Isoprenoids and Alzheimer's disease: A complex relationship
Cholesterol metabolism has been linked to Alzheimer's disease (AD) neuropathology, which is characterized by amyloid plaques, neurofibrillary tangles and neuroinflammation. Indeed, the use of statins, which inhibit cholesterol and isoprenoid biosynthesis, as potential AD therapeutics is under i...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2006-05-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996105003098 |
| _version_ | 1818616220835905536 |
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| author | S.L. Cole R. Vassar |
| author_facet | S.L. Cole R. Vassar |
| author_sort | S.L. Cole |
| collection | DOAJ |
| description | Cholesterol metabolism has been linked to Alzheimer's disease (AD) neuropathology, which is characterized by amyloid plaques, neurofibrillary tangles and neuroinflammation. Indeed, the use of statins, which inhibit cholesterol and isoprenoid biosynthesis, as potential AD therapeutics is under investigation. Whether statins offer benefit for AD will be determined by the outcome of large, placebo-controlled, randomized clinical trials. However, their use as pharmacological tools has delineated novel roles for isoprenoids in AD. Protein isoprenylation regulates multiple cellular and molecular events and here we review the complex roles of isoprenoids in AD-relevant processes and carefully evaluate isoprenoid pathways as potential AD therapeutic targets. |
| first_indexed | 2024-12-16T16:46:21Z |
| format | Article |
| id | doaj.art-cc87c6a30ec2493e940d6c4a06d7c394 |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-12-16T16:46:21Z |
| publishDate | 2006-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-cc87c6a30ec2493e940d6c4a06d7c3942022-12-21T22:24:11ZengElsevierNeurobiology of Disease1095-953X2006-05-01222209222Isoprenoids and Alzheimer's disease: A complex relationshipS.L. Cole0R. Vassar1Corresponding author. Fax: +1 312 503 7912.; Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, IL 60611, USADepartment of Cell and Molecular Biology, Northwestern University Medical School, Chicago, IL 60611, USACholesterol metabolism has been linked to Alzheimer's disease (AD) neuropathology, which is characterized by amyloid plaques, neurofibrillary tangles and neuroinflammation. Indeed, the use of statins, which inhibit cholesterol and isoprenoid biosynthesis, as potential AD therapeutics is under investigation. Whether statins offer benefit for AD will be determined by the outcome of large, placebo-controlled, randomized clinical trials. However, their use as pharmacological tools has delineated novel roles for isoprenoids in AD. Protein isoprenylation regulates multiple cellular and molecular events and here we review the complex roles of isoprenoids in AD-relevant processes and carefully evaluate isoprenoid pathways as potential AD therapeutic targets.http://www.sciencedirect.com/science/article/pii/S0969996105003098Alzheimer's diseaseStatinsIsoprenoidsCholesterolAPP metabolismAβ |
| spellingShingle | S.L. Cole R. Vassar Isoprenoids and Alzheimer's disease: A complex relationship Neurobiology of Disease Alzheimer's disease Statins Isoprenoids Cholesterol APP metabolism Aβ |
| title | Isoprenoids and Alzheimer's disease: A complex relationship |
| title_full | Isoprenoids and Alzheimer's disease: A complex relationship |
| title_fullStr | Isoprenoids and Alzheimer's disease: A complex relationship |
| title_full_unstemmed | Isoprenoids and Alzheimer's disease: A complex relationship |
| title_short | Isoprenoids and Alzheimer's disease: A complex relationship |
| title_sort | isoprenoids and alzheimer s disease a complex relationship |
| topic | Alzheimer's disease Statins Isoprenoids Cholesterol APP metabolism Aβ |
| url | http://www.sciencedirect.com/science/article/pii/S0969996105003098 |
| work_keys_str_mv | AT slcole isoprenoidsandalzheimersdiseaseacomplexrelationship AT rvassar isoprenoidsandalzheimersdiseaseacomplexrelationship |