Features of the immune response in children of early age with recurrent respiratory infections
Topicality. Relevance of research is determined by the prevalence of recurrent respiratory infections in children of early age, altering their immune resistance. Aim. With the purpose of immune response of these patients study we examined 107 patients with recurrent respiratory infections and tho...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Zaporozhye State Medical University
2014-10-01
|
| Series: | Zaporožskij Medicinskij Žurnal |
| Subjects: | |
| Online Access: | http://zmj.zsmu.edu.ua/article/view/29119/25903 |
| _version_ | 1818288267763646464 |
|---|---|
| author | L. N. Boyarskaya T. S. Herasimchuk Yu. V. Kotlova A. H. Davydova |
| author_facet | L. N. Boyarskaya T. S. Herasimchuk Yu. V. Kotlova A. H. Davydova |
| author_sort | L. N. Boyarskaya |
| collection | DOAJ |
| description | Topicality. Relevance of research is determined by the prevalence of recurrent respiratory infections in children of early age, altering their immune resistance.
Aim. With the purpose of immune response of these patients study we examined 107 patients with recurrent respiratory infections and those who had episodic respiratory infections.
Methods and results. We studied immunograms of the first level, immunoglobulin G fractions. We have found a decrease of the phagocytic activity of the cells, while increasing of their functional-metabolic state and growing willingness to apoptosis. According to the frequency analysis we identified trends to immunological changes in the form of an imbalance of T-lymphocytes regulatory subpopulations, slow decline of immunoregulatory index and IgG4 subpopulation content in the majority of patients with recurrent respiratory infections.
Conclusion. Changes of the immune response in the early recovery period of the recurrent respiratory infections were characterized with discoordination of units interaction that indicate incomplete bacterial eradication of infection. |
| first_indexed | 2024-12-13T01:53:40Z |
| format | Article |
| id | doaj.art-cc854772594d4bb2b1ba84983737cea1 |
| institution | Directory Open Access Journal |
| issn | 2306-4145 2310-1210 |
| language | English |
| last_indexed | 2024-12-13T01:53:40Z |
| publishDate | 2014-10-01 |
| publisher | Zaporozhye State Medical University |
| record_format | Article |
| series | Zaporožskij Medicinskij Žurnal |
| spelling | doaj.art-cc854772594d4bb2b1ba84983737cea12022-12-22T00:03:27ZengZaporozhye State Medical UniversityZaporožskij Medicinskij Žurnal2306-41452310-12102014-10-0156265http://dx.doi.org/10.14739/2310-1210.2014.5.29119Features of the immune response in children of early age with recurrent respiratory infectionsL. N. Boyarskaya T. S. HerasimchukYu. V. KotlovaA. H. DavydovaTopicality. Relevance of research is determined by the prevalence of recurrent respiratory infections in children of early age, altering their immune resistance. Aim. With the purpose of immune response of these patients study we examined 107 patients with recurrent respiratory infections and those who had episodic respiratory infections. Methods and results. We studied immunograms of the first level, immunoglobulin G fractions. We have found a decrease of the phagocytic activity of the cells, while increasing of their functional-metabolic state and growing willingness to apoptosis. According to the frequency analysis we identified trends to immunological changes in the form of an imbalance of T-lymphocytes regulatory subpopulations, slow decline of immunoregulatory index and IgG4 subpopulation content in the majority of patients with recurrent respiratory infections. Conclusion. Changes of the immune response in the early recovery period of the recurrent respiratory infections were characterized with discoordination of units interaction that indicate incomplete bacterial eradication of infection.http://zmj.zsmu.edu.ua/article/view/29119/25903ChildrenRecurrentRespiratory Infections |
| spellingShingle | L. N. Boyarskaya T. S. Herasimchuk Yu. V. Kotlova A. H. Davydova Features of the immune response in children of early age with recurrent respiratory infections Zaporožskij Medicinskij Žurnal Children Recurrent Respiratory Infections |
| title | Features of the immune response in children of early age with recurrent respiratory infections |
| title_full | Features of the immune response in children of early age with recurrent respiratory infections |
| title_fullStr | Features of the immune response in children of early age with recurrent respiratory infections |
| title_full_unstemmed | Features of the immune response in children of early age with recurrent respiratory infections |
| title_short | Features of the immune response in children of early age with recurrent respiratory infections |
| title_sort | features of the immune response in children of early age with recurrent respiratory infections |
| topic | Children Recurrent Respiratory Infections |
| url | http://zmj.zsmu.edu.ua/article/view/29119/25903 |
| work_keys_str_mv | AT lnboyarskaya featuresoftheimmuneresponseinchildrenofearlyagewithrecurrentrespiratoryinfections AT tsherasimchuk featuresoftheimmuneresponseinchildrenofearlyagewithrecurrentrespiratoryinfections AT yuvkotlova featuresoftheimmuneresponseinchildrenofearlyagewithrecurrentrespiratoryinfections AT ahdavydova featuresoftheimmuneresponseinchildrenofearlyagewithrecurrentrespiratoryinfections |