CD-1a immunoexpression in oral lichen planus and oral lichenoid reaction
Introduction: Oral lichen planus (OLP) is an immunologically mediated mucocutaneous diseases. Langerhans cells (LCs) are antigen presenting cells resident within oral mucosa which, together with intraepithelial lymphocytes, play a role in mucosal defense. The aim of present study was to determine th...
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| Format: | Article |
| Language: | English |
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Babol University of Medical Sciences
2020-09-01
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| Series: | Caspian journal of dental research |
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| Online Access: | http://cjdr.ir/article-1-285-en.html |
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| author | Azadeh Majidian Maryam Seyedmajidi Hamid Abbaszadeh Majid Sharbatdaran Sina Jafari Hemmat Gholinia |
| author_facet | Azadeh Majidian Maryam Seyedmajidi Hamid Abbaszadeh Majid Sharbatdaran Sina Jafari Hemmat Gholinia |
| author_sort | Azadeh Majidian |
| collection | DOAJ |
| description | Introduction: Oral lichen planus (OLP) is an immunologically mediated mucocutaneous diseases. Langerhans cells (LCs) are antigen presenting cells resident within oral mucosa which, together with intraepithelial lymphocytes, play a role in mucosal defense. The aim of present study was to determine the immunohistochemical expression of LC in oral lichenoid reaction (OLR) and OLP compared with normal oral mucosa (NOM).
Materials & Methods: In this cross-sectional study, 61 oral mucosal specimens diagnosed histopathologically as OLP (n=31) and OLR (n=30) and 11 NOM were used to study the immunohistochemical expression of CD1a. The CD1a positive LCs in three regions (basal, suprabasal, and connective tissue) were counted in six randomly selected fields. Data were analyzed using the SPSS 24, T-test, ANOVA, LSD, Games-Howell tests. P<.05 was considered significant.
Results: CD1a expression in OLP and OLR was significantly higher compared to NOM (P<0.001). CD1a expression in OLP was also significantly higher than OLR (P=0.009). There was a statistically significant difference between the three groups in basal, suprabasal and connective tissue regions (P<0.001). The mean of CD1a positive cells in the basal, suprabasal and connective tissue regions was significantly higher in the OLP group than OLR and NOM. Also, in comparison between OLR and NOM, the OLR group had significantly more CD1a positive cells (P<0.05).
Conclusion: Increasing the number of CD1a in OLP and OLR compared with the NOM indicates the role of LC in the pathogenesis of these diseases. |
| first_indexed | 2024-12-22T15:33:00Z |
| format | Article |
| id | doaj.art-cc86269da2ed4128a4c8a2799c6393fe |
| institution | Directory Open Access Journal |
| issn | 2251-9890 2322-2395 |
| language | English |
| last_indexed | 2024-12-22T15:33:00Z |
| publishDate | 2020-09-01 |
| publisher | Babol University of Medical Sciences |
| record_format | Article |
| series | Caspian journal of dental research |
| spelling | doaj.art-cc86269da2ed4128a4c8a2799c6393fe2022-12-21T18:21:19ZengBabol University of Medical SciencesCaspian journal of dental research2251-98902322-23952020-09-01922634CD-1a immunoexpression in oral lichen planus and oral lichenoid reactionAzadeh Majidian0Maryam Seyedmajidi1Hamid Abbaszadeh2Majid Sharbatdaran3Sina Jafari4Hemmat Gholinia5 ,Student Research Committee, Babol University of Medical Sciences, Babol, IR Iran. ,Dental Materials Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IR Iran. ,Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Birjand University of Medical Sciences, Birjand, IR Iran . ,Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IR Iran . ,Department of Prosthodontics, Faculty of Dentistry, Shahed University Tehran,Tehran,IR Iran. ,Health Research Institute, Babol University of Medical Sciences, Babol, IR Iran. Introduction: Oral lichen planus (OLP) is an immunologically mediated mucocutaneous diseases. Langerhans cells (LCs) are antigen presenting cells resident within oral mucosa which, together with intraepithelial lymphocytes, play a role in mucosal defense. The aim of present study was to determine the immunohistochemical expression of LC in oral lichenoid reaction (OLR) and OLP compared with normal oral mucosa (NOM). Materials & Methods: In this cross-sectional study, 61 oral mucosal specimens diagnosed histopathologically as OLP (n=31) and OLR (n=30) and 11 NOM were used to study the immunohistochemical expression of CD1a. The CD1a positive LCs in three regions (basal, suprabasal, and connective tissue) were counted in six randomly selected fields. Data were analyzed using the SPSS 24, T-test, ANOVA, LSD, Games-Howell tests. P<.05 was considered significant. Results: CD1a expression in OLP and OLR was significantly higher compared to NOM (P<0.001). CD1a expression in OLP was also significantly higher than OLR (P=0.009). There was a statistically significant difference between the three groups in basal, suprabasal and connective tissue regions (P<0.001). The mean of CD1a positive cells in the basal, suprabasal and connective tissue regions was significantly higher in the OLP group than OLR and NOM. Also, in comparison between OLR and NOM, the OLR group had significantly more CD1a positive cells (P<0.05). Conclusion: Increasing the number of CD1a in OLP and OLR compared with the NOM indicates the role of LC in the pathogenesis of these diseases.http://cjdr.ir/article-1-285-en.htmllichen planuslichenoid eruptionlangerhans cellsimmunohistochemistry |
| spellingShingle | Azadeh Majidian Maryam Seyedmajidi Hamid Abbaszadeh Majid Sharbatdaran Sina Jafari Hemmat Gholinia CD-1a immunoexpression in oral lichen planus and oral lichenoid reaction Caspian journal of dental research lichen planus lichenoid eruption langerhans cells immunohistochemistry |
| title | CD-1a immunoexpression in oral lichen planus and oral lichenoid reaction |
| title_full | CD-1a immunoexpression in oral lichen planus and oral lichenoid reaction |
| title_fullStr | CD-1a immunoexpression in oral lichen planus and oral lichenoid reaction |
| title_full_unstemmed | CD-1a immunoexpression in oral lichen planus and oral lichenoid reaction |
| title_short | CD-1a immunoexpression in oral lichen planus and oral lichenoid reaction |
| title_sort | cd 1a immunoexpression in oral lichen planus and oral lichenoid reaction |
| topic | lichen planus lichenoid eruption langerhans cells immunohistochemistry |
| url | http://cjdr.ir/article-1-285-en.html |
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