Effects of stress hormones on the brain and cognition: Evidence from normal to pathological aging
Abstract Several studies have demonstrated a wide cognitive variability among aged individuals. One factor thought to be associated with this heterogeneity is exposure to chronic stress throughout life. Animal and human evidence demonstrates that glucocorticoids (GCs), the main class of stress hormo...
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| Format: | Article |
| Language: | English |
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Associação Neurologia Cognitiva e do Comportamento
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| Series: | Dementia & Neuropsychologia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642011000100008&lng=en&tlng=en |
| _version_ | 1819153445719900160 |
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| author | Juliana Nery de Souza-Talarico Marie-France Marin Shireen Sindi Sonia J. Lupien |
| author_facet | Juliana Nery de Souza-Talarico Marie-France Marin Shireen Sindi Sonia J. Lupien |
| author_sort | Juliana Nery de Souza-Talarico |
| collection | DOAJ |
| description | Abstract Several studies have demonstrated a wide cognitive variability among aged individuals. One factor thought to be associated with this heterogeneity is exposure to chronic stress throughout life. Animal and human evidence demonstrates that glucocorticoids (GCs), the main class of stress hormones, are strongly linked to memory performance whereby elevated GC levels are associated with memory performance decline in both normal and pathological cognitive aging. Accordingly, it is believed that GCs may increase the brain's vulnerability to the effects of internal and external insults, and thus may play a role in the development of age-related cognitive disorders such as Alzheimer's disease (AD). The aim of this review article was to investigate the effects of GCs on normal and pathological cognitive aging by showing how these hormones interact with different brain structures involved in cognitive abilities, subsequently worsen memory performance, and increase the risk for developing dementia. |
| first_indexed | 2024-12-22T15:05:18Z |
| format | Article |
| id | doaj.art-cc87444bb6b8474e92e90ffbfd14d1f6 |
| institution | Directory Open Access Journal |
| issn | 1980-5764 |
| language | English |
| last_indexed | 2024-12-22T15:05:18Z |
| publisher | Associação Neurologia Cognitiva e do Comportamento |
| record_format | Article |
| series | Dementia & Neuropsychologia |
| spelling | doaj.art-cc87444bb6b8474e92e90ffbfd14d1f62022-12-21T18:22:00ZengAssociação Neurologia Cognitiva e do ComportamentoDementia & Neuropsychologia1980-57645181610.1590/S1980-57642011DN05010003S1980-57642011000100008Effects of stress hormones on the brain and cognition: Evidence from normal to pathological agingJuliana Nery de Souza-TalaricoMarie-France MarinShireen SindiSonia J. LupienAbstract Several studies have demonstrated a wide cognitive variability among aged individuals. One factor thought to be associated with this heterogeneity is exposure to chronic stress throughout life. Animal and human evidence demonstrates that glucocorticoids (GCs), the main class of stress hormones, are strongly linked to memory performance whereby elevated GC levels are associated with memory performance decline in both normal and pathological cognitive aging. Accordingly, it is believed that GCs may increase the brain's vulnerability to the effects of internal and external insults, and thus may play a role in the development of age-related cognitive disorders such as Alzheimer's disease (AD). The aim of this review article was to investigate the effects of GCs on normal and pathological cognitive aging by showing how these hormones interact with different brain structures involved in cognitive abilities, subsequently worsen memory performance, and increase the risk for developing dementia.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642011000100008&lng=en&tlng=englucocorticoidsmemoryagingAlzheimer's disease |
| spellingShingle | Juliana Nery de Souza-Talarico Marie-France Marin Shireen Sindi Sonia J. Lupien Effects of stress hormones on the brain and cognition: Evidence from normal to pathological aging Dementia & Neuropsychologia glucocorticoids memory aging Alzheimer's disease |
| title | Effects of stress hormones on the brain and cognition: Evidence from normal to pathological aging |
| title_full | Effects of stress hormones on the brain and cognition: Evidence from normal to pathological aging |
| title_fullStr | Effects of stress hormones on the brain and cognition: Evidence from normal to pathological aging |
| title_full_unstemmed | Effects of stress hormones on the brain and cognition: Evidence from normal to pathological aging |
| title_short | Effects of stress hormones on the brain and cognition: Evidence from normal to pathological aging |
| title_sort | effects of stress hormones on the brain and cognition evidence from normal to pathological aging |
| topic | glucocorticoids memory aging Alzheimer's disease |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642011000100008&lng=en&tlng=en |
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