1Department of Occupational and Environmental Health, the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, Shaanxi Key Laboratory, School of Public Health, Fourth Military Medical University, Xi’an710000, ChinaDepartment of Occupational and Environmental Health, the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, Shaanxi Key Laboratory, School of Public Health, Fourth Military Medical University, Xi’an710000, ChinaExtreme cold environment can threaten human health and life through increasing the risk of myocardial infarction, stroke, frostbite, and hypothermia. Insufficient heat production to maintain core body temperature is a major cause of cold injury. To cope with cold stress, human and other mammals have developed the capacity of cold acclimatization to adapt to such a harsh environment. Adaptive non-shivering thermogenesis is a ubiquitous form of cold acclimatization. This review article systematically summarizes the role of three inducible thermogenic forms, including food intake, circadian rhythms, and cold exposure in mediating non-shivering thermogenesis under cold exposure and presents the potential interventions for minimizing the adverse health consequences of cold temperature.https://doi.org/10.2478/fzm-2023-0011cold exposureproteomic profilehypothalamuspituitary |
| spellingShingle | Lu Huanyu Luo Wenjing Multiple inducible thermogenic mechanisms in the development of cold acclimatization Frigid Zone Medicine cold exposure proteomic profile hypothalamus pituitary |
| title | Multiple inducible thermogenic mechanisms in the development of cold acclimatization |
| title_full | Multiple inducible thermogenic mechanisms in the development of cold acclimatization |
| title_fullStr | Multiple inducible thermogenic mechanisms in the development of cold acclimatization |
| title_full_unstemmed | Multiple inducible thermogenic mechanisms in the development of cold acclimatization |
| title_short | Multiple inducible thermogenic mechanisms in the development of cold acclimatization |
| title_sort | multiple inducible thermogenic mechanisms in the development of cold acclimatization |
| topic | cold exposure proteomic profile hypothalamus pituitary |
| url | https://doi.org/10.2478/fzm-2023-0011 |
| work_keys_str_mv | AT luhuanyu multipleinduciblethermogenicmechanismsinthedevelopmentofcoldacclimatization AT luowenjing multipleinduciblethermogenicmechanismsinthedevelopmentofcoldacclimatization |